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Pentacyclic triterpene compound and application thereof

A technology for pentacyclic triterpenoids and compounds is applied in the field of pentacyclic triterpenoids, which can solve the problems of insufficient research on chemical constituents, and achieve the effects of good anti-inflammatory activity and good safety.

Active Publication Date: 2016-03-23
GUANGDONG PHARMA UNIV
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  • Abstract
  • Description
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Problems solved by technology

[0005] The main anti-inflammatory active components of Quercus brevifolia seeds are triterpenoids, and the existing research on its chemical constituents is still not thorough enough, so the chemical composition of triterpenoids in Quercus brevicense seeds is worthy of further research and development

Method used

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  • Pentacyclic triterpene compound and application thereof
  • Pentacyclic triterpene compound and application thereof
  • Pentacyclic triterpene compound and application thereof

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Embodiment Construction

[0027] The technical solutions of the present invention will be further described below in conjunction with the embodiments.

[0028] Take 34.5Kg of Quercus brevifolia seeds, heat and reflux extraction with 70% ethanol for 4 times, each time for 4 hours, combine the extracts and recover the solvent under reduced pressure to obtain a total concentrated solution of 30L, and use cyclohexane, ethyl acetate and n-butanol successively Equal volumes were extracted 4 times each, and 200 g of the ethyl acetate layer extract was obtained. Compound 1-4 of the present invention was obtained by separating from the ethyl acetate layer extract by using separation methods such as silica gel column chromatography, SephdaxLH-20 gel chromatography, ODS medium and low pressure column chromatography, and reverse-phase high-performance liquid chromatography. The structures of the above four compounds were identified by physical and chemical constants and modern spectroscopy methods (HRESIMS, 1D-NMR...

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Abstract

The invention discloses a pentacyclic triterpene compound and application thereof. The structural general formula of the pentacyclic triterpene compound is shown in the description, wherein the R11 and the R21 independently represent alkyl, hydroxymethyl or their esters, and the R31 and the R41 independently represent hydrogen and alkyl. The pentacyclic triterpene compound has a good anti-inflammatory effect, has the advantages of high efficiency and low toxicity and is expected to develop into a new anti-inflammatory drug and a functional food beneficial to patients suffering from inflammation.

Description

technical field [0001] The invention relates to a pentacyclic triterpene compound and its application. Background technique [0002] Inflammation is a defense-based response of living tissue with vascular system to inflammatory factors. Inflammatory diseases are common clinical diseases, such as furuncle, carbuncle, pneumonia, gastritis, hepatitis, nephritis, typhoid fever, tuberculosis, etc. Local clinical manifestations include redness, swelling, heat, pain and dysfunction; the whole body often has reactions of varying degrees, such as fever and peripheral blood leukocytosis. Non-steroidal anti-inflammatory drugs (NSAIDs) are a large class of anti-inflammatory drugs commonly used clinically. In recent years, it has been found that their adverse reactions have been increasing, including gastrointestinal tract, nervous system, allergic reactions, liver and kidney damage, etc., among which The highest incidence of gastrointestinal adverse reactions, about 30% to 50%. Almos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00C07J63/00A61K31/7048A61P29/00
CPCC07J63/008C07J71/0005C07J71/0026
Inventor 何祥久黄洁王宜海李船
Owner GUANGDONG PHARMA UNIV
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