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Preparation method for temperature-sensitive sol

A sol and temperature-sensitive technology, which is applied to non-active ingredients in medical preparations, pharmaceutical formulas, diseases, etc., to achieve remarkable therapeutic effects, easy preparation and operation, and good fluidity

Active Publication Date: 2015-10-21
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no patent documents and news reports about the application of chitosan / carboxymethyl chitosan / glycerophosphate system in the treatment field of gynecological inflammation such as vaginitis. The preparation method of the thermosensitive sol has great medical value and application prospect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation method of the temperature-sensitive sol involved in this embodiment comprises four steps: preparation of chitosan acetic acid solution, preparation of carboxymethyl chitosan aqueous solution, preparation of β-sodium glycerophosphate aqueous solution and preparation of temperature-sensitive sol:

[0016] (1), preparation of chitosan acetic acid solution: at normal temperature, 0.2g chitosan powder is dissolved in the acetic acid solution that volume is 4.5ml, concentration is 0.2Mol / L, obtains the chitosan that mass percentage concentration is 4.4% Acetic acid solution;

[0017] (2), preparation of carboxymethyl chitosan aqueous solution: at normal temperature, 0.2g carboxymethyl chitosan powder is dissolved in 4.5ml ultrapure water, obtains the carboxymethyl chitosan aqueous solution that mass percent concentration is 4.4% ;

[0018] (3) Preparation of β-sodium glycerophosphate aqueous solution: Dissolve 0.78g of β-sodium glycerophosphate powder in 1ml ...

Embodiment 2

[0024] The preparation method of the temperature-sensitive sol involved in this embodiment comprises four steps: preparation of chitosan acetic acid solution, preparation of carboxymethyl chitosan aqueous solution, preparation of β-sodium glycerophosphate aqueous solution and preparation of temperature-sensitive sol:

[0025] (1), chitosan acetic acid solution preparation: at normal temperature, 0.1g chitosan powder is dissolved in the acetic acid solution of 4.5ml, 0.2Mol / L, obtains the chitosan acetic acid solution that mass percent concentration is 2.2%;

[0026] (2), preparation of carboxymethyl chitosan aqueous solution: at normal temperature, 0.1g carboxymethyl chitosan powder is dissolved in 4.5ml ultrapure water, obtains the carboxymethyl chitosan aqueous solution that mass percent concentration is 2.2% ;

[0027] (3) Preparation of β-sodium glycerophosphate aqueous solution: Dissolve 0.8g of β-sodium glycerophosphate powder in 1ml of ultrapure water at a temperature o...

Embodiment 3

[0031] The preparation method of the temperature-sensitive sol involved in this embodiment comprises four steps: preparation of chitosan acetic acid solution, preparation of carboxymethyl chitosan aqueous solution, preparation of β-sodium glycerophosphate aqueous solution and preparation of temperature-sensitive sol:

[0032] (1), chitosan acetic acid solution preparation: at normal temperature, 0.3g chitosan powder is dissolved in the acetic acid solution of 4.5ml, 0.2Mol / L, obtains the chitosan acetic acid solution that mass percent concentration is 6.7%;

[0033] (2), preparation of carboxymethyl chitosan aqueous solution: at normal temperature, 0.3g carboxymethyl chitosan powder is dissolved in 4.5ml ultrapure water, obtains the carboxymethyl chitosan aqueous solution that mass percent concentration is 6.7% ;

[0034] (3) Preparation of β-sodium glycerophosphate aqueous solution: Dissolve 0.6g of β-sodium glycerophosphate powder in 1ml of ultrapure water at a temperature o...

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Abstract

The invention belongs to the technical field of medical drug manufacturing and particularly relates to a preparation method for temperature-sensitive sol used for treatment of gynecologic inflammation. The preparation method for the temperature-sensitive sol comprises four steps including preparation of a chitosan acetic acid solution, preparation of a carboxymethyl chitosan aqueous solution, preparation of a sodium beta-glycerophospahe aqueous solution and preparation of the temperature-sensitive sol, wherein chitosan powder is dissolved in an acetic acid solution, carboxymethyl chitosan powder is dissolved in ultrapure water, sodium beta-glycerophospahe powder is dissolved in the ultrapure water, then the chitosan acetic acid solution, the carboxymethyl chitosan aqueous solution and the sodium beta-glycerophospahe aqueous solution are obtained, finally the sodium beta-glycerophospahe aqueous solution is dropwise added into the carboxymethyl chitosan aqueous solution, after the mixture is stirred to be uniform, the uniformly-mixed mixture is added into the chitosan acetic acid solution, the obtained mixture is stirred again to be uniform, and then the temperature-sensitive sol is obtained. The preparation method for the temperature-sensitive sol has the advantages that the principle is scientific and reliable, the preparation operation is simple and convenient, the treatment effect is remarkable, the disadvantage that similar products can only be dosed at night is overcome, and the application prospect is wide.

Description

Technical field: [0001] The invention belongs to the technical field of medical drug manufacturing, and in particular relates to a method for preparing a temperature-sensitive sol. When used, the prepared temperature-sensitive sol is loaded with drugs and mixed into a gel for treating gynecological inflammations such as vaginitis. Background technique: [0002] The temperature-sensitive in-situ gel drug delivery system refers to that after the drug is administered with a liquid, it is stimulated by a temperature change (body temperature 37°C) at the medicinal site, and the liquid drug solidifies to form a gel, thereby controlling the release of the drug. It is widely used in Eye administration, nasal cavity administration and local injection administration, etc. can effectively reduce drug loss, prolong drug action time, and greatly improve drug bioavailability. site adverse reactions; studies have found that chitosan / carboxymethyl chitosan / glycerophosphate system sol has te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/24A61P15/02A61P15/00
Inventor 徐文华孔晓颖梁晔
Owner QINGDAO UNIV
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