Cryptotanshinone skin cutin liposomal preparation and preparing method thereof

A technology of cryptotanshinone and keratin, which is applied in the field of pharmaceutical preparations, can solve the problems of inducing liver drug enzymes, easy decomposition when exposed to light, and poor water solubility, and achieve the effects of improving local bioavailability, improving poor water solubility, and reducing side effects

Active Publication Date: 2015-10-07
台山市力丰投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the research process of cryptotanshinone, some of its gradually emerging characteristics greatly limited its application in product formulations, such as poor water solubility, easy decomposition when exposed to light, and inducing effect on liver drug enzymes, etc.

Method used

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  • Cryptotanshinone skin cutin liposomal preparation and preparing method thereof
  • Cryptotanshinone skin cutin liposomal preparation and preparing method thereof
  • Cryptotanshinone skin cutin liposomal preparation and preparing method thereof

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preparation example Construction

[0022] The invention relates to a preparation method of cryptotanshinone skin cutin lipoid. The formula includes the following components in parts by weight: 0.5-7 parts of cryptotanshinone, 30-100 parts of ceramide, 20-125 parts of lecithin, and 10 parts of cholesterol ~200 parts, organic phase 800~5000 parts, water phase 2000~12500 parts. In the formula, cryptotanshinone is the main drug; lecithin and ceramide are used as film-forming materials, wherein lecithin is preferably selected from soybean lecithin, hydrogenated lecithin, egg yolk lecithin or a mixture of two kinds; cholesterol is a film stabilizer, regulating The fluidity of the membrane; the organic phase is selected from absolute ethanol or ether; the ceramide is water-soluble ceramide; the water phase can be selected from phosphate buffered saline or distilled water with different pH values ​​according to the properties of the drug.

[0023] The present invention mainly adopts the organic solvent injection method...

Embodiment 1

[0026] Dissolve 1.5 mg of cryptotanshinone, 0.1 g of soybean lecithin, and 0.025 g of cholesterol in 3 mL of absolute ethanol to obtain an organic phase; dissolve 0.03 g of ceramide in 10 mL of phosphate-buffered saline solution with a pH of 7.4 to obtain an aqueous phase, and place in a magnetic Preheat the stirrer to 50°C; maintain the temperature and maintain the magnetic stirring speed at 600rpm, slowly drop the organic phase into the water phase with a syringe, keep stirring for 3 hours to volatilize the ethanol, and transfer it to a brown glass bottle for storage.

Embodiment 2

[0028] Dissolve 1.5 mg of cryptotanshinone, 0.1 g of soybean lecithin, and 0.025 g of cholesterol in 3 mL of absolute ethanol to obtain an organic phase; dissolve 0.03 g of ceramide in 10 mL of phosphate-buffered saline solution with a pH of 7.4 to obtain an aqueous phase, and place in a magnetic Preheat the stirrer to 50°C; maintain the temperature and maintain the magnetic stirring speed at 600rpm, slowly drop the organic phase into the water phase with a syringe, keep stirring for 3 hours to volatilize the ethanol, and transfer it to a brown glass bottle for storage.

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Abstract

The invention discloses a cryptotanshinone skin cutin liposomal preparation and a preparing method thereof. According to a formula, cryptotanshinone, lectin and cholesterol are dissolved in an organic phase, ceramide is dissolved in a water phase, preheating is allowed on a magnetic stirrer, the obtained organic phase is slowly dropped into the water phase, in which the ceramide is dissolved during magnetic stirring, and continuous stirring is performed to volatize the organic phase and transferred to a brown glass bottle for preservation. The cryptotanshinone skin cutin liposomal preparation has the advantages that the speed of the cryptotanshinone to permeate the skin can be evidently increased, and quantity of the preparation enters general circulation can be decreased at the premise of improving local effect; by preparation by means of organic solvent injection, the problems such that the cryptotanshinone is poor in water solubility and unstable are evidently improved, the speed of the cryptotanshinone to permeate through the cuticle can be increased, and a higher quantity of the preparation retains on the skin; the preparation can be prepared into various transdermal drugs, such as gels, ointments and plasters; the preparation is more widely applicable in the field of pharmaceuticals and cosmetics.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a novel drug carrier cryptotanshinone skin cutin lipoid preparation and a preparation method thereof. Background technique: [0002] Cryptotanshinone (CTS) is a very representative component of the fat-soluble components of Salvia miltiorrhiza in the Lamiaceae plant. In terms of topical treatment of skin diseases, it has shown strong activity in improving microcirculation, subsiding inflammation, and repairing skin lesions. At present, the topical patent medicines containing cryptotanshinone on the market are mainly used to treat acne, such as tanshinone ointment, gramacinone ointment, gramacinone gel, etc. Clinically, the Danshen preparation with cryptotanshinone as the active ingredient is effective in treating inflammatory and pustular acne, and animal experiments show that it is non-toxic and non-irritating. The chemical constituents of the total tanshinone separa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K8/02A61K31/58A61K47/12A61K8/49A61K8/42A61P17/10A61Q19/00
Inventor 刘强左婷朱红霞陈活计翁立冬乡世健洪军辉曹思玮
Owner 台山市力丰投资有限公司
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