Antibacterial composite material, preparation method and application thereof

A composite material and carbon material technology, applied in the field of antibacterial composite materials, can solve the problems of common urinary catheters that do not have bactericidal effect, easily cause urinary system infection, environmental heavy metal pollution, etc., to prevent infection problems, reduce medical costs, Easy to operate effect

Active Publication Date: 2016-03-23
郑州欧姆康生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial effect is short. For patients who need to indwell the catheter for a long time, it is easy to cause urinary system infection and bring more pain to the patient. Ordinary catheters have no bactericidal effect and are more likely to cause urinary system infection.
[0008] In addition, during the process of processing and the preparation of urinary catheters, as solid powder or other forms, nano-silver particles can enter the human body through the respiratory tract, digestive tract, skin and direct embedding, causing potential harm to the human body; silver ions also It will cause heavy metal pollution to the environment and bring huge damage to water bodies

Method used

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  • Antibacterial composite material, preparation method and application thereof
  • Antibacterial composite material, preparation method and application thereof
  • Antibacterial composite material, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Preparation of quaternized polyethyleneimine amphiphilic bio-carbon material particles

[0042] (1) Shake 10g of yeast to disperse, take the gray-white bacterial suspension in the upper layer and centrifuge, discard the waste liquid, then add 20ml of acetone, shake for 5-20min, centrifuge, discard the acetone, repeat the same method 3-5 times , disperse the substrate with 2% glutaraldehyde aqueous solution, pour it into a high-temperature and high-pressure reactor, and react at 150-200°C for 8-10h. After the reaction, cool to room temperature, pour off the upper layer solution, and use the lower layer precipitation Repeated ultrasonic washing with distilled water, and finally drying in an oven to obtain amphiphilic bio-carbon material particles.

[0043] (2) Weigh 200 mg of amphiphilic bio-carbon material particles and ultrasonically disperse them in 20 ml of PB buffer solution (PH5.5), and add an appropriate amount of 1-(3-dimethylaminopropyl)-3-ethylcarbodie...

Embodiment 2

[0045] Embodiment 2 prepares quaternized polyethyleneimine carbon slag particle / silicone rubber mixture

[0046] Add 50 mg of quaternized polyethyleneimine carbon slag particles into 5 g of silicone rubber liquid at a mass fraction of 1:100, and mix well;

[0047] 1. Preparation of antibacterial silicone rubber catheter

[0048] The above mixture is made into a novel antibacterial urinary catheter according to the preparation process of a conventional urinary catheter.

[0049] 2. Tensile properties, tear properties, elastic modulus, elongation at break and Shore A hardness test results

[0050]

[0051] 3. Antibacterial effect test results

[0052] Escherichia coli (E.coli) isolates were selected as Gram-negative bacteria for testing the antibacterial activity of the membrane and Staphylococcus aureus (S.aureus) isolates were selected as Gram-positive bacteria for testing the antibacterial activity of the membrane, antibacterial particles Test results such as Figure 4...

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PUM

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Abstract

The invention discloses an antibacterial composite material, which is composed of an antibacterial amphiphilic biological carbon material and resin. The antibacterial amphiphilic biological carbon material is prepared by modifying the surface of an amphiphilic biological carbon material with quaternized polyethyleneimine through a covalent bond with the amphiphilic biological carbon material as a carrier. Hydrophobic resin is uniformly doped with the antibacterial amphiphilic biological carbon material to form the antibacterial composite material. A preparation method is simple in process and easy to carry out. The novel antibacterial material is ecological and environment-friendly, is toxic-free and is not liable to permeate through skin. A finish product is durable and stable in antibacterial effect. When being used for producing medical apparatus and instruments, such as catheters and the like, the antibacterial composite material can significantly reduce the infection rate of urinary system, thereby reducing patient suffering and reducing treatment cost. The invention also discloses the preparation method of the composite material.

Description

technical field [0001] The invention relates to an antibacterial composite material, in particular to an antibacterial urinary catheter. Background technique [0002] The surface non-specific adsorption / adhesion of protein / bacteria is an important reason for the formation of biofouling on the surface of utensils. Usually, proteins will first non-specifically adsorb on the surface of the material to form a conditioned layer, which in turn causes bacterial adhesion, reproduction, and eventually the formation of a biofilm. In this research field, people currently mainly adopt the strategy of grafting hydrophilic polymers on the surface to deal with the dual challenges of proteins and bacteria. These hydrophilic polymers include polyethylene glycol / polyoxyethylene, polyhydroxyethyl methacrylate, etc. And poly N-(2-hydroxypropyl) methacryloyl, carboxybetaine zwitterionic copolymer, etc. Although the surface of these hydrophilic polymers can induce the formation of a hydration f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L83/04C08K9/04C08K3/04
CPCC08K3/04C08K9/04C08L83/04
Inventor 吴强李旭鹏杨凯
Owner 郑州欧姆康生物材料有限公司
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