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Preparation method for forming calcium-containing nanosheet film layer on surface of sandblasted and acid-etched titanium

A nano-sheet and sandblasting technology is applied in the field of biomedical materials to achieve the effects of improving osseointegration ability, simple process and low cost

Inactive Publication Date: 2016-06-22
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing technology still has deficiencies in the method of forming micron and nano layer structures and depositing calcium ions, which must be divided into two steps or only forming micron and nano layer structures or depositing calcium ions

Method used

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  • Preparation method for forming calcium-containing nanosheet film layer on surface of sandblasted and acid-etched titanium
  • Preparation method for forming calcium-containing nanosheet film layer on surface of sandblasted and acid-etched titanium
  • Preparation method for forming calcium-containing nanosheet film layer on surface of sandblasted and acid-etched titanium

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Embodiment 1

[0022] A preparation method for forming a calcium-containing nano-sheet film layer on the surface of titanium by sandblasting and acid etching, comprising the following steps:

[0023] Step A) Pretreatment of pure titanium: the use of labels is 600 in sequence # , 800 # , 1200 # , 1500 # The pure titanium sample was polished step by step with fine sandpaper from coarse to fine. Then use double-distilled water, absolute ethanol, and double-distilled water to ultrasonically clean for 5 minutes each, and dry for use.

[0024] Step B) Sand blasting treatment: use 80 mesh Al on the surface of the pure titanium sample in step A) 2 o 3 The sand is blasted at a distance of 1.5cm from the pure titanium surface for 15s under a pressure of 0.4MPa.

[0025] Step C) Acid etching treatment: Treat the pure titanium sample treated in step B) at room temperature in a mixture of nitric acid and hydrofluoric acid for 10 minutes. The mixed acid formula is double distilled water by volume: H...

Embodiment 2

[0028] A preparation method for forming a calcium-containing nano-sheet film layer on the surface of titanium by sandblasting and acid etching, comprising the following steps:

[0029] Step A) Pretreatment of pure titanium: the use of labels is 600 in sequence # , 800 # , 1200 # , 1500 # The pure titanium sample was polished step by step with fine sandpaper from coarse to fine. Then use double-distilled water, absolute ethanol, and double-distilled water to ultrasonically clean for 5 minutes each, and dry for use.

[0030] Step B) Sand blasting treatment: use 80 mesh Al on the surface of the pure titanium sample in step A) 2 o 3 The sand is blasted at a distance of 1.5cm from the pure titanium surface for 15s under a pressure of 0.4MPa.

[0031] Step C) Acid etching treatment: Treat the pure titanium sample treated in step B) at room temperature in a mixture of nitric acid and hydrofluoric acid for 10 minutes. The mixed acid formula is double distilled water by volume: H...

Embodiment 3

[0034] A preparation method for forming a calcium-containing nano-sheet film layer on the surface of titanium by sandblasting and acid etching, comprising the following steps:

[0035]Step A) Pretreatment of pure titanium: the use of labels is 600 in sequence # , 800 # , 1200 # , 1500 # The pure titanium sample was polished step by step with fine sandpaper from coarse to fine. Then use double-distilled water, absolute ethanol, and double-distilled water to ultrasonically clean for 5 minutes each, and dry for use.

[0036] Step B) Sand blasting treatment: use 80 mesh Al on the surface of the pure titanium sample in step A) 2 o 3 The sand is blasted at a distance of 1.5cm from the pure titanium surface for 15s under a pressure of 0.4MPa.

[0037] Step C) Acid etching treatment: Treat the pure titanium sample treated in step B) at room temperature in a mixture of nitric acid and hydrofluoric acid for 10 minutes. The mixed acid formula is double distilled water by volume: HF...

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Abstract

A preparation method for forming a calcium-containing nanosheet film layer on the surface of sandblasted and acid-etched titanium includes the following steps that (A) pure titanium is polished, sandblasted, subjected to ultrasonic cleaning and dried; (B) the pure titanium is acid-etched with hydrofluoric acid / nitric acid mixed liquid, subjected to ultrasonic cleaning with double distilled water and dried, and then acid-etched with concentrated hydrochloric acid / concentrated sulfuric acid mixed acid, subjected to ultrasonic cleaning with double distilled water and dried, so that a micron structure is formed on the surface of the titanium; and (C) the sandblasted and acid-etched pure titanium is subjected to a calcium hydroxide and hydrogen peroxide hydrothermal solution reaction for 0.5-24 hours under a water bath at the temperature of 70-90 DEG C, the calcium-containing nanosheet film layer is formed, and the titanium is processed for 1-3 hours at the temperature of 300-500 DEG C. By means of the surface nanosheet film layer and the calcium element contained in the prepared sample, the compatibility and combining capacity of the prepared sample with bones can be enhanced, adhesion, proliferation and differentiation of osteoblasts on the surface of the titanium are facilitated, and thus the osseointegration capacity of the titanium is improved. Meanwhile, the method is simple in process, processing is easy, and the preparation cost is low.

Description

technical field [0001] The invention belongs to the field of biomedical materials. In particular, it relates to a preparation method for forming a calcium-containing nano-sheet film layer on the surface of titanium by sandblasting and acid etching. Background technique [0002] Titanium has good biocompatibility, and has been widely used in orthopedics and stomatology as implants in bone. The key to forming rapid and stable osseointegration between titanium surface and bone tissue depends on the physical and chemical properties and biological activity of titanium surface. Some scholars believe that the micron-scale topography on the surface of the material is conducive to increasing the specific surface area of ​​the material, can promote the differentiation of osteoblasts and the mineralization of the extracellular matrix on the titanium surface, and can provide a scaffold for cell growth, while the nano-scale topography It can enhance the synthesis of osteoblasts or ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26A61L27/06A61L27/04B82Y40/00
CPCA61L27/047A61L27/06A61L2400/12A61L2400/18B82Y40/00C25D11/26
Inventor 邱憬邵水易明盼盼虞颖娟李明汤春波杨洁陈佳希
Owner AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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