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A degradable silicon-based hybrid polymer biomedical elastomer and its preparation method

A biomedical and elastomer technology, applied in the field of biodegradable silicon-based hybrid polymer biomedical elastomer and its preparation, can solve the problems of lack of biological activity, unfavorable tissue repair, excessively fast degradation rate, etc., and achieve high biological stability properties, enhanced mechanical properties and elastic behavior, effects of high biological activity

Inactive Publication Date: 2017-04-26
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in recent years, PCD-based elastomers have the following disadvantages: first, low mechanical strength, especially compared with bone tissue; second, PCD is an aliphatic polyester elastomer, and its excessively fast degradation rate Especially in the in vivo environment, it hinders the practical application; third, the pure organic elastomer is not conducive to tissue repair due to the lack of biological activity

Method used

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  • A degradable silicon-based hybrid polymer biomedical elastomer and its preparation method
  • A degradable silicon-based hybrid polymer biomedical elastomer and its preparation method
  • A degradable silicon-based hybrid polymer biomedical elastomer and its preparation method

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Experimental program
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Effect test

Embodiment 1

[0037] 1) Preparation of PCD prepolymer: According to the molar ratio of citric acid: 1,8-octanediol is 1:1.1, the total mass is 5.0g, add it into a 50mL round bottom flask, stir it under nitrogen environment and put it in 160℃ Melt in an oil bath; after the reaction monomers citric acid and 1,8-octanediol are completely melted, immediately lower the temperature to 140°C, and react for 1 hour under a nitrogen atmosphere. The reaction product was washed 3 times with deionized water, centrifuged, and freeze-dried for future use;

[0038] 2) Preparation of PCD-g-POSS prepolymer: According to the molar ratio of citric acid: 1,8-octanediol: aminopropyl isobutyl POSS is 1:1.1:0.8, the total mass is 5.0g, add to In a 50mL round-bottomed flask, stir in a nitrogen atmosphere and melt in an oil bath at 160°C; after the citric acid and 1,8-octanediol are completely melted, immediately lower the temperature to 140°C and react for 1 hour in a nitrogen atmosphere. The reaction product was ...

Embodiment 2

[0042] 1) Preparation of PCD prepolymer: According to the molar ratio of citric acid: glycerol of 1:0.8, the total mass is 5.0g, add it into a 50mL round bottom flask, stir it under nitrogen environment and put it into a 160°C oil bath to melt; After the reaction monomers citric acid and glycerin were all melted, the temperature was immediately lowered to 142° C., and the reaction was carried out under an argon atmosphere for 1 hour. The reaction product was washed 3 times with deionized water, centrifuged, and freeze-dried for future use;

[0043] 2) Preparation of PCD-g-POSS prepolymer: According to the molar ratio of citric acid: glycerol: aminopropyl isobutyl POSS is 1:0.8:0.4, the total mass is 5.0g, join in the 50mL round bottom flask, Stir under nitrogen atmosphere and put into 160°C oil bath to melt; after the citric acid and glycerin are completely melted, immediately lower the temperature to 142°C, and react under nitrogen atmosphere for 1 hour. The reaction product...

Embodiment 3

[0047] 1) Preparation of PCD prepolymer: According to the molar ratio of citric acid:xylitol of 1:0.9 and the total mass of 5.0g, add it into a 50mL round bottom flask, stir it under nitrogen atmosphere and put it into an oil bath at 160°C to melt ; After the reaction monomers citric acid and xylitol are all melted, the temperature is immediately lowered to 145° C., and the reaction is carried out under a helium atmosphere for 1 hour. The reaction product was washed 3 times with deionized water, centrifuged, and freeze-dried for future use;

[0048] 2) Preparation of PCD-g-POSS prepolymer: According to the molar ratio of citric acid: xylitol: aminopropyl isobutyl POSS is 1:0.9:0.5, the total mass is 5.0g, add to a 50mL round bottom flask , stirred in a nitrogen atmosphere and melted in a 160°C oil bath; after the citric acid and xylitol were all melted, the temperature immediately dropped to 145°C and reacted for 1 hour under a nitrogen atmosphere. The reaction product was di...

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Abstract

The invention provides degradable silica-based hybrid polymer biomedical elastomer and a preparation method thereof. The degradable silica-based hybrid polymer biomedical elastomer (PCD-POSS) is obtained by preparing PCD prepolymer from citric acid, diol or polyhydric alcohol through thermal polymerization, preparing PCD-g-POSS prepolymer from acid, diol or polyhydric alcohol and POSS through thermal polymerization, dissolving the two types of prepolymer in organic solvent, and adding a cross-linking agent HDI and a catalyst for the cross-linking reaction. The thermal polymerization method used for the method is environmentally friendly, convenient to operate and low in raw material cost. The prepared PCD-POSS has biomimetic viscoelasticity, high chemical strength, good mechanical performance, high biological activity and biological stability, adherency and proliferation of osteoblast and soft tissue cells can be remarkably promoted, and the silica-based hybrid polymer biomedical elastomer has good application prospects in the fields of bone tissue and soft tissue regeneration and medicine transportation.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a degradable silicon-based hybrid polymer biomedical elastomer and a preparation method thereof. Background technique [0002] Human tissues such as bone tissue, muscle, skin and heart not only have a certain mechanical strength and self-repair function, but also have elastic behavior, which is an important guarantee for their physiological functions (Fong E.L, Watson B.M, Kasper F.K, Mikos A.G.Adv Mater.2012; 24:4995-5013; Puppi D, Chiellini F, PirasA.Prog.Polym.Sci.2010; 35:403-440.), therefore, biomedical materials should be able to simulate the mechanical behavior of tissue and biological activity, so as to ensure the actual needs in clinical application. [0003] In recent years, based on organic polymers, elastomers that mimic tissue elastic behavior, such as poly 1,3-trimethylene carbonate (PTMC), polyglycerol-sebacic acid (PGS), polyci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/695C08G63/06C08G63/78C08J3/24
CPCC08G63/06C08G63/6952C08G63/78C08J3/246C08J2367/04
Inventor 雷波杜玉章于萌
Owner XI AN JIAOTONG UNIV
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