Tamsulosin hydrochloride sustained-release capsule and preparation method thereof
A technology of tamsulosin hydrochloride and sustained-release capsules, which is applied in the field of oral chemical drug sustained-release preparations, can solve problems such as poor content uniformity, and achieve the effects of low cost, significant economic benefits, and simple and feasible preparation process
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Embodiment 1
[0039] Prescription and Preparation of Blank Ball Core
[0040]
[0041] Get the microcrystalline cellulose, sorbitol, starch, lactose of recipe quantity and put in centrifugal granulator, use water as binding agent, make the blank ball core that 20 mesh particle diameters are 0.5-2mm;
[0042] Prescription and preparation of the drug-containing layer: 1000 prescriptions
[0043]
[0044] 1. Weigh potassium dihydrogen phosphate and hydroxypropyl-β-cyclodextrin by weight percentage, and make an aqueous solution of 2-6% adhesive with a viscosity of 20mpa.s-35mpa.s;
[0045] 2. Dissolving tamsulosin hydrochloride in the solution in step 1 and stirring slowly to obtain a drug-containing solution, wherein the concentration of tamsulosin hydrochloride solution is 0.08-0.25% by weight;
[0046] 3. The blank ball core is added to the fluidized bed, coated with the drug-containing solution in step 2, and dried to obtain drug-containing pellets of tamsulosin hydrochloride;
[00...
Embodiment 2
[0052] The preparation of blank ball core is identical with embodiment 1;
[0053] The prescription for the drug-containing layer is as follows:
[0054]
[0055] The coating prescription is as follows:
[0056]
[0057] The preparation method is the same as in Example 1.
Embodiment 3
[0059] The preparation of blank ball core is identical with embodiment 1;
[0060] The prescription for the drug-containing layer is as follows:
[0061]
[0062] The coating prescription is as follows:
[0063]
[0064] The preparation method is the same as in Example 1.
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