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Medicine composition for treating infant spleen-deficiency type diarrhea and preparing method of medicine composition

A composition and spleen-deficiency technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of heavy burden on the gastrointestinal tract, drug influence, toxic and side effects, etc., to protect the gastrointestinal mucosa, enhance Resistance, non-toxic side effects

Inactive Publication Date: 2016-06-15
李可亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Causes of diarrhea in infants and young children: 1. Physical factors: This disease mainly occurs in infants and young children. heavy burden
(2) Nervous, endocrine, circulatory system, liver and kidney functions are immature in infancy, and the regulation function is poor
(3) The baby's immune function is not perfect
(4) The body fluid distribution of infants is different from that of adults. The proportion of extracellular fluid is relatively high, and the water metabolism is vigorous, and the regulation function is poor, so it is more prone to body fluid and electrolyte disorders
(2) intolerance to carbohydrates
(3) Food allergies
(4) Drug influence
[0008] But above-mentioned therapeutic method affects appetite, treats the symptoms but not the root cause, is unfavorable for treatment, and has toxic side effects

Method used

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Effect test

preparation example Construction

[0073] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:

[0074] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% that is 4 to 8 times that of the mixture, heat to boiling and reflux for 3 to 5 hours, and filter. Use the percolation method to percolate slowly at a rate of 1-2ml per minute, collect the percolation liquid, and then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C. Spray drying, the air inlet temperature of the spray dryer is 160-175°C, the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0075] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obt...

Embodiment 1

[0086] Embodiment 1 Granules

[0087] The preparation process of the granules of the present invention is as follows: get 120g of tiger tail wheel, 200g of musk, 90g of seaweed, 160g of June Snow, 240g of Niu Xixi, 150g of Tuolicao, 250g of Lily, 150g of Curcuma, 300g of Coltsfoot, 160g of Cassia, and 200g of Tongjingcao , 130g half money, 240g frangipani, 150g ganoderma lucidum, 280g magnolia officinalis, 150g puffball, 260g fenxinmu, 180g stretching tendon vine, 320g halberd leaf Wawei, 150g garlic, 130g bougainvillea, 200g yam, Acanthopanax 110g, Shanzhiren 160g, Herba Cistanche 250g, Viola 150g and Geli 230g;

[0088]The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add 90% ethanol with an alcohol concentration 6 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use the percolation method to Slowly percolate at a speed of 1.5ml, collect the percolation liquid, then concentrate under red...

Embodiment 2

[0090] Embodiment 2 syrup

[0091] The preparation process of the syrup of the present invention is as follows: get 120g of tiger tail wheel, 160g of musk, 90g of seaweed, 180g of Liuyuexue, 240g of Niu Xixi, 150g of Tuolicao, 250g of lily, 150g of curcuma, 300g of coltsfoot flower, 180g of cassia seed, and 200g of Tongjingcao , Half money 120g, Frangipani 300g, Ganoderma lucidum 210g, Magnolia officinalis 180g, Puffball 140g, Fenxin wood 240g, Shenjin vine 150g, Halberd leaves Wawei 320g, Garlic 120g, Bougainvillea 90g, Chinese yam 200g, Acanthopanax 90g, Shanzhiren 170g, Herba Cistanche 250g, Viola 190g, and Pueraria 130g;

[0092] In the first step, mix Niu Xixi, Tuolicao, Lily and Curcuma according to the stated ratio, add ethanol with an alcohol concentration of 85% that is 5 times that of the mixture, heat and reflux for 3 times, each time reflux for 2.5 hours, and combine the extraction Use a tube centrifuge to remove impurities, concentrate the extracted extract under...

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Abstract

The invention discloses a medicine composition for treating infant spleen-deficiency type diarrhea and a preparing method of the medicine composition. The medicine composition is prepared from crinite uraria herb, musk, seaweed, snow of June herb, patience dock roots, fortune silene herb with roots, lily, rhizoma curcumae, common coltsfoot flowers, asiatic bilberry leaves, fructus hippophae, semen cassiae, slivery aleuritopteris herb, obcordate christia herb, plumeria acutifolia flowers, lucid ganoderma, officinal magnolia bark, panax notoginseng, bovista, diaphragma juglandis fructus, Chinese tinospora stems, spores of lepisorus waltonii (Ching) Ching, garlic, roots or leaves or fruits of zanthoxylum avicennae (Lam.)DC., yam, water chestnuts, nudicaulous poppy fruits or herb with flowers, manyprickle acanthopanax roots, glabrousleaf pittosporum seeds, boschniakia rossica, violet herba and fruits or leaves of vitis flexuosa thunb. The medicine composition for treating infant spleen-deficiency type diarrhea and the preparing method of the medicine composition have the advantages that the medicine composition has the effects of regulating vital energy and regulating the middle warmer, tonifying the spleen and invigorating the stomach, relaxing the bowels and clearing away heat and promoting diuresis, also has the functions of protecting the intestine and stomach mucosa, promoting appetite, enhancing resistance and arresting pain, and is fast in effect taking, high in effective rate, definite in treatment effect, short in treatment course, free of toxic or side effects, low in price and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating diarrhea of ​​spleen deficiency type in infants and a preparation method thereof. Background technique [0002] Infant diarrhea, also known as infant dyspepsia, is a syndrome of acute gastrointestinal dysfunction in infants and young children, mainly characterized by diarrhea and vomiting, with the highest incidence in summer and autumn. The pathogenic factors of this disease are divided into three aspects: constitution, infection and digestive disorder. The main clinical manifestations are increased stool frequency, loose stools, and water and electrolyte disturbances. If the disease is not treated in time, severe water and electrolyte imbalance may endanger the life of children. [0003] Causes of diarrhea in infants and young children: 1. Physical factors: This disease mainly occurs in infants and young children. ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/12A61P1/14A61P29/00A61K35/55
CPCA61K36/48A61K9/0095A61K9/1652A61K9/19A61K35/55A61K36/03A61K36/06A61K36/074A61K36/11A61K36/185A61K36/24A61K36/254A61K36/258A61K36/28A61K36/282A61K36/36A61K36/41A61K36/45A61K36/47A61K36/482A61K36/52A61K36/575A61K36/59A61K36/64A61K36/66A61K36/70A61K36/74A61K36/758A61K36/86A61K36/87A61K36/89A61K36/8945A61K36/8962A61K36/8967A61K36/9066A61K47/10A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 李可亮
Owner 李可亮
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