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Application of traditional Chinese medicine Burnet in the preparation of antifungal drug synergists

The technology of an antifungal drug and a synergist, applied in the field of medicine, can solve the problems such as no related reports on synergistic antifungal synergistic drugs, and achieve the effects of improving the antifungal effect, enriching resources and enhancing the inhibitory effect.

Inactive Publication Date: 2018-11-02
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report about Burnet's antifungal effect, nor has it been reported as a synergistic antifungal synergistic drug

Method used

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  • Application of traditional Chinese medicine Burnet in the preparation of antifungal drug synergists
  • Application of traditional Chinese medicine Burnet in the preparation of antifungal drug synergists
  • Application of traditional Chinese medicine Burnet in the preparation of antifungal drug synergists

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: The effect of raw Burnet and antifungal drugs combined with 7 strains of Candida

[0014] 1. Materials and methods

[0015] 1. Reagents

[0016] Raw Burnet: Department of Traditional Chinese Medicine, Shanghai Leiyunshang Pharmaceutical Co., Ltd.

[0017] Burnet Charcoal: Department of Traditional Chinese Medicine, Shanghai Leiyunshang Pharmaceutical Co., Ltd.

[0018] Fluconazole injection: Pfizer Pharmaceutical Co., Ltd.

[0019] Absolute ethanol: Shanghai Sinopharm Group Co., Ltd.

[0020] Petroleum ether: Shanghai Sinopharm Group Co., Ltd.

[0021] Ethyl acetate: Shanghai Sinopharm Group Co., Ltd.

[0022] Butanol: Shanghai Sinopharm Group Co., Ltd.

[0023] Preparation of traditional Chinese medicine extract: Take 5g of raw Burnet and Burnet charcoal Chinese medicine powder respectively, add 50ml of 70% ethanol solution, ultrasonicate at 50KHz for 40 minutes at room temperature, repeat ultrasonication twice after cooling, centrifuge at 3000×g fo...

Embodiment 2

[0057] Embodiment 2: Raw Burnet, the effect of Burnet charcoal and antifungal drugs on Candida albicans 103, SC5314

[0058] 1. Materials and methods

[0059] 1. Drugs

[0060] Fluconazole Injection Pfizer Pharmaceutical Co., Ltd.

[0061] Caspofungin Acetate Merck sharp&Dohme (I.A.) CORP Singapore

[0062] Terbinafine Hydrochloride Xi'an Kaihong Biotechnology Co., Ltd.

[0063] Amphotericin B Pfizer Pharmaceuticals LLC

[0064] Dimethyl sulfoxide Shanghai Sinopharm Group Co., Ltd.

[0065] Caspofungin acetate, terbinafine, and amphotericin B were dissolved in dimethyl sulfoxide to form a 6.4 mg / ml solution, and each reagent was stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.

[0066] Other experimental steps and methods are the same as in Example 1

[0067] 2. The experimental results are shown in Table 2, Table 3, Table 4, and Table 5.

[0068] ...

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Abstract

The invention belongs to the technical field of medicine, and more specifically relates to applications of traditional Chinese medicine sanguisorba officinalis in preparing an antifungal drug synergist. It is confirmed by in vivo experiments that sanguisorba officinalis possesses synergistic effects with routine antifungal drugs such as fluconazole, miconazole, caspofungin, and amphotericin B; with regard to drug resistance funguses, when the antifungal drugs are combined with sanguisorba officinalis, drug dose of the routine antifungal drugs can be reduced obviously, inhibiting effects of the routine antifungal drugs on funguses can be improved to different degrees, effects of the antifungal drugs on the drug resistance funguses can be recovered, and inhibiting effects on the drug resistance funguses are improved. Novel applications of traditional Chinese medicine sanguisorba officinalis are provided; clinical fungus drug resistance can be widely observed, and drug resistant degree becomes higher, drug dose of the antifungal drugs can be reduced, medical cost is reduced for patients, and drug toxic and side effects are reduced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of traditional Chinese medicine Burnet eucalyptus in the preparation of synergists for antifungal drugs. Background technique [0002] Burnet is the dry root of Sanguisorba officinalis L or Sanguisorba officinalis L.var.longifolia (Bert.) Yüet Li, a plant of the family Rosaceae. It is produced all over the country, mainly in Zhejiang, Anhui, Shandong, Hunan, Hubei and other places. Burnet eucalyptus is slightly cold in nature, bitter, astringent, and sour. It returns to the liver, stomach, and large intestine meridian. Treatment of diseases such as swollen sores (see: Qing Sun Xingyan, Sun Xingyi Collection. Shennong's Herbal Classic [M]. Beijing: Commercial Press, 1955.94.). [0003] Burnet also has antibacterial and anti-inflammatory effects, but it is mainly concentrated on Staphylococcus aureus, Pseudomonas aeruginosa and other bacteria (see literature: Wu ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/739A61K45/00A61P31/10
Inventor 曹永兵叶招浇姜远英刘谋志阎澜李洪娇王彦曹颖瑛汪瑞莲
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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