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Method for preparing dimethyl succinate

A technology of dimethyl succinate and disodium succinate, applied in the direction of microorganism-based methods, biochemical equipment and methods, and carboxylate preparation, can solve the problem of low conversion rate of succinic acid and complicated preparation process And other issues

Inactive Publication Date: 2015-09-02
镇江博睿兴邦生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional preparation process involves processes such as succinic acid purification, catalyst cleaning, regeneration, and removal of deactivated catalysts. The preparation process is relatively complicated, and the conversion rate of succinic acid is not high.

Method used

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Examples

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Comparison scheme
Effect test

Embodiment 1

[0029] A method for preparing dimethyl succinate, its preparation method is as follows:

[0030] (1) Preparation of disodium succinate fermentation broth:

[0031] ① Weigh 5 kg of peptone, 20 kg of corn steep liquor, 20 kg of glucose, 1.5 kg of potassium dihydrogen phosphate, 1.5 kg of disodium hydrogen phosphate, 5 kg of yeast extract, and 947 kg of deionized water to form a seed medium with a total mass of 1000 kg, and put it in a fermentation kettle Use seed culture medium to cultivate Actinobacillus succinic acid, need to pass into carbon dioxide in the described fermenter, the per minute volume of carbon dioxide feeds 10L, flow and add 1mol / L sodium hydroxide in the fermentation process, the pH value of the system is stabilized at 7.0;

[0032] ② Weigh 50kg of peptone, 100kg of corn steep liquor, 1000kg of glucose, 25kg of potassium dihydrogen phosphate, 25kg of disodium hydrogen phosphate, 50kg of yeast extract, 50kg of sodium acetate, and 8700kg of deionized water to f...

Embodiment 2

[0042] A method for preparing dimethyl succinate, its preparation method is as follows:

[0043] (1) Preparation of the disodium succinate fermented liquid that mass concentration is 10% is prepared with the step of specific embodiment one:

[0044] (2) Treatment of disodium succinate fermentation broth

[0045] ① Use a plate and frame filter to filter the disodium succinate fermentation liquid to obtain the clear liquid stock solution. At this time, the protein content of the clear liquid stock liquid is 0.035%, and the total amount of heavy metal ions is 0.03%;

[0046] ②Add powdered activated carbon to the clear liquid stock solution obtained in step (2)①, remove the protein and pigment in the clear liquid stock solution to obtain the primary treatment clear liquid, add powdered activated carbon to account for 5% of the mass of the clear liquid stock solution, and process The temperature is 60 degrees, and the time is 30 minutes. At this time, the light transmittance of the ...

Embodiment 3

[0053] A method for preparing dimethyl succinate, its preparation method is as follows:

[0054] (1) Preparation of the disodium succinate fermented liquid that mass concentration is 10% is prepared with the step of specific embodiment one:

[0055] (2) Treatment of disodium succinate fermentation broth

[0056] ① Use a plate and frame filter to filter the disodium succinate fermentation liquid to obtain the clear liquid stock solution. At this time, the protein content of the clear liquid stock liquid is 0.035%, and the total amount of heavy metal ions is 0.03%;

[0057] ②Add powdered activated carbon to the clear liquid stock solution obtained in step (2)①, remove the protein and pigment in the clear liquid stock solution to obtain the primary treatment clear liquid, add powdered activated carbon to account for 3% of the mass of the clear liquid stock solution, and process The temperature is 60 degrees, and the time is 30 minutes. At this time, the light transmittance of th...

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Abstract

The invention relates to a method for preparing dimethyl succinate. The method comprises the following steps: (1) preparing disodium succinate fermented liquid; (2) treating the disodium succinate fermented liquid; and (3) preparing dimethyl succinate by using a bipolar-membrane electrodialysis apparatus. The processes such as catalyst cleaning, regeneration, and the removal of a deactivated catalyst, and the like existing in the traditional preparation process are omitted; and the whole reaction process is green and clean, and completely conforms to the operating requirements of the modern chemical industry.

Description

technical field [0001] The invention relates to a method for directly preparing dimethyl succinate without purification of succinic acid by using disodium succinate fermentation liquid, and the invention belongs to the technical field of biochemical industry. Background technique [0002] Succinic acid (succinic acid), also known as succinic acid, widely exists in organisms, is an important dibasic organic carboxylic acid, and is also an important metabolite of the microbial tricarboxylic acid cycle glycolysis pathway. At present, succinic acid can be prepared by microbial fermentation. [0003] The preparation of traditional succinates is completed by succinic acid and small molecular alcohols (methanol, ethanol, butanol, etc.) under the conditions of strong acid catalysts, high temperature and high pressure; strong acid catalysts include concentrated sulfuric acid, Liquid acids such as fluorosulfonic acid and oleum, and solid acids such as acidic cation exchange resins an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/62C07C69/40C07C67/08C12R1/01
CPCY02P20/584C12P7/62C07C67/08C07C69/40
Inventor 吕涛
Owner 镇江博睿兴邦生物科技有限公司
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