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Sucrose sulfate copper and silver compound as well as preparation method and application thereof

A production method and sulfuric acid ester technology, applied in the medical field, can solve problems such as the induction of drug-resistant strains, toxic and side effects, and clinical treatment problems, and achieve broad-spectrum antibacterial activity, high-efficiency antibacterial and anti-inflammatory effects, and promote the healing of wounds and burns

Inactive Publication Date: 2015-09-23
GUANGXI TEACHERS EDUCATION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term large-scale use of antibiotics and antibacterial drugs will produce systemic toxic and side effects, such as long-term external use of gentamicin, which will cause ototoxicity and nephrotoxicity; Antibacterial drugs are ineffective and will cause new problems for clinical treatment
Sulfonamides are broad-spectrum antimicrobials, but because many common clinical pathogens are resistant to such drugs, they are only used for infections caused by sensitive bacteria and other sensitive pathogenic microorganisms

Method used

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  • Sucrose sulfate copper and silver compound as well as preparation method and application thereof
  • Sucrose sulfate copper and silver compound as well as preparation method and application thereof
  • Sucrose sulfate copper and silver compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A kind of sucrose sulfate ester copper-silver compound, its structural formula is (I):

[0039]

[0040] where R represents 1 / 2Cu.

[0041] The preparation method of described sucrose sulfate ester copper-silver compound comprises the following steps:

[0042] Step 1, the aqueous solution of sodium sucrose sulfate and double distilled water are eluted successively through the first strong acid type cation exchange resin, and the eluents are combined to obtain the aqueous solution of sucrose sulfate, and the structural formula (II) of sucrose sulfate is as follows;

[0043]

[0044] Step 2, the aqueous solution of sucrose sulfate obtained in step 1 and the double distilled water are passed successively through adsorption with Cu 2+ The second weak acid type cation exchange resin elution, combined eluent, obtains the aqueous solution of sucrose sulfate copper compound, and the structural formula (III) of sucrose sulfate copper compound is as follows;

[0045]

...

Embodiment 2

[0069] A kind of sucrose sulfate ester copper-silver compound, its structural formula is (I):

[0070]

[0071] where R represents 1 / 2Cu.

[0072] The preparation method of described sucrose sulfate ester copper-silver compound comprises the following steps:

[0073] Step 1, the aqueous solution of sodium sucrose sulfate and double distilled water are eluted successively through the first strong acid type cation exchange resin, and the eluents are combined to obtain the aqueous solution of sucrose sulfate, and the structural formula (II) of sucrose sulfate is as follows;

[0074]

[0075] Step 2, the aqueous solution of sucrose sulfate obtained in step 1 and the double distilled water are passed successively through adsorption with Cu 2+ The second weak acid type cation exchange resin elution, combined eluent, obtains the aqueous solution of sucrose sulfate copper compound, and the structural formula (III) of sucrose sulfate copper compound is as follows;

[0076]

...

Embodiment 3

[0100] A kind of sucrose sulfate ester copper-silver compound, its structural formula is (I):

[0101]

[0102] where R represents 1 / 2Cu.

[0103] The preparation method of described sucrose sulfate ester copper-silver compound comprises the following steps:

[0104] Step 1, the aqueous solution of sodium sucrose sulfate and double distilled water are eluted successively through the first strong acid type cation exchange resin, and the eluents are combined to obtain the aqueous solution of sucrose sulfate, and the structural formula (II) of sucrose sulfate is as follows;

[0105]

[0106] Step 2, the aqueous solution of sucrose sulfate obtained in step 1 and the double distilled water are passed successively through adsorption with Cu 2+ The second weak acid type cation exchange resin elution, combined eluent, obtains the aqueous solution of sucrose sulfate copper compound, and the structural formula (III) of sucrose sulfate copper compound is as follows;

[0107]

...

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Abstract

The invention discloses a sucrose sulfate copper and silver compound. The structural formula (I) of the sucrose sulfate copper and silver compound is as shown in the description, wherein R represents 1 / 2Cu, Ag or H; the number of 1 / 2Cu or Ag in the sucrose sulfate copper and silver compound is greater than 1. The invention also relates to a preparation method of the compound, a pharmaceutical composition taking the compound as an active component and application of the compound and the pharmaceutical composition in preparing medicines for treating burn wounds and other traumatic infections. The compound has efficient, broad-spectrum antibacterial activity. The pharmaceutical composition of the compound has efficient activity of resisting bacteria, diminishing inflammation and promoting healing of burn wounds.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to sucrose sulfate copper-silver compounds, a preparation method and application thereof. Background technique [0002] Copper and silver ions have a long history of being used as antibacterial disinfectants to sterilize bacteria. Silver-copper series antibacterial powder has killing and inhibiting effects on Escherichia coli, Staphylococcus aureus, cholera, hepatitis B virus, etc. Ag + 、Cu 2+ The active ingredient of Escherichia coli is mainly destroyed or hindered by the contact reaction, when a small amount of Ag + 、Cu 2+ When reaching the bacterial cell, the bacterial cell wall and cell membrane are negatively charged, relying on electrostatic attraction, the bacterial cell wall and cell membrane firmly adsorb Ag + 、Cu 2+ , Ag + 、Cu 2+ Penetrate the cell membrane into the cell, coagulate the protein, destroy the activity of bacterial cell synthetase, and cause the dissol...

Claims

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Application Information

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IPC IPC(8): C07H11/00C07H1/00A61K31/7024A61K31/7135A61P17/02A61P31/02
Inventor 黄燕敏杨雷崔建国甘春芳郑嘉桦刘志平
Owner GUANGXI TEACHERS EDUCATION UNIV
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