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Medicine for treating osteoporosis caused by liver-kidney yin deficiency and preparation method of medicine

A technology for osteoporosis and yin deficiency type, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc. It can solve the problems of ignorance of the impact of fracture incidence, unexplained etiological significance, and inappropriate joint application. Achieve good therapeutic effect, relieve pain, and not easy to relapse

Inactive Publication Date: 2015-09-16
吴强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Calcitonin (CT) deficiency: after menopause, the level of CT decreases, which may contribute to the occurrence of osteoporosis due to the weakening of factors that inhibit bone resorption
(4) The role of other hormones: some data show that patients with primary osteoporosis have abnormal secretion of thyroid hormones, glucocorticoids, growth hormones, life factors (especially growth interferon C), and gastrin, but their Etiological significance not clarified
2. The treatment of specific etiology should not be ignored, especially the overlapping existence of primary osteoporosis and secondary osteoporosis should not be ignored
6. It is not advisable to combine two or more bone resorption inhibitors. Bone resorption inhibitors include estrogen, estrogen receptor modulators, bisphosphonates, and calcitonin. One or more, and when applied in sufficient amount (for example: while adequate dose of female hormone replacement, application of alendronate sodium (Fosamax) 10 mg per day), although the increase of bone density is more effective, it is not yet known The impact on "bone microstructure", "bone fragility" and "fracture incidence"

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1 Decoction

[0073] Recipe: holly seeds 16g, pig liver 8g, sheep liver 7g, antlers 2g, medlar 12g, cloves 16g, Dipsacus 6g, Achyranthes bidentata 9g, Amomum 13g, Shayuanzi 17g, mulberry 18g, jujube kernel 13g, sea pine nuts 16g , walnut kernel 16g, egg ginseng 16g, ganoderma lucidum 8g, bamboo leek 12g, purple river car 5g, clam 7g, dog ridge 8g, sugar cane 16g, red cohosh 15g, rattan eucommia 8g, deer bit grass 15g, windproof 15g, oat grass 15g, Laojunxu 8g, Cowpea 15g, Tiger Ginger 3g, Jiaopanlan 16g, Turtle Meat 8g.

[0074] Its preparation method is:

[0075] Step 1: Mix the raw materials and medicinal materials into a purple casserole, add clear water until the clear water soaks 3 cm above the upper surface of the medicinal materials, and soak for 5 hours;

[0076] Step 2: Put the purple casserole pot on the fire, boil it with strong fire, then switch to slow fire for 30-50 minutes until the dosage of the liquid medicine is 200ml, filter to obtain the...

Embodiment 2

[0079] Example 2 Granules

[0080] Recipe: Holly 16g, pig liver 8g, sheep liver 7g, antler 1g, medlar 12g, clove 16g, Dipsacus 8g, Achyranthes bidentata 10g, Amomum 12g, Shayuanzi 16g, mulberry 16g, jujube kernel 15g, sea pine nut 16g , walnut kernel 16g, egg ginseng 18g, ganoderma lucidum 8g, bamboo leek 12g, purple river car 5g, cockles 6g, dog ridge 8g, sugar cane 16g, red cohosh 18g, eucommia vine 9g, deer bit grass 15g, windproof 16g, oat grass 18g, Laojunxu 9g, Cowpea 15g, Tiger Ginger 3g, Jiaopanlan 18g, Turtle Meat 8g.

[0081] Its preparation method is:

[0082] Step 1: Mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration of 80% that is 5 times that of the mixture, heat to boiling and reflux for 3 hours, filter, and use percolation method at a speed of 1ml per minute. Percolation, collect the percolation liquid, then concentrate under reduced pressure at 0.06Mpa to a paste with a relative density of 1.14 at 50°C, s...

Embodiment 3

[0084] Example 3 Capsules

[0085] Recipe: Holly Seed 19g, Pork Liver 8g, Lamb Liver 10g, Antler 2g, Lycium barbarum 12g, Clove 18g, Dipsacus 8g, Achyranthes bidentata 9g, Amomum 18g, Shayuanzi 18g, Mulberry 17g, Semen 16g, Pinus pilosulae 17g , walnut kernel 16g, egg ginseng 15g, ganoderma lucidum 8g, bamboo leek 12g, purple river car 6g, cockles 6g, dog ridge 8g, sugar cane 16g, red cohosh 16g, rattan ulmoides 12g, deer bit grass 17g, windproof 12g, oat grass 16g, Laojunxu 12g, cowpea 16g, tiger ginger 3g, horned orchid 16g, turtle meat 8g.

[0086] Its preparation method is:

[0087] In the first step, the holly seeds, pig liver, sheep liver, antlers and medlar are mixed according to the stated ratio, and the volatile oil is extracted by adding 3 times of water relative to the mixture, and the obtained volatile oil is clathrated with β-cyclodextrin, and the volatile oil is mixed with The ratio of β-cyclodextrin is 1:2, stirred for 80 minutes, and the temperature is 50°C t...

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PUM

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Abstract

The invention discloses a medicine for treating osteoporosis caused by liver-kidney yin deficiency and a preparation method of the medicine. The medicine comprises the following medicinal materials: purpleflower holly fruits, pork liver, lamb liver, deer horn, wolfberry fruit, clove, teasel root, radix achyranthis bidentatae, fructus amomi, flatstem milkvetch seed, mulberry, spina date seed, korean pine seed, walnut kernel, codonopsis convolvulacea, lucid ganoderma, bamboo juice, human placenta, bloody clam, rhizoma cibotii, sugarcane, astilbe chinensis, parabarium micranthum pierre, pyrola, divaricate saposhnikovia root, oat grass, unpleasant swallowwort herb, cowpea, tendrilleaf solomonseal rhizome, herminium monorchis and turtle meat. The medicine has the efficacies of tonifying the liver, benefiting the kidneys, benefiting qi, nourishing blood, strengthening tendons and bones, tonifying qi, strengthening exterior, nourishing yin and nourishing the kidneys, and is mainly used for treating osteoporosis caused by liver-kidney yin deficiency. The medicine is based on the theory of the traditional Chinese medicine, emphasizes the holistic view is stressed and has the function of relieving the problem of bones by adjusting the whole body; and the medicine is capable of restoring bone health, relieving pain, and improving the symptoms of osteoporosis, and is safe, effective, convenient to take, good in treatment effect, fast in acting, low in recurring rate and free of side effects.

Description

technical field [0001] The invention relates to a medical preparation containing raw materials derived from plants, animals or minerals, in particular to a medicine for treating liver and kidney yin deficiency type osteoporosis and a preparation method thereof. Background technique [0002] Osteoporosis is a systemic bone metabolic disease characterized by low bone mass and microarchitectural destruction of bone tissue, resulting in increased bone fragility and susceptibility to fracture. The disease is common in the elderly, but it can occur at any age. Osteoporosis can be divided into primary and secondary types. Primary osteoporosis refers to other diseases that do not cause the disease; secondary osteoporosis refers to the reduction of bone tissue due to various systemic or endocrine and metabolic diseases. In addition, according to the site of occurrence, it can also be divided into localized or generalized osteoporosis. [0003] Symptoms and signs: Osteoporosis wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P19/10A61K35/50A61K35/407A61K35/612A61K35/618
Inventor 石萍吴强
Owner 吴强
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