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Nanometer material used for photothermal therapy and preparation method thereof

A technology of nanomaterials and photothermal therapy, which is applied in the direction of nanotechnology, nanotechnology, and nanotechnology for materials and surface science. It can solve problems affecting photothermal conversion efficiency and achieve high photothermal conversion efficiency and photothermal treatment. High conversion efficiency and good biocompatibility

Inactive Publication Date: 2016-01-13
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is reported that increasing Cu 2-x The size of S nanoparticles can enhance the light-to-heat conversion efficiency, which indicates that the operation of assembling nanocrystals will affect the local surface plasmon resonance effect and the resulting light-to-heat conversion efficiency

Method used

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  • Nanometer material used for photothermal therapy and preparation method thereof
  • Nanometer material used for photothermal therapy and preparation method thereof
  • Nanometer material used for photothermal therapy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a. Mix 6ml of oleylamine (OAM), 4ml of octadecene (ODE) and 0.08ml of dodecanethiol (DDT) and stir slowly, and inject 15mg of Cu(S 2 CNBut 2 ) precursor, kept at 190°C for 10min;

[0023] b. After the reaction is naturally cooled, take out the reaction solution and centrifuge (15000 rpm) for 10min to obtain hydrophobic Cu 7 S 4 nanocrystals, then dispersed in 1ml chloroform;

[0024] c. Add 30mgPSI to 10mL10mM NaOH aqueous solution OAm and 1 mg hydrophobic Cu 7 S 4 Chloroform dispersion of nanocrystals, ultrasonic (500W, 6 minutes);

[0025] d. Stir at 60° C. for 2 hours to distill off the chloroform, centrifuge (12000 rpm) for 10 minutes to obtain sheet-shaped photothermally treated nanomaterials, and redisperse them in 2 ml of deionized water.

Embodiment 2

[0027] a. Mix 4ml oleylamine (OAM), 6ml octadecene (ODE), 13mg thioacetamide (TA) and 0.1ml dodecanethiol (DDT) and stir slowly, inject 15mg of Cu(S 2 CNBut 2 ) precursor, kept at 145°C for 60min;

[0028] b. After the reaction is naturally cooled, take out the reaction solution and centrifuge (15000 rpm) for 10min to obtain hydrophobic Cu 7 S 4 nanocrystals, then dispersed in 1ml chloroform;

[0029] c. Add 40mgPSI to 10mL0.5mM NaOH aqueous solution OAm and 1 mg hydrophobic Cu 7 S 4 Chloroform solution of nanocrystals, ultrasonic (500W, 6 minutes);

[0030] d. Stir at 60°C for 2h and distill off the chloroform. Centrifuge (12000 rpm) for 10 minutes to obtain hydrophilic nanocrystals and rod-shaped photothermally treated nanomaterials, which are redispersed in 2 ml of deionized water.

Embodiment 3

[0032]a. Mix 6ml of oleylamine (OAM), 4ml of octadecene (ODE), 75mg of thioacetamide (TA) and 0.4ml of dodecanethiol (DDT) and stir slowly, and inject 15mg of Cu(S 2 CNBut 2 ) precursor, kept at 190°C for 60min.

[0033] b. After the reaction is naturally cooled, take out the reaction solution and centrifuge (15000 rpm) for 10min to obtain hydrophobic Cu 7 S 4 nanocrystals, then dispersed in 1ml chloroform;

[0034] c. Add 30mgPSI to 10mL0.5mM NaOH aqueous solution OAm and 2 mg of hydrophobic Cu 7 S 4 Chloroform solution of nanocrystals, ultrasonic (500W, 6 minutes);

[0035] d. Stir at 60° C. for 2 hours to distill off the chloroform, centrifuge (12000 rpm) for 10 minutes to obtain hydrophilic nanocrystals, and obtain superlattice photothermally treated nanomaterials, which are redispersed in 2 ml of deionized water.

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Abstract

The invention discloses a nanometer material applicable to photothermal therapy and a preparation method thereof. The material designed by the invention has extremely-high photothermal conversion efficiency. According to the invention, hydrophobic Cu7S4 nanocrystalline is obtained by thermal decomposition of a single precursor; and on the premise that the original structure of the material is maintained, the surface properties of the material are changed by coating of an amphiphilic polymer, and the material is converted into an aqueous phase so as to obtain a monodisperse flake-assembly nanometer material, a monodisperse rod-assembly nanometer material and a nanometer superlattice nanometer material are obtained. Under same conditions, photothermal conversion efficiencies of the monodisperse flake-assembly and monodisperse rod-assembly Cu7S4 nanometer particles are 48.62% and 56.32%, respectively; while the photothermal conversion efficiency of the Cu7S4 nanometer superlattice is strongest and stable under irradiation of near-infrared light with a wavelength of 808 nm, reaching 65.7%. The application of the nanometer material in in-vitro photothermal therapy of cancer cells shows that the nanometer material provided by the invention is expected to be a medicament of photothermal therapy, so widespread concerns can be caused in the fields of material science, nanometer science, biological medicine, etc.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanometer materials, in particular to a kind of Cu with extremely high light-to-heat conversion efficiency 7 S 4 Nano superlattice can be applied in photothermal therapy. technical background [0002] Since photothermal ablation based on near-infrared nanomaterials is considered to be a non-invasive, pollution-free, and efficient cancer therapy, the design, synthesis, and assembly of near-infrared photothermal nanomaterials have attracted extensive attention. So far, in order to improve the photothermal conversion efficiency and enhance the thermal lethality to subcutaneous tumors, a large number of photothermal agents with near-infrared light intensity absorption have been explored. Several nanostructures, including gold nanoshells, gold nanorods, gold nanocages, layered gold nanoparticles, and hollow gold nanospheres, have been investigated for near-infrared photothermal therapy. Altho...

Claims

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Application Information

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IPC IPC(8): C01G3/12B82Y30/00
CPCC01G3/12C01P2002/82C01P2004/03
Inventor 汪乐余崔家斌
Owner BEIJING UNIV OF CHEM TECH
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