A kind of cryptotanshinone skin keratin liposome preparation and its preparation method

A technology of cryptotanshinone and keratin, which is applied in the field of pharmaceutical preparations, can solve the problems of inducing liver drug enzymes, easy decomposition when exposed to light, and poor water solubility, and achieve the effects of improving local bioavailability, improving poor water solubility, and reducing side effects

Active Publication Date: 2018-12-04
台山市力丰投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the research process of cryptotanshinone, some of its gradually emerging characteristics greatly limited its application in product formulations, such as poor water solubility, easy decomposition when exposed to light, and inducing effect on liver drug enzymes, etc.

Method used

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  • A kind of cryptotanshinone skin keratin liposome preparation and its preparation method
  • A kind of cryptotanshinone skin keratin liposome preparation and its preparation method
  • A kind of cryptotanshinone skin keratin liposome preparation and its preparation method

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preparation example Construction

[0022] The present invention is a preparation method of cryptotanshinone skin keratinoid body. Calculated by weight, the formula includes the following components: 0.5-7 parts of cryptotanshinone, 30-100 parts of ceramide, 20-125 parts of lecithin, and 10 parts of cholesterol. ~200 parts, organic phase 800-5000 parts, aqueous phase 2000-12500 parts. In the formula, cryptotanshinone is the main drug; lecithin and ceramide are used as film-forming materials, and the lecithin is preferably one or two mixtures of soybean lecithin, hydrogenated lecithin, and egg yolk lecithin; cholesterol is a membrane stabilizer, regulating The fluidity of the membrane; the organic phase is selected from absolute ethanol or diethyl ether; the ceramide is a water-soluble ceramide; the water phase can be selected from phosphate buffered saline solution or distilled water with different pH values ​​according to the properties of the drug.

[0023] The present invention mainly adopts an organic solven...

Embodiment 1

[0026] Dissolve 1.5 mg of cryptotanshinone, 0.1 g of soybean lecithin, and 0.025 g of cholesterol in 3 mL of absolute ethanol to obtain an organic phase; dissolve 0.03 g of ceramide in 10 mL of a phosphate buffered saline solution with pH 7.4 to obtain an aqueous phase, and place it in a magnetic Preheat to 50°C on the stirrer; keep the temperature, keep the magnetic stirring speed at 600rpm, slowly drop the organic phase into the water phase with a syringe, continue stirring for 3h to volatilize the ethanol, and transfer to a brown glass bottle for storage.

Embodiment 2

[0028] Dissolve 1.5 mg of cryptotanshinone, 0.1 g of soybean lecithin, and 0.025 g of cholesterol in 3 mL of absolute ethanol to obtain an organic phase; dissolve 0.03 g of ceramide in 10 mL of a phosphate buffered saline solution with pH 7.4 to obtain an aqueous phase, and place it in a magnetic Preheat to 50°C on the stirrer; keep the temperature, keep the magnetic stirring speed at 600rpm, slowly drop the organic phase into the water phase with a syringe, continue stirring for 3h to volatilize the ethanol, and transfer to a brown glass bottle for storage.

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Abstract

The invention discloses a cryptotanshinone skin cutin liposomal preparation and a preparing method thereof. According to a formula, cryptotanshinone, lectin and cholesterol are dissolved in an organic phase, ceramide is dissolved in a water phase, preheating is allowed on a magnetic stirrer, the obtained organic phase is slowly dropped into the water phase, in which the ceramide is dissolved during magnetic stirring, and continuous stirring is performed to volatize the organic phase and transferred to a brown glass bottle for preservation. The cryptotanshinone skin cutin liposomal preparation has the advantages that the speed of the cryptotanshinone to permeate the skin can be evidently increased, and quantity of the preparation enters general circulation can be decreased at the premise of improving local effect; by preparation by means of organic solvent injection, the problems such that the cryptotanshinone is poor in water solubility and unstable are evidently improved, the speed of the cryptotanshinone to permeate through the cuticle can be increased, and a higher quantity of the preparation retains on the skin; the preparation can be prepared into various transdermal drugs, such as gels, ointments and plasters; the preparation is more widely applicable in the field of pharmaceuticals and cosmetics.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a novel pharmaceutical carrier cryptotanshinone skin keratinoid liposome preparation and a preparation method thereof. Background technique: [0002] Cryptotanshinone (CTS) is a highly representative component of the lipid-soluble components of Salvia miltiorrhiza. In the topical treatment of skin diseases, it has shown strong activity in improving microcirculation, reducing inflammation, and repairing skin lesions. At present, the topical medicines containing cryptotanshinone on the market are mainly used for the treatment of acne, such as tanshinone ointment, Kecuocryptone ointment, and Kecuocryptone gel. Clinically, the Danshen preparation with cryptotanshinone as the active ingredient has significant effect in the treatment of inflammatory and pustular acne, and animal experiments show that it is non-toxic and non-irritating. The isolated chemical components of to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K8/02A61K31/58A61K47/12A61K8/49A61K8/42A61P17/10A61Q19/00
Inventor 刘强左婷朱红霞陈活计翁立冬乡世健洪军辉曹思玮
Owner 台山市力丰投资有限公司
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