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Curcumin composite particle and preparation method and application thereof

A technology of composite particles and curcumin, applied in the biological field, can solve problems such as hidden dangers of biological safety

Active Publication Date: 2016-04-06
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the currently selected materials are synthetic polymers or lipid materials (containing surfactants), and their biological safety has hidden dangers

Method used

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  • Curcumin composite particle and preparation method and application thereof
  • Curcumin composite particle and preparation method and application thereof
  • Curcumin composite particle and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Preparation of gliadin-sodium caseinate nanoparticles

[0118] The zein was dissolved with 80% (v / v) ethanol aqueous solution, wherein the mass concentration of the zein was 20 mg / mL. A certain amount of the above-mentioned aqueous alcohol solution was dropped into an aqueous solution of sodium caseinate with a mass concentration of 2 mg / mL, and the mass ratios of zein (Zein) and sodium caseinate (NaCas) in the mixed system were respectively 1:0.1, 1:0.25, 1:0.35, 1:0.5, 1:0.625, 1:0.8, 1:1.0, 1:1.25. After magnetic stirring for a period of time, the ethanol was blown dry with a nitrogen blower to obtain gliadin-sodium caseinate nanoparticles.

[0119] The result is as follows:

[0120] When the addition ratio of Zein and NaCas is 1:0.1~1:0.25, the precipitate visible to the naked eye is deposited on the bottom of the bottle instantaneously; as the addition ratio of NaCas increases to 1:0.35~1:0.5, a milky white dispersion system can be formed , but after the above s...

Embodiment 2

[0124] Stability experiment of gliadin-sodium caseinate nanoparticles

[0125] The gliadin-sodium caseinate nanoparticles prepared in Preliminary Example 1 were freeze-dried and redissolved in 2M NaCl aqueous solution and 40% (w / v) sucrose aqueous solution respectively, and the morphology of the reconstituted nanoparticles was observed with a transmission electron microscope.

[0126] The result is as Figure 10 As shown, prolamin-sodium caseinate nanoparticles redissolved in aqueous NaCl and sucrose still maintained their spherical morphology in water. The surface of nanoparticles reconstituted in sucrose solution was smooth; while the surface of nanoparticles reconstituted in NaCl was slightly rough and angular, which may be due to the deposition of salt crystals on the surface of nanoparticles during the drying process during sample preparation.

[0127] Example 1

[0128] Preparation of Curcumin Nanosystem

[0129] The zein and curcumin were dissolved with 80% (v / v) eth...

Embodiment 3

[0140] In Vitro Release Experiment of Curcumin Nanosystem

[0141] Configure three release media: simulated artificial gastric juice, simulated artificial small intestine fluid and simulated artificial colonic fluid. Among them, simulated artificial gastric juice: dilute 2g sodium chloride and 7mL concentrated hydrochloric acid to 1000mL with double distilled water, and adjust the pH to 1.2; simulated artificial small intestine juice: weigh 6.8gKH 2 Dissolve PO4 in 250mL double-distilled water, add 190mL0.2mol / L NaOH and 400mL double-distilled water, mix well and then use double-distilled water to adjust the pH to 7.4; KH with a concentration of 0.05mol / L 2 PO4 solution, and adjust the pH to 6.0. Due to the low solubility of curcumin in water, in order to meet the sink condition, a certain amount of Tween was added to the above three release media, and it was configured as simulated artificial gastric juice containing 1% (w / v) Tween, artificial Intestinal fluid and artifici...

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Abstract

The invention provides a curcumin composite particle and a preparation method and application thereof. In particular, the curcumin composite particle comprises component (a) curcumin, component (b) prolamin and component (c) casein or caseinate or casein derivative. The component (a) and the component (b) are in a mixed state and wrapped by the component (c). The curcumin composite particle can remarkably improve the water solubleness, bioavailability and stability of the curcumin, and has good application prospects in the field of functional food and medicine.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a curcumin composite granule and its preparation method and application. Background technique [0002] Curcumin is a polyphenolic compound extracted from the rhizome of the perennial herb turmeric. Traditional curcumin is generally used as food dyes and additives. In recent years, a large number of studies have shown that curcumin has a wide range of physiological activities. , such as lowering blood fat, anti-tumor, anti-inflammatory, choleretic, anti-oxidation, etc. However, the solubility of curcumin in aqueous environment is extremely poor and unstable; in addition, curcumin is also sensitive to light and heat, these factors greatly restrict the application of curcumin in different fields. The water solubility and stability of curcumin can be greatly improved by selecting suitable materials to construct curcumin-loaded nanosystems. Most of the currently selected materials are s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/16A61K31/12A61K47/42A61P3/06A61P35/00A61P1/16A61P39/06A23L2/02A23L2/52A23L2/66A23L33/17A23L33/185A23L33/105A23C9/152A23C11/08A23F3/14A23F5/14
CPCA23C9/152A23C9/1526A23C11/08A23F3/14A23F5/14A23L2/02A23L2/52A23L2/66A23V2002/00A61K9/146A61K9/1658A61K31/12A23V2200/16A23V2200/242A23V2200/3262A23V2200/30A23V2250/032A23V2250/21A23V2250/2112A23V2250/2482A23V2250/26A23V2250/5042A23V2250/5086A23V2250/51084A23V2250/51088A23V2250/5112A23V2250/5118A23V2250/54246A23V2250/548A23V2250/606A23V2250/61A23V2250/612A23V2250/616A23V2250/628A23V2250/6402A23V2250/6418A23V2250/642A23V2250/6422
Inventor 张亚琼姚芳懿
Owner SHANGHAI JIAO TONG UNIV
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