Ephedra extract stripped of ephedrine alkaloids, method for producing same and use of same

An alkaloid and ephedra technology, applied in the field of ephedra alkaloid-removing ephedra extract, can solve problems such as difficulty in ephedra separation, and achieve high pain-inhibiting effect and pain-inhibiting effect

Active Publication Date: 2016-07-06
TOKIWA PHYTOCHEM +2
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is considered that it is difficult to separate the main effect and side effects of ephedra, and there has been no idea of ​​removing ephedra alkaloids from ephedra in order to remove the side effects of ephedra.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ephedra extract stripped of ephedrine alkaloids, method for producing same and use of same
  • Ephedra extract stripped of ephedrine alkaloids, method for producing same and use of same
  • Ephedra extract stripped of ephedrine alkaloids, method for producing same and use of same

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0056] The extraction step of ephedra performed in the production method of the present invention can be performed based on any of the well-known methods. As the extraction solvent, other organic solvents such as water, warm water, hot water, alcoholic solvents, and acetone can be used. Examples of alcohol-based solvents include methanol, ethanol, propanol, isopropanol, butanol, isobutanol, and the like. These solvents may be used alone or in combination.

[0057] The amount of the extraction solvent is preferably 2-100 parts by weight relative to the dry weight of ephedra. The extraction temperature is preferably 4-98°C. The extraction time is preferably 30 minutes to 2 hours. The extraction method can be performed by any method such as stirring extraction, immersion extraction, convection extraction, ultrasonic extraction, supercritical extraction and the like.

[0058] The obtained extract, the filtrate obtained by filtering the extract, the concentrate obtained by conc...

Embodiment 1

[0094] Embodiment 1: the making of ephedra extract.

[0095] The dry raw material of ephedra was pulverized by a mixer, and 500 mL of water was added to 50 g of the pulverized product, and extracted at 95° C. for 1 hour while stirring. Solid-liquid separation was performed, and the extract was centrifuged at 3000 rpm for 10 minutes. The obtained supernatant was concentrated under reduced pressure at 60° C., and then dried under reduced pressure at 60° C. overnight to obtain 9.6 g of ephedra extract.

Embodiment 2

[0096] Example 2: Production of ephedra alkaloid-removing ephedra extract by ion exchange resin SK1B.

[0097] The dry raw material of ephedra was pulverized by a mixer, and 500 mL of water was added to 50 g of the pulverized product, and extracted at 95° C. for 1 hour while stirring. Solid-liquid separation was performed, and the extract was centrifuged at 3000 rpm for 10 minutes, and the obtained supernatant was passed through 25 mL of strong-acid cation exchange resin SK1B (manufactured by Mitsubishi Chemical). Dilute the passage solution with 5% NaHCO 3 Adjusted to pH = 5.2, concentrated under reduced pressure at 60° C., and dried under reduced pressure at 60° C. overnight to obtain 6.3 g of an alkaloid-removing ephedra extract of the genus Ephedra.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Provided is an ephedra extract stripped of ephedrine alkaloids, i.e., an ephedra extract from which ephedrine alkaloids have been removed, and a method for producing an ephedra extract stripped of ephedrine alkaloids. Also provided are an antineoplastic/antimetastatic agent, a pain inhibitor, and an anti-influenza virus drug that include said ephedra extract as an active ingredient.

Description

technical field [0001] The present invention relates to a more safe alkaloid-removing ephedra extract of the genus Ephedra, a method for preparing it, and an anticancer, anti-metastasis drug, pain suppressant drug, and anti-influenza virus drug using it as an active ingredient. Background technique [0002] Ephedra is the aerial stem of Ephedrasinica Stapf, Ephedra intermedia Schrenket C.A. Meyer or Ephedra equisetina Bunge (Ephedraceae) plants of the Ephedra family. Ephedra is the most important crude drug used since ancient times. Examples of traditional Chinese medicines (traditional Chinese medicine prescriptions) containing ephedra as a constituent crude drug include: Aconitum decoction, Wuyao Shunqi decoction, Yuebi decoction, Yuebijiashu decoction, Huishou decoction Powder, Huagai Powder, Gegen Decoction, Gegen Decoction plus Chuanxiong Magnolia, Gegen plus Shufu Decoction, Gegen plus Pinellia Decoction, Gancao Mahuang Decoction, Guijiang Zaocao Huangxinfu Decoction, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61P25/04A61P31/16A61P35/00A61P35/04
CPCA61K36/17A61K2236/00A61P25/04A61P29/00A61P31/16A61P35/00A61P35/04
Inventor 花轮寿彦日向须美子合田幸广日向昌司天仓吉章好村守生山下忠俊
Owner TOKIWA PHYTOCHEM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap