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Preparation method of material with nitric oxide (NO) catalytic activity

A technology of catalytically active materials and nitric oxide, which is applied in the direction of medical preparations, dental preparations, and pharmaceutical formulations of non-active ingredients, can solve the problem of no strong binding sites between NO catalytically active materials and material substrates, and it is difficult to maintain NO catalytic release , catalytic release of small amount of NO, etc., to achieve the effect of inhibiting smooth muscle cell proliferation, promoting endothelial cell adhesion, and inhibiting atherosclerosis

Active Publication Date: 2014-12-24
GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many shortcomings in the application of NO catalytically active materials reported so far, such as: (1) The catalytically active materials with GPx are usually grafted on the surface, and the amount of grafting is limited, resulting in the amount of NO catalytically released Small, it is difficult to apply to the environment where large doses of NO are required; (2) Since the synthesized NO catalytic active material has no strong binding site with the material substrate, its stability is poor, and it is difficult to maintain long-term NO catalytic release

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of a material with nitric oxide (NO) catalytic activity, the steps are:

[0023] A, the dopa (Dopa) that concentration is 1mg / mL, the selenocystamine of 1mg / mL and the cupric chloride that concentration is 1mg / mL are dissolved in the PBS buffer solution of pH=5-12, react at room temperature 12 hours.

[0024] B. The reaction solution in step A is centrifuged, washed, dialyzed and freeze-dried to obtain the target nitric oxide (NO) catalytically active material

Embodiment 2

[0026] A preparation method of a material with nitric oxide (NO) catalytic activity, the steps are:

[0027] A. Dissolve Dopamine (Dopamine) with a concentration of 2mg / mL, selenocystamine of 2mg / mL and copper chloride with a concentration of 2mg / mL in Tris buffer solution of pH=5-14, and react at room temperature for 24 Hour.

[0028] B. The reaction solution in step A is centrifuged, washed, dialyzed and freeze-dried to obtain the target nitric oxide (NO) catalytically active material

Embodiment 3

[0030]A preparation method of a material with nitric oxide (NO) catalytic activity, the steps are:

[0031] A. Dissolve norepinephrine with a concentration of 10mg / mL, selenocystamine with a concentration of 10mg / mL and copper chloride with a concentration of 10mg / mL in PBS buffer solution of pH=5-12, and react at room temperature for 12 Hour.

[0032] B. The reaction solution in step A is centrifuged, washed, dialyzed and freeze-dried to obtain the target nitric oxide (NO) catalytically active material

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PUM

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Abstract

The invention discloses a preparation method of a material with nitric oxide (NO) catalytic activity. The preparation method is implemented through the steps that a selenium-containing compound with nitric oxide catalytic activity, a sulfur-containing compound, a soluble copper salt, a compound with an o-phenol structure, a flavonoid compound, and a flavonol compound or a flavanone compound are mixed in a buffer solution and then polymerized. The material with NO catalytic activity not only can be applied to the surface modification of materials which are different in material, geometrical shape and topological structure, and also can be used as a filling material for a controlled release system. Double selenium bonds, double sulfur bonds, copper ions and phenolic hydroxyl groups, which are contained in the prepared material with nitric oxide (NO) catalytic activity, have an excellent free radical removal function; the selenium bonds, the sulfur bonds and the chelate copper ions, which are contained in the material, also have a reduced glutathione (GSH) response function; in addition, the copper ions containing in the material also have an antibacterial function; and the material, besides being used for catalyzing NO release, also can be applied to all related fields of free radical removal and GSH response function.

Description

technical field [0001] The invention relates to a technology for preparing materials with nitric oxide catalytic activity. Background technique [0002] Nobel Prize winners Murad and Ignarro discovered more than 30 years ago that the cell signaling factor NO is a key factor in maintaining the balance of the cardiovascular system. NO is mainly produced by endothelial cells through the action of nitric oxide synthase secreted by endothelial cells and arginine. The sustained release of NO is an important factor in maintaining cardiovascular homeostasis and regulating vasodilation. In addition, the researchers also found that NO has many important biological effects, such as: inhibition of platelet activation, smooth muscle proliferation and leukocyte activation. It also has important biological functions in immune response, anticancer, antibacterial and atherosclerotic treatment. It is worth mentioning that the study found that NO also plays an important role in the mobilizat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/14A61L27/54A61L31/04A61L31/16A61K47/30A61K6/08A61K6/884
Inventor 黄楠杨志禄王进齐鹏凯涂秋芬杨莹熊开琴翁亚军李龙李亚龙
Owner GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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