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Zangfukang vaginal expansive suppository as well as preparation method and detection method thereof

A vaginal expansible suppository and detection method technology, applied in suppository delivery, pharmaceutical formulations, material inspection products, etc., can solve the problems of poor drug stability, difficult to clean, easy to contaminate clothes, etc., achieve fast drug release and overcome peak-valley phenomenon , to avoid the effect of secondary infection

Inactive Publication Date: 2015-10-14
HARBIN OT PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are not many studies on Zangfukang suppository in the prior art. Based on the technical problems of Zangfukang suppository in the prior art, after the traditional Chinese medicine raw material is mixed with the matrix, the drug stability is poor, the active ingredient is not dissolved well, and the activity The ingredients cannot be evenly coated on the vaginal mucosa; in addition, the tampon in the traditional Zangfukang suppository has no swelling effect, or the swelling is disordered, which greatly reduces the clinical application; it is not easy to clean and easily contaminates clothes; quality control methods Unreliable, leading to technical problems such as large variations in batch-to-batch content, stability, and melting time limit in the actual production process

Method used

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  • Zangfukang vaginal expansive suppository as well as preparation method and detection method thereof
  • Zangfukang vaginal expansive suppository as well as preparation method and detection method thereof
  • Zangfukang vaginal expansive suppository as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092]

[0093] Preparation:

[0094] 1) Preparation of drug-containing matrix:

[0095] a. heating and melting semi-synthetic fatty acid glycerides, anise fat and cocoa butter in a water bath to obtain a melt;

[0096] b. the preparation of Chinese medicine composition:

[0097] a) Weigh the Zanthoxylum bungeanum, Oxytropis chinensis, beech leaves and Basilicum chrysanthemum of prescription quantity, pulverize, add 70% ethanol after soaking for 2h, then use 70% ethanol to reflux and extract twice, the amount of adding ethanol for the first time is the total amount of the raw material drug. 10 times the amount, reflux for 2 hours, add ethanol for the second time to 3 times the total weight of the raw material drug, reflux for 1.5 hours, filter, combine the filtrates, recover ethanol, concentrate to a temperature of 60-70 ° C and a relative density of 1.30-1.32 Thick paste, spray-dried to obtain fine powder;

[0098] b) Weigh the prescription amount of horse urine foam, A...

Embodiment 2

[0103]

[0104] Preparation:

[0105] 1) Preparation of drug-containing matrix:

[0106] a. Polyethylene glycol 400 and polyethylene glycol 6000 are heated and melted in a water bath to obtain a melt;

[0107] b. the preparation of Chinese medicine composition:

[0108] a) Weigh the Zanthoxylum bungeanum and Oxytropis in the prescribed amount, crush them, add 70% ethanol to soak for 2 hours, then use 70% ethanol to reflux and extract twice, the amount of ethanol added for the first time is 10 times of the total amount of raw materials, and reflux for 2 hours, The amount of ethanol added for the second time is 3 times of the total weight of the crude drug, refluxed for 1.5h, filtered, combined filtrates, recovered ethanol, concentrated to a thick paste with a temperature of 60-70°C and a relative density of 1.30-1.32, spray-dried to obtain fine pink;

[0109] b) Weigh the prescribed amount of horse urine foam and crush it, add water to decoct twice, add water for the firs...

Embodiment 3

[0115]

[0116] Preparation method: Prepare 100 rod-shaped suppositories according to the method in Example 2, each weighing about 3.2g.

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Abstract

The invention relates to a Zangfukang vaginal expansive suppository as well as a preparation method and a detection method thereof. The expansive suppository comprises a medicine-containing base material formed by traditional Chinese medicine extract and a base material body, and an expansive carrier capable of expanding; the traditional Chinese medicine extract is mainly prepared from radix przewalskiae tanguticae, prickly ash peel, whin, artemisia dubia, caudate sweetleaf leaf, saussurea japonica and azalea; moreover, the medicine-containing base material also comprises sodium tripolyphosphate, crosslinked esterified tapioca modified starch, ethylene-vinyl acetate copolymer, lauric isopropanolamide and corn glue. The expansive suppository has the beneficial effects of being high in stability, good in dissolution of active ingredients, and high in bioavailability; moreover, the provided Xiaobiling vaginal expansive suppository adopts six original leading techniques, and the beneficial effects of preventing liquid medicine from flowing outwards, being quick in effect, preventing secondary infection and the like are realized.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Zangfukang vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] Zangfukang Suppository is modified according to the clinical experience of hospitals in the Tibet Autonomous Region. It is mainly composed of 7 kinds of Tibetan medicines such as horse urine foam, pepper and thorn bean. , Bacterial vaginosis and fungal vaginitis. There are not many studies on Zangfukang suppository in the prior art. Based on the technical problems of Zangfukang suppository in the prior art, after the traditional Chinese medicine raw material is mixed with the matrix, the drug stability is poor, the active ingredient is not dissolved well, and the activity The ingredients cannot be evenly coated on the vaginal mucosa; in addition, the tampon in the traditional Zangfukang suppository has no swelling effect, or the swelling is disorder...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/02A61K47/44A61K47/36A61K47/34G01N33/15G01N5/04A61P15/02A61P31/04A61P31/10
Inventor 邱学良邱明世
Owner HARBIN OT PHARMA
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