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Pharmaceutical composition with efficacy of reducing blood fat and preparation method of pharmaceutical composition

A blood lipid-lowering drug and composition technology, applied in the field of medicine, can solve the problems of large differences in blood lipid lowering, small proportion of lovastatin, complex components of red yeast rice, etc.

Active Publication Date: 2016-01-27
HUNAN SHENTAICHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition of red yeast rice is complex, and most of the published studies have shown that lovastatin, the main hypolipidemic active ingredient, has a small proportion in red yeast rice
In the course of the research, the inventor found that the compound recipe composed of red yeast rice and eucommia seed oil has a very large difference in blood lipid lowering produced by different compatibility compositions. As the main raw material of the pharmaceutical composition, its application in reducing blood lipid has not been publicly reported. The applicant conducted animal drug efficacy tests and toxicological tests on the product and found that it has good blood lipid reducing effect and good safety

Method used

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  • Pharmaceutical composition with efficacy of reducing blood fat and preparation method of pharmaceutical composition
  • Pharmaceutical composition with efficacy of reducing blood fat and preparation method of pharmaceutical composition
  • Pharmaceutical composition with efficacy of reducing blood fat and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0202] Example 1 (soft capsule)

[0203] formula:

[0204] 1. Cyst fluid:

[0205] Monascus powder 1.464kg (measured lovastatin content 0.51%)

[0206] Eucommia ulmoides seed oil 0.732kg (pulverize eucommia seeds to 40 mesh, extraction pressure 35MPa, CO 2 The flow rate was 25kg / h, the extraction temperature was 25°C, the extraction was 2.5h, the separation pressure was 8MPa, and the separation temperature was 45°C. Alpha-linolenic acid oil content of 67.4%)

[0207] Propolis 0.144kg

[0208] 1.2kg of Panax notoginseng extract (equivalent to 10kg of raw medicinal materials of Panax notoginseng) (extract Panax notoginseng coarse powder with 8 times the weight of 70% ethanol for 2 times, each time for 2 hours, combine the alcohol extracts, remove alcohol, and pass through D101 Type macroporous resin adsorption, first eluted with water until the effluent water does not appear purple ring reaction, then eluted with 80% ethanol, collected the eluate, concentrated and dried to ...

Embodiment 2

[0219] Example 2 (dropping pills)

[0220] formula

[0221] 1. Main ingredients:

[0222] Monascus powder 1.464kg (measured lovastatin content 0.54%)

[0223] Eucommia ulmoides seed oil 0.732kg (pulverize eucommia seeds to 60 mesh, extraction pressure 40MPa, CO 2 The flow rate is 30kg / h, the extraction temperature is 30°C, the extraction is 3h, the separation pressure is 10MPa, and the separation temperature is 50°C. Alpha-linolenic acid oil content 66.5%)

[0224] Propolis 0.144kg

[0225] 1.2kg of Panax notoginseng extract (equivalent to 10kg of raw medicinal materials of Panax notoginseng) (extract 3 times of Panax notoginseng coarse powder with 6 times the weight of 75% ethanol for 2 hours each time, combine the alcohol extracts, remove alcohol, pass through D101 Type macroporous resin adsorption, first eluted with water until the effluent water does not appear purple ring reaction, then eluted with 70% ethanol, collected the eluate, concentrated, and dried to obtain)...

Embodiment 3

[0233] Embodiment 3 (soft capsule)

[0234] formula:

[0235] 1. Cyst fluid:

[0236] Monascus powder 1.464kg (measured lovastatin content 0.51%)

[0237] Eucommia ulmoides seed oil 0.732kg (pulverize eucommia seeds to 40 mesh, extraction pressure 35MPa, CO 2 Flow rate 25kg / h, extraction temperature 25℃, extraction 2.5h, separation pressure 8MPa, separation temperature 45℃, measured α-linolenic acid oil content 66.1%)

[0238] Propolis 0.144kg

[0239] 1.32kg of Panax notoginseng extract (equivalent to 10kg of raw medicinal materials of Panax notoginseng) (extracted Panax notoginseng coarse powder with 8 times the weight of 70% ethanol for 2 times, each time for 2 hours, combined the alcohol extracts, removed alcohol, concentrated, dried)

[0240] Beeswax 0.2kg

[0241] Soybean oil 8.8kg

[0242] 2. Capsule

[0243]

[0244]

[0245] Preparation method: same as Example 1

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Abstract

The invention provides a pharmaceutical composition with the efficacy of reducing blood fat. The pharmaceutical composition is prepared from the following components in parts by weight: 130-160 parts of red konjic rice powder, 65-80 parts of eucommiae ulmoides seed oil, 13-16 parts of propolis, 880-1110 parts of pseudo-ginseng or pseudo-ginseng extract, and a pharmaceutically acceptable adjuvant. The invention further discloses a preparation method of the pharmaceutical composition. The animal pharmacodynamic test proves that the pharmaceutical composition has the relatively good efficacy of reducing blood fat.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for lowering blood lipids. Background technique [0002] In recent years, there are many drugs, health food, food and other products with hypolipidemic effect under research or on the market. Among them, there are many traditional Chinese medicines or traditional Chinese medicine compounds with hypolipidemic effect. However, due to the differences in the active ingredients of different traditional Chinese medicines effects, as well as the side effects of some traditional Chinese medicines, etc., have resulted in few effective and safe pharmaceutical composition products. [0003] In recent years, more research and development of Eucommia ulmoides seed oil and red yeast rice have been carried out, and some products have been popularized. The oil content of Eucommia seeds is about 30%, and Eucommia seed oil is rich in alpha-linolenic acid. The comp...

Claims

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Application Information

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IPC IPC(8): A61K36/46A61K9/48A61K9/20A61P3/06A61K35/64
Inventor 张水寒左晶晶周融融刘静周泽
Owner HUNAN SHENTAICHUN PHARMA
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