Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation of polypyrrole/alginate gel with three-dimensional structure and electrical stimulation and pH response and dual controlled drug release

An alginate gel, three-dimensional structure technology, which is applied in the fields of material synthesis and biomedicine, can solve problems such as limited application, and achieves the effect of simple and easy preparation method and delayed release.

Active Publication Date: 2017-10-20
CHANGZHOU UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure alginate showed little response to electrical stimulation under electric field conditions
This reason limits its application in the field of electrochemistry, especially in the release of drugs by electrical stimulation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation of polypyrrole/alginate gel with three-dimensional structure and electrical stimulation and pH response and dual controlled drug release
  • Preparation of polypyrrole/alginate gel with three-dimensional structure and electrical stimulation and pH response and dual controlled drug release
  • Preparation of polypyrrole/alginate gel with three-dimensional structure and electrical stimulation and pH response and dual controlled drug release

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of salicylic acid-doped polypyrrole nanoparticles / alginate hydrogel includes the following steps:

[0023] (1) Prepare 5 mL of an aqueous solution of 10 mmol / L salicylic acid, weigh 70 mg of sodium dodecylbenzene sulfonate, add it to the above solution and stir to dissolve. Pipette 0.4 mL of a mixed solution of pyrrole and cyclohexane (volume ratio 1:3) and add it dropwise to the above solution, place in an ice bath and magnetically stir for 1.5 h. After the reaction, the solution was ultrasonically treated for 5 min to form a microemulsion. Add 10% polyvinyl alcohol solution, stir evenly and place in ice bath. Add 10 mL of 0.15 mol / L ammonium persulfate aqueous solution dropwise to the microemulsion, and ice-bath for 24 h. After centrifugation and washing for 5 times, freeze-drying was carried out for 24 hours to obtain salicylic acid-doped polypyrrole nanoparticles. Its scanning electron microscope picture is as figure 1 As shown, the polypyrrole n...

Embodiment 2

[0026] The in vitro release behavior of drugs under different potential conditions includes the following steps:

[0027] The preparation process of the salicylic acid-doped polypyrrole nanoparticle / alginate hydrogel is the same as that of Example 1.

[0028] (1) Prepare 0.1mol / L phosphate buffer solution (PBS, containing 0.15mol / L NaCl, pH 7.4) for simulating human environment, take 15mg of composite material, place it in a dialysis bag, and suspend the dialysis bag in 50mL Magnetic stirring was performed at a speed of 100 rpm in PBS, and electrical stimulation release was performed at 37°C. Drug release from the composite was performed using two stainless steel plates as conditions for applying an electric field. Adjust the electric field strength to 0V, 0.2V, 0.4V and 0.6V, release for 11.5h respectively;

[0029] (2) Draw 3mL of solution from the solution every 0.5h, measure the content of salicylic acid, and supplement the same volume of PBS at the same time. The conte...

Embodiment 3

[0031] The in vitro release behavior of drugs under different pH conditions includes the following steps;

[0032] The preparation process of the salicylic acid-doped polypyrrole nanoparticle / alginate hydrogel is the same as that of Example 1.

[0033](1) Prepare 0.1mol / L phosphate buffered saline solution (PBS, containing 0.15mol / L NaCl) for simulating the human body environment, take 15mg of the composite material, place it in a dialysis bag, and suspend the dialysis bag in 50mL of PBS Magnetic stirring was performed at a speed of 100 rpm, and electrical stimulation release was performed at 37°C. Adjust the pH of PBS to 3.4, 5.4, 7.4 and 9.4, release 11.5h respectively;

[0034] (2) Draw 3mL of solution from the solution every 0.5h, measure the content of salicylic acid, and supplement the same volume of PBS at the same time. The content of salicylic acid is measured at 298nm using ultraviolet spectrophotometry, and the cumulative drug release percentage at different times...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The present invention relates to the preparation of a polypyrrole / alginate gel with three-dimensional structure and electrical stimulation and pH response and its application to dual control drug release. The method comprises the following steps: preparing salicylic acid-doped polypyrrole nano Particles, preparation of salicylic acid-doped polypyrrole nanoparticles / alginate hydrogel and its application to dual controlled drug release. The beneficial effects of the present invention are: the polypyrrole / alginate hydrogel with a three-dimensional structure has electrical stimulation sensitivity and pH-responsive drug release behavior, can double control the release of drugs, and the preparation method of the material is simple and easy, and its delay It improves the release of the drug and keeps the drug effect in the body for a long time.

Description

technical field [0001] The invention relates to the preparation of a polypyrrole / alginate gel with three-dimensional structure and electric stimulation and pH response and its application to dual control drug release, belonging to the fields of material synthesis and biomedicine. technical background [0002] Smart drug release systems with stimuli-responsive features have attracted great interest in the past decades. To a certain extent, the intelligent drug sustained release system reduces the possible adverse reactions of drugs and improves the stability and effective utilization of drugs. There are many kinds of external stimuli that can trigger it to release drugs, including: electric field, magnetic field, pH value, light, heat, etc. In the study of drug sustained-release materials, pH-sensitive alginate is widely used in drug sustained-release systems that respond to pH. [0003] Alginate is a biocompatible and non-toxic natural polysaccharide extracted from seaweed...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L79/04C08L5/04C08K5/13A61K47/34A61K47/36A61K9/06A61K31/60A61P29/00A61P7/02
Inventor 孔泳葛寒砺邓林红潘艳
Owner CHANGZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com