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Compound paracetamol and amantadine hydrochloride capsule and preparation method thereof

A technology of compound acetaminophen and capsules, which is applied in capsule delivery, pharmaceutical formulations, amine active ingredients, etc. It can solve the problems of affecting the curative effect of treatment, waste of main ingredients, time-consuming and labor-intensive, etc., and achieves easy swallowing, Fast dispersion and improved stability

Inactive Publication Date: 2016-07-13
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the steps of this method are complicated, time-consuming and labor-intensive, and the cost is high.
But in this method, chlorpheniramine maleate and caffeine are in the form of solution, and then add dextrin aqueous solution, if the solution that can not be sprayed is wasted, the main ingredient in the medicine will be wasted, thereby affecting the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prescription: chlorpheniramine maleate 20g, artificial bezoar 100g, caffeine 150g, amantadine hydrochloride 1000g, acetaminophen 2500g, dextrin 210g.

[0034] Preparation:

[0035] 1. Processing of raw and auxiliary materials:

[0036] 1.1. Mixing: Except for acetaminophen, other raw and auxiliary materials are mixed first. The mixing order is: first mix chlorpheniramine maleate and starch three times in equal increments, and then mix the mixture with artificial bezoar and caffeine Uniform, and then fully mixed with amantadine hydrochloride for 5 minutes.

[0037] 1.2. Pulverization: Pulverize the above mixture, and pulverize it with a 100-mesh sieve on the pulverizer;

[0038] 2. Put the pulverized raw materials and acetaminophen in a wet granulator, set the speed at 110 rpm, dry mix for 5 minutes and stir evenly, take out 10% of the total amount of the drug powder and add it when making pills. The rest are made of soft materials and granulated;

[0039] 3. Prepara...

Embodiment 2

[0047] Prescription: chlorpheniramine maleate 20g, artificial bezoar 100g, caffeine 150g, amantadine hydrochloride 1000g, acetaminophen 2500g, dextrin 210g.

[0048] Preparation:

[0049] 1. Processing of raw and auxiliary materials:

[0050] 1.1. Mixing: Except for acetaminophen, other raw and auxiliary materials are mixed first. The mixing order is: first mix chlorpheniramine maleate and starch three times in equal increments, and then mix the mixture with artificial bezoar and caffeine Uniform, and then fully mixed with amantadine hydrochloride for 5 minutes.

[0051] 1.2. Pulverization: Pulverize the above mixture, and pulverize it with a 100-mesh sieve on the pulverizer;

[0052] 2. Put the pulverized raw materials and acetaminophen in a wet granulator, set the speed at 110 rpm, dry mix for 5 minutes and stir evenly, take out 10% of the total amount of the drug powder and add it when making pills. The rest are made of soft materials and granulated;

[0053] 3. Prepara...

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PUM

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Abstract

The invention discloses a compound paracetamol and amantadine hydrochloride capsule and a preparation method thereof. The compound paracetamol and amantadine hydrochloride capsule comprises chlorphenamine maleate, calculus bovis factitious, caffeine, viregyt hydrochloride, paracetamol and dextrin according to a mass ratio of 1:5:7.5:50:125:4-5. The above compound preparation has the advantages of tidiness, beauty, easy deglutition, fast dispersion in gastric juice, good absorption, high bioavailability and good medicine stability. The preparation method has the advantages of simple operation, easy control, and suitableness for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and specifically provides a compound aminophenol alkane capsule and a preparation method thereof. Background technique [0002] Compound Amantadine Capsules is a compound capsule preparation, and its main ingredients are amantadine hydrochloride, acetaminophen, chlorpheniramine maleate, artificial bezoar and caffeine. It is used for nasal congestion, runny nose, sneezing, sore throat, headache, fever, etc. caused by colds, and can also be used for the prevention and treatment of influenza. [0003] Acetaminophen in the compound acetaminophen preparation can inhibit the synthesis of prostaglandins, and has antipyretic and analgesic effects; amantadine can resist "sub-type A" influenza virus, and can inhibit virus reproduction; caffeine is a central stimulant, It can enhance the antipyretic and analgesic effects of acetaminophen, and can reduce the central inhibitory effects of drowsines...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/48A61P31/16A61P11/00A61P11/02A61P11/04A61P29/00A61K31/4402A61K31/522A61K31/13A61K31/167
Inventor 曾培安张静吴健民
Owner KAMP PHARMA
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