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Acoustic surface wave based microfluidic plasma separating chip and method

A plasma separation and surface acoustic wave technology, applied in the direction of stress-stimulated microbial growth, etc., can solve the problems of difficulty in separating plasma, small cell offset, etc., and achieve easy integrated manufacturing, high energy density, and reduced precision requirements. Effect

Active Publication Date: 2015-06-24
XI AN JIAOTONG UNIV
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Problems solved by technology

Although this design can achieve efficient cell sorting, it is difficult to meet the requirements of separating plasma from blood due to the very small offset of cells and only suitable for extremely low cell densities

Method used

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  • Acoustic surface wave based microfluidic plasma separating chip and method
  • Acoustic surface wave based microfluidic plasma separating chip and method
  • Acoustic surface wave based microfluidic plasma separating chip and method

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Embodiment Construction

[0034] The structural features and working principles of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0035] see Figure 1a to Figure 3 As shown, a microfluidic blood plasma separation chip based on surface acoustic waves of the present invention includes a piezoelectric substrate 1, a group of interdigital transducers 2 on the piezoelectric substrate 1, and a group of interdigital transducers 2 bonded to the piezoelectric substrate. A flow microchannel system 3 with a radially constricted structure on the side of the interdigital transducer 2 on 1.

[0036] The interdigital transducer 2 includes several pairs of interdigitators, which are used to generate surface acoustic waves on the surface of the piezoelectric substrate 1 . The flow microchannel system 3 is used to accommodate blood samples to be separated, provide space for cell migration and aggregation, and send the pooled blood cells and plasma to different o...

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Abstract

The invention discloses an acoustic surface wave based microfluidic plasma separating chip and method. The chip comprises a piezoelectric substrate, a set of interdigital transducer arranged on the piezoelectric substrate and a flow microchannel system which is arranged on the piezoelectric substrate in a bonding manner, located on one side of the interdigital transducer and has a necking structure. According to the chip, by use of width change of a microchannel, blood cells gradually shift to one side of a runner under the action of an acoustic radiation force, thus realizing the separation of plasma and blood cells. The chip takes such good advantages of the acoustic surface wave based microfluidic particle separation technology as high energy density and easy integration and manufacturing; in addition, only one set of interdigital transducer is arranged on the piezoelectric substrate and the distribution of an acoustic surface standing wave field is defined by a special geometrical shape of the PDMS flow microchannel; therefore, the defect that the existing acoustic surface wave based microfluidic particle separation technology requires two sets of interdigital transducer at the same time is overcome, the size of the separation chip is reduced further, and the requirement on alignment precision of the interdigital transducer and the microchannel system is reduced greatly.

Description

【Technical field】 [0001] The invention relates to the technical field of biological sample processing, in particular to a plasma separation chip and method. 【Background technique】 [0002] Blood is one of the most important fluids in the human body, and its components are often affected by physiological and pathological changes in the human body, so the detection of blood components has important clinical significance. Blood consists of blood cells and plasma. Blood cells mainly include red blood cells, white blood cells and platelets. Plasma accounts for about 55% of the blood volume, and 90% of its components are water. It also contains various nutrients and metabolites such as inorganic salts, fibrinogen, albumin, globulin, enzymes, and hormones. These substances have no definite form, but have important physiological functions, so about 90% of blood tests use plasma as a sample. The separation of plasma from whole blood is therefore an essential step in the blood anal...

Claims

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Application Information

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IPC IPC(8): C12M1/42
Inventor 韦学勇张静静蒋庄德任娟刘小龙
Owner XI AN JIAOTONG UNIV
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