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Isoliquiritigenin pyrazinamide eutectic crystal and preparation method thereof

A technology of isoliquiritigenin and isonicotinamide is applied in directions such as organic chemistry, can solve the problems of limited application, low solubility of isoliquiritigenin, unsatisfactory oral intake and the like, and achieves the effects of improving solubility, low cost and simple preparation process

Inactive Publication Date: 2016-06-01
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of isoliquiritigenin is low, which leads to its unsatisfactory oral inhalation, which greatly limits its application in disease treatment.

Method used

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  • Isoliquiritigenin pyrazinamide eutectic crystal and preparation method thereof
  • Isoliquiritigenin pyrazinamide eutectic crystal and preparation method thereof
  • Isoliquiritigenin pyrazinamide eutectic crystal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Precisely weighed 128.17 mg of isoliquiritigenin and 61.06 mg of isonicotinamide were placed in a mortar, added 75 μl of methanol, and ground for 20 minutes to obtain isoliquiritigenin-isonicotinamide co-crystal.

Embodiment 2

[0031] Precisely weighed 135.49 mg of isoliquiritigenin and 64.56 mg of isonicotinamide were placed in a mortar, added 90 μl of ethanol, and ground for 40 minutes to obtain isoliquiritigenin-isonicotinamide co-crystal.

Embodiment 3

[0033] Precisely weigh 89.79 mg of isoliquiritigenin and 42.76 mg of isonicotinamide and place them in a mortar, add 60 μl of methanol, and grind for 35 minutes to obtain isoliquiritigenin-isonicotinamide co-crystal.

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PUM

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Abstract

The invention belongs to the technical field of medicine eutectic crystal, and concretely discloses an isoliquiritigenin pyrazinamide eutectic crystal and a preparation method thereof. According to the method, isoliquiritigenin and pyrazinamide are used as raw materials; a solvent auxiliary grinding method or a solvent suspension method is used for preparing the isoliquiritigenin pyrazinamide eutectic crystal. The obtained eutectic crystal has a novel crystal form, is favorable for novel preparation development, and promotes the application of the isoliquiritigenin to medicine clinics.

Description

technical field [0001] The invention relates to isoliquiritigenin-isonicotinamide co-crystal and a preparation method thereof, belonging to the field of drug co-crystal. Background technique [0002] Supramolecular chemistry has developed rapidly in recent decades and is considered to be one of the important sources of new concepts and technologies in the 21st century. As a branch of chemistry, it focuses on the non-covalent bond between molecules. Compared with the covalent bond studied in traditional chemistry, the research object of supramolecular chemistry is some weaker and more recoverable Intermolecular interactions such as hydrogen bonding, metal coordination, hydrophobic effects, van der Waals forces, and overlapping interactions. The core part of its research is the molecular recognition and supramolecular self-assembly through the synergy of weak intermolecular interactions. [0003] Crystal engineering applies the principles and methods of supramolecular chemis...

Claims

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Application Information

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IPC IPC(8): C07D213/81C07C49/835
CPCC07D213/81C07C49/835
Inventor 蔡挺秦昆明徐嘉黄雨婷蔡宝昌
Owner CHINA PHARM UNIV
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