Water-soluble and degradable cross-linking agent, preparation method of gamma-polyglutamic acid water absorbing material using cross-linking agent

A technology of polyglutamic acid and water-absorbing materials, which is applied in the field of polymer chemistry, can solve problems such as inconvenience, and achieve the effects of simple steps, active reactivity, and easy-to-obtain raw materials

Inactive Publication Date: 2016-04-13
新疆康润洁环保科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan is insoluble in water and alkaline solutions, and it is inconvenient to prepare hydrogels as a crosslinking agent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1) Weigh 1g of chitosan oligosaccharide, 0.9g of EDC and 0.6g of NHS and dissolve them in 30mL of dilute hydrochloric acid with pH=5.2, stir until completely dissolved, add 0.98g of acrylic acid, and stir magnetically for 96h at room temperature. After the reaction was completed, the reaction product was slowly poured into 180 mL of absolute ethanol, stirred to make the chitosan oligosaccharide derivative fully precipitated, vacuum filtered, and the filter cake was naturally dried to obtain an acrylic acid grafted chitosan oligosaccharide cross-linking agent (cross-linking agent). agent 1).

[0044] 2) Dissolve 120 mg of γ-polyglutamic acid in 2 mL of deionized water, add 40 mg of cross-linking agent 1, mix well, then add 1.3 mg of initiator ammonium persulfate and 10 μL of cross-linking accelerator as N, N, N', N '-Tetramethylethylenediamine, polymerized at room temperature for 10h to form a hydrogel-like water-absorbing material, placed in deionized water for repeated...

Embodiment 2

[0046]1) Weigh 1 g of chitosan oligosaccharide, 0.9 g of EDC, and 0.6 g of NHS and dissolve them in 30 mL of dilute hydrochloric acid with pH=4.7, stir until completely dissolved, add 0.98 g of acrylic acid, and stir magnetically for 72 h at room temperature. After the reaction was completed, the reaction product was slowly poured into 180 mL of absolute ethanol, stirred to make the chitosan oligosaccharide derivative fully precipitated, vacuum filtered, and the filter cake was naturally dried to obtain an acrylic acid grafted chitosan oligosaccharide cross-linking agent (cross-linking agent). agent 2).

[0047] 2) Dissolve 120 mg of γ-polyglutamic acid in 2 mL of deionized water, add 40 mg of cross-linking agent 2, mix well, then add 1.0 mg of initiator potassium persulfate and 10 μL of cross-linking accelerator as N, N, N', N '-Tetramethylethylenediamine, polymerized at room temperature for 11h to form a hydrogel-like water-absorbing material, placed in deionized water for r...

Embodiment 3

[0049] 1) Weigh 1g of chitosan oligosaccharide, 0.9g of EDC and 0.6g of NHS and dissolve them in 30mL of dilute hydrochloric acid with pH=5.0, stir until completely dissolved, add 0.49g of acrylic acid, and stir magnetically for 48h at room temperature. After the reaction was completed, the reaction product was slowly poured into 180 mL of absolute ethanol, stirred to make the chitosan oligosaccharide derivative fully precipitated, vacuum filtered, and the filter cake was naturally dried to obtain an acrylic acid grafted chitosan oligosaccharide cross-linking agent (cross-linking agent). agent 3).

[0050] 2) Dissolve 120 mg of γ-polyglutamic acid in 2 mL of deionized water, add 40 mg of cross-linking agent 3, mix well, then add 1.6 mg of initiator ammonium persulfate and 10 μL of cross-linking accelerator as N, N, N', N '-Tetramethylethylenediamine, polymerized at room temperature for 8 hours to form a hydrogel-like water-absorbing material, placed in deionized water for repe...

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PUM

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Abstract

The invention discloses a preparation method of gamma-polyglutamic acid water absorbing material. Gamma-polyglutamic acid is used as a main raw material, chitosan oligosaccharide-graft-acrylic acid is used as a biodegradable cross-linking agent, and the gamma-polyglutamic acid hydrogel water absorbing material is obtained after preparation in an aqueous solution. The biodegradable cross-linking agent replaces a common chemical cross-linking agent for preparing the hydrogel, the reaction medium is free of toxic organic solvents, gamma-polyglutamic acid which is safe and nontoxic is used as the main raw material, the water-soluble and degradable chitosan oligosaccharide-graft-acrylic acid is used as a cross-linking agent, and the gamma-polyglutamic acid water absorbing material is prepared in the aqueous solution. The raw materials and mediums do not have harmful substances for human body, the safe, nontoxic and biodegradable hydrogel is obtained, and the hydrogel can be applied to disposable hygiene products, drug carriers, medical articles, etc.

Description

technical field [0001] The invention relates to an acrylic acid grafted chitosan oligosaccharide cross-linking agent and a preparation method thereof, and a method for preparing a γ-polyglutamic acid water-absorbing material by using the cross-linking agent, belonging to the field of polymer chemistry. Background technique [0002] γ-Polyglutamic acid, referred to as γ-PGA, is a homopolymeric amino acid that can be synthesized by fermentation of a variety of bacilli, and is the main component of some microbial capsules. 5 ~10 6 between. A polyglutamic acid composed of D- and L-glutamic acids linked by γ-amide bonds. The polymer structure contains -COOH reactive groups, so it has strong water absorption. [0003] γ-Polyglutamic acid water-absorbing material is a biodegradable hydrogel, which is a kind of functional polymer material with three-dimensional network after moderate cross-linking, hydrophilic but insoluble in water. Because of its high swelling property, non-tox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F220/06C08J3/24C08J3/075C08L77/04C08L51/02
CPCC08F251/00C08J3/075C08J3/24C08L77/04C08L2201/06C08F220/06C08L51/02
Inventor 孔立明陈志伟
Owner 新疆康润洁环保科技股份有限公司
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