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Application of vitexin in preparation of medicine for treating postoperative pain

A vitexin and drug technology, applied in the field of medicine, can solve the problems of large adverse reactions, addiction, and low efficacy of therapeutic drugs, and achieve the effects of no sedative side effects and postoperative pain relief.

Active Publication Date: 2017-11-07
苏州康纯医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the current problems of insufficient treatment of postoperative pain, low effectiveness of therapeutic drugs, large adverse reactions or tolerance and addiction, the present invention provides a new clinical application of vitexin, specifically in the preparation of Application of drugs in the treatment of postoperative pain

Method used

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  • Application of vitexin in preparation of medicine for treating postoperative pain
  • Application of vitexin in preparation of medicine for treating postoperative pain
  • Application of vitexin in preparation of medicine for treating postoperative pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Establishment of mouse incision pain model

[0030] test methods:

[0031] The establishment method of mouse incision pain model refers to (Pogatzki EM, Raja SN.A mouse model of incisional pain [J]. Anesthesiology, 2003, 99 (4): 1023-27. Sahbaie P, Sun Y, Liang DYet al. Curcumin treatment attenuates pain and enhances functional recovery after incision [J]. Anesth Analg, 2014, 118(6): 1336-44.), the specific establishment method: using an anesthesia machine, mice are anesthetized with 3% isoflurane, and put on anesthesia Face mask, maintain anesthesia with 1.5% isoflurane, and fix in supine position. After the right hind foot of the mouse is sterilized with 75% alcohol, cut the skin with a No. 11 scalpel blade from 0.2 cm close to the heel to the direction of the toe, and make a 0.5 A cm-long longitudinal incision was made to pick out the fascia and cut it longitudinally in the center of the fascia. After hemostasis by light pressure, a stitch was sutured at ...

Embodiment 2

[0034] Example 2 Vitexin sedative effect experiment

[0035] Autonomic activity test method refers to (Zhu Q, Sun, YH; Yun XD et al. Antinociceptive effects of curcumin in a rat model of postoperative pain, Scientific Reports, 2014, 4:4932), specifically: use a tester for autonomic activity in rats and mice (YLS-1B, Jinan Yanyi Science and Technology Co., Ltd., China), the instrument contains a control unit and 4 cylindrical black plastic dark boxes (diameter 30cm, height 30cm), the mouse is put into the black plastic dark, and the light sensor is located in the box The center of the lid is used to record the number of voluntary activities of mice. The number of spontaneous activities of mice within 60 min was recorded.

[0036] Animal grouping: 48 male ICR mice; divided into 4 groups, namely the normal control group and vitexin 3mg / kg, 10mg / kg, 20mg / kg three dose groups, 12 in each group. The normal control group was given normal saline, and the remaining groups were inject...

Embodiment 3

[0039] Example 3 Effect of Acute Administration of Vitexin 1-10 mg / kg on Mechanical Pain Threshold of Incision Pain Model Mice

[0040] Grouping of animals: 60 ICR mice, divided into 5 groups; 12 in the vehicle group (given 0.5% CMC-Na); 12 vitexin 1, 3, 5.5, 10 mg / kg dose groups, 12 in each group (Note: administered by intraperitoneal injection, vitexin is configured by 0.5% CMC-Na).

[0041] All mice in each group underwent incision surgery, and the operation method was the same as above. The baseline value of PWT in each group was tested 24 hours after the operation (no drug was administered at this time). After administration, the PWT was tested every 30 minutes until the pain threshold returned to the postoperative baseline value. The method of measuring the pain threshold is the same as above. The result is as image 3 As shown, 24h after operation, the baseline value of mechanical pain threshold (expressed as 0min) was measured before administration, and then the mec...

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Abstract

The invention relates to the technical field of medicine, in particular to the application of vitexin in the preparation of medicine for treating postoperative pain. The pharmaceutical preparation of the present invention is usually used by intraperitoneal injection, and of course other administration methods can also be adopted: the acute (single) administration dosage after modeling is 1-10 mg / kg, and the chronic (repeated multiple times) administration dosage 3 ~ 10mg / kg. Both acute administration and chronic administration of the pharmaceutical preparation of the present invention can effectively relieve postoperative pain, have no sedative side effects, and do not observe tolerance and addiction.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of vitexin in the preparation of medicine for treating postoperative pain. Background technique [0002] Pain is an unpleasant sensory and emotional experience associated with tissue damage or potential tissue damage. According to the priority of onset and the duration of the disease, it can be classified into acute pain and chronic pain. Postoperative pain belongs to acute pain (the course of disease is generally less than 6 weeks), and it is a complex physiological response of the body to the disease itself and tissue damage caused by surgery (Zhang Chuanhan. Guidelines for Clinical Pain Treatment [M]. Beijing: China Medical Science and Technology Press, 2008: 502). At present, postoperative pain is a difficult clinical problem. If acute postoperative pain is not handled properly, it will lead to a series of adverse consequences, such as chronic pain, increas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P29/00
Inventor 李俊旭朱清毛丽娜刘成鹏孙越华
Owner 苏州康纯医药科技有限公司
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