Celandine polysaccharide extracted from Chelidonium majus and application of celandine polysaccharide

The technology of celandine and polysaccharide is applied to celandine polysaccharide and its application field, which can solve the problem of no report on the extraction and separation of polysaccharide components, and the pharmacological activity has not been reported, and achieves the effects of enhancing immunity, simple method and wide source.

Inactive Publication Date: 2015-09-09
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on natural medicinal chemistry and pharmacology mainly focuses on the alkaloid components of celandine, but there is no report on the extraction, separation and pharmacological activity of its polysaccharide components.

Method used

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  • Celandine polysaccharide extracted from Chelidonium majus and application of celandine polysaccharide
  • Celandine polysaccharide extracted from Chelidonium majus and application of celandine polysaccharide
  • Celandine polysaccharide extracted from Chelidonium majus and application of celandine polysaccharide

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The extraction method of the celandine polysaccharide of the present embodiment comprises the following steps:

[0016] (1) Take celandine medicinal powder, add water 10 times the weight of celandine medicinal powder, extract twice at 60°C for 1 hour each time, filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.10 at 40°C, and obtain concentrated polysaccharides liquid;

[0017] (2) Add volume fraction 95% ethanol to the polysaccharide concentrated solution of step (1) until the alcohol content reaches 80%, let it stand overnight, take the bottom precipitate, and use dehydrated alcohol 50 times the weight of the precipitate successively for the gained precipitate , acetone, and anhydrous ether, each washed once, dried to obtain crude polysaccharide;

[0018] (3) Take 0.2 g of the crude polysaccharide of step (2) and dissolve it in 10 mL of water, put the sample on the HPD-600 type macroporous adsorption resin column, and elute ...

Embodiment 2

[0020] The extraction method of the celandine polysaccharide of the present embodiment comprises the following steps:

[0021] (1) Take celandine medicinal material powder, add water 40 times the weight of celandine medicinal material powder, extract 3 times at 100°C for 3 hours each time, filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.20 at 40°C, and obtain concentrated polysaccharides liquid;

[0022] (2) Add volume fraction 100% ethanol to the polysaccharide concentrate in step (1) until the alcohol content reaches 80%, let it stand overnight, take the bottom precipitate, and use dehydrated alcohol 100 times the weight of the precipitate successively for the gained precipitate , acetone, and anhydrous ether, each washed twice, and dried to obtain crude polysaccharide;

[0023] (3) Take 1.0 g of the crude polysaccharide of step (2) and dissolve it in 10 mL of water, load it on a HPD-600 type macroporous adsorption resin column, ...

Embodiment 3

[0025] The extraction method of the celandine polysaccharide of the present embodiment comprises the following steps:

[0026] (1) Take celandine medicinal powder, add water 25 times the weight of celandine medicinal powder, extract twice at 80°C for 2 hours each time, filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.15 at 40°C, and obtain concentrated polysaccharides liquid;

[0027] (2) Add volume fraction 98% ethanol to the polysaccharide concentrate in step (1) until the alcohol content reaches 80%, let it stand overnight, take the bottom precipitate, and use dehydrated alcohol 60 times the weight of the precipitate successively for the gained precipitate , acetone, and anhydrous ether, each washed once, dried to obtain crude polysaccharide;

[0028] (3) 0.5 g of the crude polysaccharide of step (2) was dissolved in 10 mL of water, loaded on a HPD-600 type macroporous adsorption resin column, and eluted with 250 mL of water at a...

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Abstract

The invention discloses celandine polysaccharide extracted from Chelidonium majus and application of celandine polysaccharide and aims to achieve effectiveness in extraction of celandine polysaccharide and applicability to medicines for improving immunity. The technical scheme includes that adding water to Chelidonium majus powder, extracting, filtering and carrying out vacuum concentration to obtain polysaccharide concentrated solution; adding ethanol for precipitation, washing to obtain crude polysaccharide, sampling resin columns, subjecting eluent to vacuum concentration, adding ethanol for precipitation and washing to obtain celandine polysaccharide. In a process of extraction of the celandine polysaccharide from Chelidonium majus, raw materials which are natural traditional Chinese medicinal materials are extensive in source and low in cost. The celandine polysaccharide is taupe powder and has an excellent function for improving body immunity, application of Chelidonium majus to preparation of healthcare foods and medicines for improvement of body immunity creates a new application prospect of Chelidonium majus, and high social benefits and economic benefits are achieved while innovations on traditional Chinese medicine are realized.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a celandine polysaccharide extracted from celandine and its application. Background technique [0002] In recent years, with the advancement of social science and technology, the improvement of living standards and the enhancement of public self-care awareness, more and more people are focusing on products that can enhance immunity, which greatly promotes the research on immune enhancement products. Plant polysaccharides are a class of ingredients extracted from natural medicines. Modern studies have shown that plant polysaccharides have activities such as improving human immunity, anti-tumor, anti-virus, anti-oxidation, anti-aging, lowering blood sugar, lowering blood fat, and healing ulcers. Moreover, many studies have shown that polysaccharides have strong biological activity and are the main active ingredients of natural medicines. [0003] Celandine is the dried whole herb of Chelid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61P37/02A23L1/09A23L1/30
Inventor 王彦志张杰刘炯刘富岗杨云
Owner HENAN UNIV OF CHINESE MEDICINE
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