An analysis device and method for online determination of trace fluoride ions in blood samples

Abstract

The invention discloses an analysis device and method for determining trace fluorine ions in a blood sample online. The device comprises a membrane assisted distillation pre-treatment assembly and an ion chromatography system, wherein the membrane assisted distillation pre-treatment assembly is connected with the ion chromatography system through a constant-flow pump of the membrane assisted distillation pre-treatment assembly; the membrane assisted distillation pre-treatment assembly mainly comprises an ultrasonic assisted heating device, a hollow fiber membrane reactor and a constant-flow pump; the ultrasonic assisted heating device is arranged in the heating device and is provided with four connectors capable of being sealed; and the ultrasonic assisted heating device is communicated with the hollow fiber membrane reactor through the connectors of the hollow fiber membrane reactor. According to the analysis device and method, by adopting the self-made membrane assisted distillation pre-treatment assembly and searching conditions, online automation of a pre-treatment method is realized; and the pre-treatment method is combined with an ion chromatography, so that the online automatic analysis of the fluorine ions in a complicated sample is realized and the method is accurate and rapid and has high sensitivity.

Description

technical field [0001] The invention relates to a design method for on-line determination of trace fluoride ions in blood samples, in particular to a device and method for detecting trace fluoride ions in blood by membrane-assisted distillation on-line coupled with an ion chromatography analysis system. Background technique [0002] Fluorine is an essential trace element for the human body. The fluorine content in the normal human body is 2.6g, and the average fluorine content in the human body is 37×10 -6 to 70×10 -6 . The fluorine in the human body exists in the form of ionic fluoride, and 90% of the fluorine is distributed in the bone in the form of inorganic fluoride, and fluorine is also distributed in the skin, lung, kidney, heart, spleen, liver and other tissues and organs. The fluorine absorbed from the stomach quickly enters the blood, participates in blood circulation in the form of fluoride, and enters tissues, saliva, and kidneys. [0003] For the human body, ...

AI Technical Summary

Problems solved by technology

According to the characteristic that ionic fluoride is easy to form low-boiling hydrofluoric acid after acidification, under normal circumstances, simple fluorine-containing sample solutions can be directly enriched and purified by distillation, and the matrix can be eliminated while enriching fluoride ions However, for samples with a relatively complex matrix, such as biological blood samples, urine samples, etc., the effect of the direct distillation method is not ideal. A large number of biological macromolecules and organic substances are often carried out during evaporation, which cannot completely eliminate the interference of the matrix.

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