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Preparation method of medical hemostatic sponge material

A technology of hemostatic sponge and potassium alginate, which is applied in the field of preparation of medical hemostatic sponge materials, can solve the problems of insignificant hemostatic effect and poor toughness, and achieve the effects of eliminating hidden dangers of viruses, promoting recovery ability, and improving use safety

Inactive Publication Date: 2015-09-02
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, pure chitosan hemostatic materials have the problems of poor toughness and insignificant hemostatic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A kind of preparation method of medical hemostatic sponge material, its preparation method comprises the following steps:

[0017] (1) Weigh each component by weight ratio: 30 parts of hydroxypropyl chitin, 10 parts of modified chitosan, 3 parts of lemon peel pectin, 3 parts of potassium alginate, 5 parts of mupirocin, 3 parts of triglycerol monostearate, 3 parts of plastin, 25 parts of linolenic acid, 2 parts of ethylene glycol, 3 parts of mannose, 3 parts of antibacterial agent, 10 parts of porogen and 35 parts of deionized water.

[0018] (2) Place the above-mentioned weighed components in a stirrer for stirring, the stirring speed is 90-100rpm, and the stirring time is 80-90min;

[0019] (3) Pour the mixed solution obtained in step (2) into a film-forming device, and freeze-dry in a vacuum freeze dryer for 15h~35h to obtain an antibacterial and anti-inflammatory medical sponge.

[0020] The modified chitosan is a mixture of β-cyclodextrin grafted chitosan and carb...

Embodiment 2

[0025] A kind of preparation method of medical hemostatic sponge material, its preparation method comprises the following steps:

[0026] (1) Weigh each component by weight: 40 parts of hydroxypropyl chitin, 20 parts of modified chitosan, 10 parts of lemon peel pectin, 12 parts of potassium alginate, 11 parts of mupirocin, 5 parts of triglycerol monostearate, 8 parts of plastin, 35 parts of linolenic acid, 8 parts of ethylene glycol, 9 parts of mannose, 6 parts of antibacterial agent, 15 parts of porogen and 45 parts of deionized water.

[0027] (2) Place the above-mentioned weighed components in a stirrer for stirring, the stirring speed is 90-100rpm, and the stirring time is 80-90min;

[0028] (3) Pour the mixed solution obtained in step (2) into a film-forming device, and freeze-dry in a vacuum freeze dryer for 15h~35h to obtain an antibacterial and anti-inflammatory medical sponge.

[0029] The modified chitosan is a mixture of β-cyclodextrin grafted chitosan and carboxy...

Embodiment 3

[0034] A kind of preparation method of medical hemostatic sponge material, its preparation method comprises the following steps:

[0035] (1) Take each component by weight ratio: 35 parts of hydroxypropyl chitin, 15 parts of modified chitosan, 6 parts of lemon peel pectin, 7 parts of potassium alginate, 8 parts of mupirocin, 4 parts of triglycerol monostearate, 6 parts of plastin, 28 parts of linolenic acid, 6 parts of ethylene glycol, 6 parts of mannose, 4 parts of antibacterial agent, 13 parts of porogen and 39 parts of deionized water.

[0036] (2) Place the above-mentioned weighed components in a stirrer for stirring, the stirring speed is 90-100rpm, and the stirring time is 80-90min;

[0037] (3) Pour the mixed solution obtained in step (2) into a film-forming device, and freeze-dry in a vacuum freeze dryer for 15h~35h to obtain an antibacterial and anti-inflammatory medical sponge.

[0038] The modified chitosan is a mixture of β-cyclodextrin grafted chitosan and carbo...

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PUM

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Abstract

The invention discloses a preparation method of a medical hemostatic sponge material. The preparation method comprises the following steps: weighting all components in parts by weight; putting all the components into a stirrer and stirring at a speed of 90-100 rpm for 80-90 min; pouring the obtained mixed liquor into a film forming device, and putting into a vacuum freeze drying machine for freeze drying for 15-35 hours, so as to obtain an antibacterial anti-inflammation medical sponge. The medical hemostatic sponge material prepared by the method provided by the invention is excellent in diminishing inflammation, stopping bleeding, resisting bacterium, and resisting edema, is good in biocompatibility and mechanical property, has a strong recuperability to damaged tissues, can prevent rebleeding and eliminate virus potential hazards due to gelatin and animal collagen, so that the use safety is greatly improved.

Description

technical field [0001] The invention belongs to the field of new medical materials and relates to a preparation method of a medical hemostatic sponge material. technical background [0002] At present, most of the auxiliary hemostatic materials commonly used in domestic clinical operations are gelatin hemostatic sponges. The medical sponge material used for hemostasis needs to have excellent hydrophilicity, easy to use, excellent ability to adhere to wounds, and short hemostasis time. Apply on the wound surface, the wound surface is dry and not prone to infection, and the wound surface needs to heal quickly; after internal organs have stopped bleeding, the sponge material is preferably degradable and absorbable. In addition, medical sponge materials also need low rejection and good biocompatibility. Although the gelatin hemostatic sponge has a certain auxiliary hemostatic effect, it is still not ideal. Its liquid absorption rate is relatively common, and the liquid absorpt...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/44A61L15/42
Inventor 李苏杨李文遐徐勤霞
Owner SUZHOU BEC BIOLOGICAL TECH
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