A compound medicine for treating ulcerative colitis and its preparation method and application

Abstract

The invention discloses a compound combination medicine for treating ulcerative colitis, which comprises the following components in parts by weight: 2-9 parts of Coptis rhizome, 6-15 parts of Scutellaria baicalensis, 10-30 parts of Patrinia, 6-30 parts of fried angelica 20 parts, 5-20 parts of fried white peony, 5-15 parts of raw Burnet, 5-20 parts of comfrey, 5-15 parts of madder, 6-15 parts of Angelica dahurica, 3-12 parts of simmering wood fragrance, 2-6 parts of raw licorice share. The invention also discloses the preparation method and application of the compound medicine. The present invention provides an effective therapeutic drug for the clinical treatment of ulcerative colitis, an intractable disease, and is economical and practical, and has broad clinical application prospects; its preparation method is simple, fast, efficient, easy to operate, and the prepared granules are portable and convenient. take.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a compound medicine for treating ulcerative colitis and its preparation method and application Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific inflammation that mainly involves rectal and colonic mucosa, and belongs to the category of inflammatory bowel disease. Its course of disease is characterized by chronicity, delay, recurrent attacks, and the possibility of canceration. Because of its unknown etiology, difficult to cure, and easy to relapse, it is listed as a difficult disease by the World Health Organization. [0003] At present, Western medicine treatment drugs for UC include: ①Aminosalicylic acid preparation, which is the current first-line drug, but sulfasalazine has obvious toxic and side effects; Taking for a long time, the curative effect of controlling recurrence is not ideal yet. ②Glucocorticoids: ...

AI Technical Summary

Problems solved by technology

[0003] At present, Western medicine treatment drugs for UC include: ①Aminosalicylic acid preparation, which is the current first-line drug, but sulfasalazine has obvious toxic and side effects; Long-term use, the curative effect of controlling recurrence is not satisfactory

②Glucocorticoids: mainly hydrocortisone succinate, prednisolone, methylprednisolone, etc., which are prone to drug dependence, have obvious side effects, and are difficult to use for a long time

③ Immunosuppressants: mainly cyclosporine, azathioprine, and 6-mercaptopurine, which have obvious toxic and side effects, and are only used in cases where the above-mentioned treatments are ineffective, and the curative effect is uncertain

[0004] The pathogenesis of the disease is emphasized in the active stage and the remission stage. In the active stage of the disease, there are mostly pathological changes in the intestines with damp heat, qi stagnation and blood stasis, and meat rot and blood stasis. Addition and subtraction of Shaoyao Decoction or Pulsatilla Decoction, commonly used Coptidis, Scutellaria, Phellodendron Phellodendron, Pulsatilla, Qinpi and other bitter and cold products, it is worth noting that excessive use of bitter cold not only hinders the health of the spleen and stomach, but also has the disadvantages of cooling and heat poison and reducing dryness and impairing yin

At the same time, the active stage of ulcerative colitis is mainly characterized by damp heat and blood stasis, and attention should be paid to the treatment of clearing the intestines to remove dampness, cooling blood and stopping bleeding. Currently, there is no compound drug with the best drug ratio in clinical practice, and it cannot be popularized and used.

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