Method and System for Leading Macromolecule Substances into Living Target Cells

Abstract

A method and system for leading macromolecule substances into target cells includes an image picking unit, an image merging unit, an injection unit, and an energy conversion module. The image picking unit is used for picking up the three-dimensional (3D) and the 3D blood vessel photographic images of the tissue or organ where the target cells locate. The image merging unit is used for merging the 3D structure images into the 3D blood vessel photographic images, therefore choosing a blood vessel passage fully covering the target cells for transmitting the macromolecule substances. The injection unit is used for injecting liquid and transmitting the macromolecule substances to the target cells. The energy conversion module is used for exerting energy to activate the liquid to perform biological effects, thereby forming non-permanent holes in the cell membranes of the target cells. The macromolecule substances enter into the target cells through the non-permanent holes.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]Under 35 U.S.C. § 120 the present Application is a Continuation of U.S. patent application Ser. No. 10 / 767,387, filed Jan. 28, 2004, entitled “Method and System for Leading Macromolecule Substances into Living Target Cells” which claims priority to foreign Taiwan Application No. 092128522, filed Oct. 15, 2003, all of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates generally to a method and system for leading macromolecule substances into living target cells, and more particularly, to a method and system which applies ultrasonic wave to adjust the permeability of cell membranes of the target cells, thereby efficiently leading low dosage macromolecule substances into the target cells.BACKGROUND OF THE INVENTION[0003]Tissue cells of a human body are sometimes stimulated by inner or outer harmful factors which make them ill. As a result, the number of ill cells increases rapidly, and the ill ...

AI Technical Summary

Benefits of technology

[0006]The primary objective of the present invention is to provide a method and system for efficiently leading macromolecule substances into target cells.

[0007]Another objective of the present invention is to provide a method and system applied in gene delivery, which increases the efficiency of gene delivery.

[0008]A further objective of the present invention is to provide a method and system applied in gene therapy, which improves the efficiency of gene therapy.

[0009]And yet another objective of the present invention is to provide a method and system for improving medication precision.

[0010]Still another objective of the present invention is to provide a method and system for lowering medicine dosage and efficiently leading the medicine into tumor cells.

[0013]Compared with conventional medication method and system, the method and system for leading macromolecule substances into living target cells of present invention picks up the 3D structure images of the tissue or organ where the target cells locate, and the 3D blood vessel photographic images of the tissue or organ where the target cells locate, merges the 3D structure images into the 3D blood vessel photographic images, thereby precisely locating the target cells for choosing a most efficient blood vessel passage fully covering the target cells, and injects the macromolecule substances into the target cells along the chosen blood vessel passage. Then, the method and system exerts energy to activate tiny bubbles liquid arranged around the target cells to perform biological effects, thereby forming non-permanent holes in the cell membranes of the target cells. The macromolecule substances enter into the target cells through the non-permanent holes in the cell membranes thereof. Thus the method and system for leading macromolecule substances into living target cells of present invention has many advantages, such as low medicine dosage, low cost, precisely medication, and efficient curative effect.

Problems solved by technology

Compared with benign tumors, malignant tumors are hard to cure, and do a greater harm to human bodies.

In a chemotherapy treatment, health of a tumor patient is generally threatened by yet-to-solved limitations and drawbacks of low medication precision, which distributes toxicity of medicines to the human bodies.

However, the method does not disclose how to precisely locate the target cells and how to improve the medication precision.

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