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Hydroxylsafflor yellow A vesica and preparation method thereof

A hydroxysafflor yellow pigment technology, applied in microcapsules, capsule delivery, nanocapsules and other directions, can solve the problem of no reports of hydroxysafflor yellow A, and achieve reduced plasma clearance, prolonged circulation time, and drug loading. large amount of effect

Inactive Publication Date: 2016-05-25
QINGDAO UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydroxysafflower yellow A as an encapsulated drug combined with vesicles has not been reported at home and abroad

Method used

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  • Hydroxylsafflor yellow A vesica and preparation method thereof
  • Hydroxylsafflor yellow A vesica and preparation method thereof
  • Hydroxylsafflor yellow A vesica and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] formula:

[0029] Tween 200.29g

[0030] Cholesterol 0.06g

[0031] Hydroxysafflower yellow A solution 1.55mg / ml

[0032] Preparation Process:

[0033] Weigh the prescribed amount of Tween 20 and cholesterol into the ethanol solution, and stir at a certain speed on a magnetic stirrer to dissolve them all. Immediately, quickly inject this alcohol solution into 10 mL of hydroxysafflower yellow A solution placed in a constant temperature water bath at 55°C, stir at a constant speed until the ethanol evaporates completely, and filter through a 0.45 μm microporous membrane to obtain hydroxysafflower yellow A Anthocyanin A vesicle solution.

Embodiment 2

[0035] formula:

[0036] Tween 800.29g

[0037] Cholesterol 0.06g

[0038] Hydroxysafflower yellow A solution 1.55mg / ml

[0039] Preparation Process:

[0040] Weigh the prescribed amount of Tween 80 and cholesterol into the ethanol solution, and stir at a certain speed on a magnetic stirrer to dissolve them all. Immediately, quickly inject this alcohol solution into 10 mL of hydroxysafflower yellow A solution placed in a constant temperature water bath at 55°C, stir at a constant speed until the ethanol evaporates completely, and filter through a 0.45 μm microporous membrane to obtain hydroxysafflower yellow A Anthocyanin A vesicle solution.

Embodiment 3

[0042] formula:

[0043] Tween 600.29g

[0044] Cholesterol 0.06g

[0045] Hydroxysafflower yellow A solution 1.55mg / ml

[0046] Preparation Process:

[0047] Weigh the prescribed amount of Tween 80 and cholesterol into the ethanol solution, and stir at a certain speed on a magnetic stirrer to dissolve them all. Immediately, quickly inject this alcohol solution into 10 mL of hydroxysafflower yellow A solution placed in a constant temperature water bath at 55°C, stir at a constant speed until the ethanol evaporates completely, and filter through a 0.45 μm microporous membrane to obtain hydroxysafflower yellow A Anthocyanin A vesicle solution.

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Abstract

The invention discloses a hydroxylsafflor yellow A vesica and a preparation method thereof. According to the vesica, a hydroxylsafflor yellow A solution serves as a core material, and a nonionic surfactant and cholesterol serve as wall materials. The preparation method includes the steps that firstly, the nonionic surfactant and cholesterol are added into an ethanol solution, and the mixture is stirred in a magnetic stirrer at a maintained stirring speed to be completely dissolved; then, the ethanol solution is rapidly injected into a drug solution in a constant-temperature water bath, the mixture is stirred at a constant speed till ethanol volatilizes completely, the mixture is filtered with a 0.45 micrometer microporous filtration membrane, and a hydroxylsafflor yellow A vesica solution is obtained. The preparation method is good in reproducibility, easy to implement and convenient to control, and the prepared hydroxylsafflor yellow A vesica is large in drug loading capacity and low in plasma clearance and has the advantages of controlled release, lasting and stable plasma-drug concentration, safety, high efficiency and the like.

Description

technical field [0001] The invention relates to a hydroxysafflower yellow A vesicle and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Safflower is the dried flower of Safflower safflower, which is a traditional Chinese medicine for promoting blood circulation and removing blood stasis. In modern medicine, it is used to prevent and treat middle-aged and elderly diseases such as coronary heart disease, myocardial infarction and cerebral thrombosis. The main component of safflower is safflower yellow, among which hydroxy safflower yellow A is hygroscopic and belongs to chalcone glycosides, which has anticoagulation, blood circulation promoting, dissipating blood stasis and pain relief, and improving cardiovascular and cerebrovascular blood supply. Insufficient and so on. [0003] Hydroxysafflower yellow A is very water-soluble, and it is currently used clinically as an injection of its drug solutio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K31/351A61P9/10A61P7/02A61P29/00
CPCA61K9/5015A61K9/51A61K31/351
Inventor 张丹丹张小波黄山
Owner QINGDAO UNIV OF SCI & TECH
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