Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal composition for treating kidney diseases and pharmaceutical application thereof

A kidney disease, composition technology, applied in the field of medicine, can solve problems such as not seen

Inactive Publication Date: 2015-11-04
XIAN SHIJISHENGKANG PHARMA IND
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, at present, there is no combination of rhubarb total anthraquinones containing emodin and / or rhein, astragalus polysaccharides and / or astragaloside IV, salvianolic acid or safflower glycosides in combination with a fixed dosage. There are no reports on the treatment of kidney and other diseases, and there are no reports containing chrysophanol and emodin methyl ether or actcoisoflavones, actcoisoflavone glycosides, etc. for the treatment of kidney diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition for treating kidney diseases and pharmaceutical application thereof
  • Medicinal composition for treating kidney diseases and pharmaceutical application thereof
  • Medicinal composition for treating kidney diseases and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0164] Take 2.5g of rhubarb total anthraquinones, 4g of astragalus extract, 2.6g of salvianolic acid, add PEG-20050ml, add water for injection to dilute to 500ml, filter, add water for injection to 800ml, adjust the pH value to 6.5-7.0, Add water for injection and dilute to 1000ml, filter through a 0.22μm microporous membrane, subpackage, and sterilize to obtain an injection.

Embodiment 2

[0166] Take 2.5g of rhubarb total anthraquinones, 4g of astragalus extract, 2.5g of safflower glycosides, add PEG-20050ml, add water for injection to dilute to 500ml, filter, add water for injection to 800ml, adjust the pH value to 6.5-7.0, add Dilute it with water for injection to 1000ml, filter through a 0.22μm microporous membrane, subpackage, and sterilize to obtain an injection.

Embodiment 3

[0168] Take 250g of rhubarb total anthraquinones, 230g of astragalus extract, 260g of salvianolic acid, appropriate amount of meglumine and arginine, add water for injection and dilute to 5L, stir until dissolved, filter, adjust the pH value of the filtrate to 5.0-7.0, Use a 0.22μm microporous membrane for fine filtration; take an appropriate amount of mannitol and add water for injection to prepare a solution, mix with the above filtrate, filter through a 0.22μm microporous membrane, add water for injection to dilute to 10L, and prepare 10ml of the unit preparation Packing in doses, freeze-drying to obtain freeze-dried powder.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a composition for treating kidney diseases and pharmaceutical application thereof. The composition comprises total anthraquinone composed of 1,3,8-trihydroxy-6-methylanthraquinone and / or rhein (4.5-dihydroxy anthraquinone), an astragalus root extract composed of astragalus polysaccharide and / or astragaloside, and salvianolic acid or carthamin and is applied to treating the kidney diseases and other diseases in a constant reagent quantity. The composition can further comprise 1,8-Dihydroxy-3-methyl-anthraquinone and 1,8-dihydroxy-3-methoxy-6-methylanthraquinone emodin3-methyl ether or calycosin, wherein calycosin-7-glucoside, salvianolic acid B and hydroxysafflor yellow A treat the kidney diseases. The composition can be prepared into a preparation in the form of solid, liquid, gas or semisolid; based on a quantity of experiments, the composition can be used for treating chronic renal failure, nephrotic syndrome, cardiovascular and cerebrovascular diseases, tumorous diseases and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating kidney diseases and its application. Background technique [0002] Rhein (Rhein, 4.5-dihydroxy anthraquinone) belongs to monoanthracene nucleus 1,8-dihydroxyanthraquinone derivatives, brown needle crystals, insoluble in water, soluble in pyridine, sodium bicarbonate aqueous solution, slightly soluble in ethanol, benzene , chloroform, ether and petroleum ether, molecular formula C15H8O6, mainly distributed in Polygonaceae plants, it is one of the main components of many traditional Chinese medicines such as rhubarb, Polygonum multiflorum, Polygonum cuspidatum, and leguminous, Scrophulariaceae plants also contain this component, It can also be obtained through artificial synthesis, and its drug source is abundant and easy to obtain. In recent years, studies have found that rhein has a wide range of pharmacological activities, such as li...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K36/537A61K31/715A61K31/7048A61P13/12A61P35/00A61P9/00A61P9/10A61P1/16
Inventor 吴芳吕延英王光建赵兴詹芳王俊平贾诚曾艳龙
Owner XIAN SHIJISHENGKANG PHARMA IND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com