Active extract for promoting fracture healing and application of active extract

A fracture healing and extract technology, applied in the field of Chinese herbal extracts, can solve problems such as poor curative effect, unsatisfactory curative effect, and health hazards of patients, so as to accelerate the organization and absorption of hematoma, promote osteoblast proliferation, and improve local The effect of blood circulation

Inactive Publication Date: 2015-08-26
强红枫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the general Western medicine treatment method is to prescribe the right medicine, reduce inflammation and relieve pain, and temporarily control pain. However, this treatment method will cause dependence on the drug, has relatively large side effects, and is harmful to the health of patients. After reduction, use splint or plaster for external fixation and supplement with necessary internal and external medication, but this will bring greater pain to the patient, the healing speed is slower, and the curative effect is not ideal
In addition, with the development of the traditional Chinese medicine industry, more and more traditional Chinese medicine prescriptions for treating bone injuries and fractures have been disclosed. It is very common to use traditional Chinese medicine prescriptions combined with physical therapy to treat bone injuries and fractures, but they are often either expensive or curative. bad

Method used

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  • Active extract for promoting fracture healing and application of active extract
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of Chinese medicine dry plaster powder

[0014] Prescription: Xuelikai 2.3kg, dried ginger 5.0kg, Niu Dali 2.3kg, crape myrtle flower 2.5kg, Ferulicum 0.15kg.

[0015] Preparation method: Take the above-mentioned raw materials of Chinese medicinal materials in the prescribed amount, crush them, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, and add up to 12 times the medicinal materials for the first time amount of water, decoct for 2 hours, take the decoction, filter, add 10 times the amount of water of the medicinal materials for the second time, decoct for 1.5 hours, take the two decoctions and combine, filter, and the relative density when concentrated to 65°C is Concentrate of 1.05; add appropriate amount of ethanol to make the volume percentage of alcohol reach 75%, refrigerate at 0°C for 24 hours, filter, recove...

Embodiment 2

[0016] Embodiment 2: the preparation of bone ointment

[0017] Prescription: 4.0g Chinese medicine dry cream powder, 30.0g stearic acid, 4.0g triethanolamine, 8.0g glycerin, 6.0g lanolin, 50ml liquid paraffin, 100ml distilled water.

[0018] Preparation method: Weigh stearic acid, lanolin, and liquid paraffin in the prescribed amount, put them in a container, heat and melt in a water bath to obtain an oil phase, and keep warm at 85°C for later use. Separately take the prescribed amount of Chinese medicine dry paste powder (prepared in Example 1) and triethanolamine, dissolve in distilled water, heat to 85°C to obtain the water phase, slowly add the water phase to the oil phase, and keep stirring in the same direction until the white fine paste shape.

Embodiment 3

[0019] Embodiment 3: Fracture healing experiment in rats

[0020] 20 SD male rats (170±10g) were randomly divided into 2 groups: blank control group and bone-sintering cream group, 10 rats in each group. Each mouse was injected intraperitoneally with 0.352ml / 100g of 10% chloral hydrate. After the righting reaction disappeared, the supine position was fixed, the hair on the right hind limb was removed, the skin was disinfected with iodine, and the skin was cut longitudinally along the lower lateral side of the right posterior tibial tuberosity for 1.5 ~2cm, separate the muscles, avoid the blood vessels and nerves, expose the tibia, and create a bone defect of 1mm×2mm at about 1.5cm below the tibial tuberosity. The wound was sutured layer by layer (the wound was removed 7 days after the operation) to bandage the wound, but it was not fixed. Three days after modeling, each rat was intramuscularly injected with 0.3ml of 4mg / 1ml gentamicin. On the 3rd day after the operation, the...

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Abstract

The invention discloses an active extract for promoting fracture healing and application of the active extract. The active extract is prepared from the following raw traditional Chinese medicinal materials by weight: 18 to 30 parts of henry clematis root, 40 to 60 parts of rhizoma zingiberis, 18 to 30 parts of beautiful millettia root, 20 to 30 parts of jakaranda and 1 to 2 parts of asafoetida. The active extract can be used for accelerating local hematoma organization and absorption of a fracture, improving local blood circulation, promoting osteoblast multiplication, and accelerating osteotylus filling and bone trabeculation, thereby significantly accelerating fracture healing.

Description

technical field [0001] The invention belongs to the technical field of extracts of traditional Chinese medicinal materials, and in particular relates to an active extract for promoting fracture healing and its application. Background technique [0002] Fracture refers to a clinical condition in which the integrity of bone or trabecular bone is destroyed while involving soft tissues, joints, muscles, ligaments, blood vessels and nerves around the injury. Fractures not only lead to bone tissue damage, but also lead to severe pain at the fracture site, inflammation and blood stasis and other complications. [0003] According to current statistics, nearly 12 million people suffer fractures every year in my country. So far, the general Western medicine treatment method is to prescribe the right medicine, reduce inflammation and relieve pain, and temporarily control pain. However, this treatment method will cause dependence on the drug, has relatively large side effects, and is h...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P19/08
Inventor 强红枫
Owner 强红枫
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