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Surface-modified microcrystalline cellulose and preparation method thereof

A technology of microcrystalline cellulose and surface modification, applied in the field of pharmaceutical auxiliary preparation, can solve problems such as easy adsorption and poor dispersibility, and achieve the effects of good formability, good redispersibility, and resistance to static electricity

Active Publication Date: 2016-02-03
ANHUI SUNHERE PHARMA EXCIPIENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the defects of conventional microcrystalline cellulose such as poor dispersion in water, easy product static electricity, and easy adsorption, the surface of microcrystalline cellulose is physically treated, and polyethylene glycol is coated on the surface of microcrystalline cellulose, aiming at Provide a method for preparing modified microcrystalline cellulose products that are different from ordinary microcrystalline cellulose in that they can be better dispersed in water, have better reprocessability, and are less likely to generate static electricity, so as to be used in a wider space Foundation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The preparation method of a surface-modified microcrystalline cellulose in this embodiment is as follows: take 200 g of refined cotton, and tear it into small pieces of less than 2 cm for later use. Prepare 2.5L of 0.5mol / L hydrochloric acid, place it in a 3L Erlenmeyer flask, start stirring, and put refined cotton into the flask, connect the reflux device, continue stirring, turn on the heating system, heat the solution to 100°C, and reflux for 70 minutes. Cool, filter with suction, wash with pure water until the pH is 5.0-7.0, extract as much water as possible, and set aside. In a 2000ml clean beaker, add 1000ml of pure water, start stirring, add 5g of polyethylene glycol 400 (PEG-400), stir for 30 minutes, then add the above-mentioned cleaned materials into the beaker in batches, add while adding Stir for 60 minutes to make a uniform slurry, and the solid content of the white slurry is 10-30%. Spray drying at a drying temperature of 110-190° C., specifically 130° C....

Embodiment 2

[0045]A method for preparing surface-modified microcrystalline cellulose in this embodiment, the preparation process is as follows: take 20 kg of wood pulp board, cut it into small pieces below 3 cm for later use. Prepare 200kg of 0.4mol / L hydrochloric acid, place it in a 300L reaction kettle, start stirring, put the prepared wood pulp board into the kettle, continue stirring, heat the solution to 95°C, and keep it warm for 90 minutes. Cool to below 50°C, press filter, wash with pure water until the pH is 5.0 to 7.0, and prepare for later use. In a clean kettle of about 200L, add 100kg of pure water and 800g of polyethylene glycol 2000 (PEG-2000), stir to dissolve, then add the above-mentioned cleaned materials into the kettle in batches, and stir while adding, so that Form a uniform slurry, continue to stir for 60 minutes, adjust equipment parameters, and spray dry at a drying temperature of 150°C to obtain a surface PEG-modified microcrystalline cellulose product.

Embodiment 3

[0047] The preparation method of a kind of surface-modified microcrystalline cellulose of the present embodiment, its preparation process is: step 1, preparation concentration is 80kg of the phosphoric acid solution of 1.0mol / L, standby; Step 2, the wood pulp board of 2kg, Cut (or tear) 2kg of refined cotton into small pieces below 3cm for later use; step 3, add the phosphoric acid solution in step 1 into a 100L reaction kettle, start stirring, put the prepared material into the kettle, continue stirring, and heat to a solution of 90 ℃, keep warm for 20 minutes. Cool to below 50°C, press filter, wash with pure water until the pH is 5.0 to 7.0, and prepare for later use. In a clean tank of about 50L, add 25kg of pure water and 200g of polyethylene glycol 4000 (PEG-4000), stir to dissolve, then add the above-mentioned cleaned materials into the tank in batches, and stir while adding, so that Form a uniform slurry, continue to stir for 60 minutes, adjust equipment parameters, an...

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Abstract

The invention discloses surface-modified microcrystalline cellulose and a preparation method thereof, and belongs to the field of adjuvant preparation. The preparation method includes the steps that an inorganic acid solution is prepared for use; plant fiber is cut into proper dices for use; the inorganic acid solution is added into a reaction device, stirring is started, the plant fiber is put in and continuously stirred, a heating system is started to heat the solution till the solution nearly boils, and a heat preservation reaction is performed for certain time; a product formed after the reaction is filtered, and a filter cake is washed till the washing water is nearly neutral; pure water is added into a mixing device, stirring is started, polyethylene glycol is put in and stirred for 30 min, the materials are added into the mixing device, stirring continues to be performed for 60 min, and white uniform slurry is obtained; spray drying equipment is started for spray drying, and then the surface-modified microcrystalline cellulose product is obtained. The technology is simple, large-scale production is easy, and the obtained product is good in redispersibility and can be evenly dispersed in water more easily; the product is not likely to produce static and is better in formability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical auxiliary preparation, and relates to a modified microcrystalline cellulose product and a preparation method, in particular to a preparation method of microcrystalline cellulose whose surface is modified by a physical method. Background technique [0002] Microcrystalline cellulose (MCC) is a linear polysaccharide bound by β-1,4 glucosidic bonds. It is a free-flowing white or near-white powder obtained by dilute acid hydrolysis of natural cellulose. or granular solids. The degree of polymerization is 15-350, not fibrous but fluid. Insoluble in water, dilute acids, organic solvents and oils, partially soluble and swelling in dilute alkali solutions, and has high reactivity in the process of carboxymethylation, acetylation and esterification. [0003] Microcrystalline cellulose is a natural product, and its production and application have unique advantages. It has been widely used in medicine, food,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/00C08L1/02
Inventor 尹正龙刘强夏叶青毕勇
Owner ANHUI SUNHERE PHARMA EXCIPIENTS
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