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Silver-bearing ntimicrobial dressing and preparation method thereof

An aqueous solution and chloride ion technology, applied in the field of medicine and health, to achieve the effect of fast sterilization, less impurities and improved safety

Active Publication Date: 2015-08-26
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there is no report on the combination of silver ions, silver chloride nanoparticles and elemental nano-silver into natural polymer dressings.

Method used

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  • Silver-bearing ntimicrobial dressing and preparation method thereof
  • Silver-bearing ntimicrobial dressing and preparation method thereof
  • Silver-bearing ntimicrobial dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A preparation method of silver-containing antibacterial dressing, comprising the steps of:

[0045] 1) in the chitosan solution that mass concentration is 0.5%, drip sodium chloride aqueous solution and calcium chloride aqueous solution, make the concentration of chloride ion reach 10ppm; The solvent of chitosan solution is the acetic acid aqueous solution of 0.05M;

[0046] 2) Mix the silver nitrate aqueous solution with a mass concentration of 0.5% with the solution obtained in step 1) at a ratio of 1:1 by volume;

[0047] 3) Under sunlight excitation, react for 2 hours; X-ray crystallography analysis ( figure 1 ) proves that there are two crystal forms of silver chloride and nano-silver in the solution at this time;

[0048] 4) Mix the liquid obtained in step 3) with the collagen solution with a mass concentration of 0.2% according to the volume ratio of 1:10, pre-freeze at -20°C, and freeze-dry; the solvent of the collagen solution is 0.8M Aqueous solution of acet...

Embodiment 2

[0051] 1) adding magnesium chloride aqueous solution dropwise to the sodium alginate aqueous solution with a mass concentration of 0.6%, so that the concentration of chloride ions reaches 15ppm;

[0052] 2) According to the ratio of 9:1 by volume, the silver nitrate aqueous solution with a mass concentration of 0.05% is mixed evenly with the solution obtained in step 1);

[0053] 3) Under the excitation of visible light with a wavelength of 404nm and an illumination of 300lux, react for 24 hours;

[0054] 4) Mix the liquid obtained in step 3) with the gelatin aqueous solution with a mass concentration of 0.6% according to the volume ratio of 1:6, pre-freeze at -40°C, and freeze-dry;

[0055] 5) cutting, encapsulating, and sterilizing.

Embodiment 3

[0057] 1) Add barium chloride aqueous solution dropwise to the hyaluronic acid aqueous solution with a mass concentration of 0.4%, so that the concentration of chloride ions reaches 10ppm;

[0058] 2) Mix the silver nitrate aqueous solution with a mass concentration of 0.2% with the solution obtained in step 1) in a ratio of 3:2 by volume;

[0059] 3) Under the excitation of visible light with a wavelength of 486nm and an illumination of 20,000 lux, react for 30 hours;

[0060] 4) Mix the liquid obtained in step 3) with a 0.5% sodium alginate aqueous solution at a volume ratio of 1:7 evenly, pre-freeze at -80°C, and freeze-dry;

[0061] 5) cutting, encapsulating, and sterilizing.

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Abstract

The invention discloses a silver-bearing ntimicrobial dressing and a preparation method thereof. The preparation method comprises the following preparation steps: 1) dropwise adding a chloride ion brine solution in a polysaccharide solution; 2) uniformly mixing a silver nitrate water solution with the solution obtained from the step 1); 3) reacting under optical excitation; 4) uniformly mixing the liquid obtained from the step 3) with a natural macromolecular solution, and performing pre-freezing and freeze-drying; 5) cutting, packing and sterilizing. The mechanical property of the dressing is improved through selection and proportion of natural polymers, and the degradation rate of the dressing is adjusted. Since being protected by the natural polymers, the dressing has the advantages that the nanostructure is uniform in dispersion, the stability is good, the sterilizing speed is high, and silver ions are continuously and stably released. The natural polymers are taken as a base material, and have the three-dimensional porous structure characteristics, so that when exerting the sterilizing function, the dressing has good hygroscopicity, degradability and biocompatibility. The product prepared according to the preparation method can be used for clinically treating skin defective infection caused by various reasons.

Description

technical field [0001] The invention belongs to the technical field of medicine and hygiene, and in particular relates to a silver-containing antibacterial dressing and a preparation method thereof. Background technique [0002] Skin injury is a common clinical disease. Eczema, dermatitis, pressure sores, trauma, burns, ulcers, etc. can cause skin injuries. Correct treatment of wounds is the key to the treatment of such diseases. Active wound management can effectively promote wound healing, improve prognosis and reduce disability. Wound dressings made of natural polymers can form a gel protective film on the wound surface, which has the advantages of biocompatibility, good degradability, high hygroscopicity, easy removal, rapid hemostasis, and accelerated wound healing. However, these new dressings are susceptible to bacterial infection, potentially dangerous to the wound and the organism surrounding it. Silver-based antibacterial agents have a long history, low drug resi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/44
Inventor 关嫚段瑞平周志敏李学敏刘玲蓉张其清
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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