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Porous calc silicate bioceramic material, preparation method and application

A calcium silicate, porous material technology, applied in the field of biomedical materials, can solve the problems of different mechanical properties, degradation properties and regeneration efficiency requirements, limitations that have not been paid attention to by the academic community, and poor mechanical strength of porous ceramics. Efficiency and progress of bone regeneration, favorable cell migration, and easily adjustable scale effects

Active Publication Date: 2015-06-17
ZHEJIANG UNIV
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  • Application Information

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Problems solved by technology

A higher content of magnesium introduces or forms a series of new mineral phases, thus forming new bioceramic materials with different characteristics, such as diopside has high mechanical strength, but degrades very slowly; Promoting osteoblast activity is significantly better than other calcium-magnesium silicate ceramics and wollastonite, but there are differences in mechanical properties, degradation properties and regeneration efficiency requirements
The mechanical strength of porous ceramics constructed by several other calcium silicate minerals containing heterogeneous ions is poor
At the same time, the limitations of various mineral phases formed by heterogeneous ion doping wollastonite have not been paid much attention by the academic community.
[0006] According to the existing technology research, there is an urgent need to explore high-strength degradable bioactive materials that are more ideal for rapid and complete repair of various bone injuries in the human body in terms of chemical composition, mechanical properties and biological effects. Such materials must not only have the ability to actively regulate the proliferation and differentiation of osteogenesis-related (stem) cells at the cellular and molecular levels, but also have the microstructure of the material, especially the mechanical support under the condition of interpenetrating pores, be sufficient to support load-bearing bone or thin bone. The inherent requirements of bone regeneration and repair at the parietal bone site, and the degradation performance closer to the bone regeneration efficiency of each part, such biomaterials, such as metals, alloys, inert ceramics, polymers and other materials, cannot meet the requirements, and only bioactive ceramics can pass through. Innovative design and optimized construction, and become a new generation of bone regeneration repair materials to solve a large number of clinical problems

Method used

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  • Porous calc silicate bioceramic material, preparation method and application
  • Porous calc silicate bioceramic material, preparation method and application
  • Porous calc silicate bioceramic material, preparation method and application

Examples

Experimental program
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Embodiment 1

[0049] Example 1: [Zinc and magnesium co-doped β-calcium silicate porous ceramic material]

[0050] 1) Put 250 mL of 0.28 mol / L Ca (NO 3 ) 2 , 0.014 mol / L ZnCl 2 , 0.014 mol / L Mg (NO 3 ) 2 The pH of the aqueous solution was adjusted to 10.6, and the solution was added dropwise to 0.308 mol / L Na with a pH of 10.6 and a volume of 250 mL. 2 SiO 3 In the aqueous solution, continue to stir for 120 minutes after the dropwise addition, then filter the reaction sediment, wash twice with deionized water, and then wash three times with absolute ethanol, at 80 o Dry at C, after 1000 o Calcined at C for 3 hours, and then ball-milled for 4 hours to obtain zinc and magnesium co-doped β-calcium silicate powders with a particle size of 0.5-3 μm. tested by X-ray diffraction (eg figure 1 It is proved that the phase of the powder is pure β-calcium silicate, and the mass content of zinc and magnesium in the powder is 2.25% and 1.07%, respectively, by atomic absorption spectrometry.

[0...

Embodiment 2

[0052] Example 2: [Boron and magnesium co-doped α-calcium silicate ceramic porous material]

[0053] 1) Mix 500 mL of 0.30 mol / L CaCl 2 , 0.018 mol / L MgCl 2 The pH of the aqueous solution was adjusted to 10.6, and the solution was added dropwise to 0.30 mol / L Na with a pH of 10.2 and a volume of 500 mL. 2 SiO 3、 0.018 mol / L HBO 3 In the aqueous solution, continue stirring for 180 minutes after the dropwise addition, and then filter the reaction deposit, wash twice with deionized water, and then wash three times with absolute ethanol, at 120 o Drying under C, after 1220 o calcined at C for 2 hours, and then ball-milled for 6 hours to obtain powders with a particle size of 0.8-5.0 μm. The X-ray diffraction test proves that the powder is α-calcium silicate and does not exist any other crystalline phase substances (such as Image 6 The content of boron and magnesium in the α-calcium silicate powder is 0.78% and 1.18%, respectively. Boron and magnesium co-doped α-calcium sil...

Embodiment 3

[0055] Example 3: [Zinc, magnesium, boron co-doped β-calcium silicate ceramic porous material]

[0056] 1) 500 mL of 0.30 mol / L Ca (NO 3 ) 2 , 0.009 mol / L ZnCl 2 , 0.018 mol / L Mg (NO 3 ) 2 The pH value of the aqueous solution was adjusted to 10.5, and the solution was added dropwise to 0.32 mol / L Na with a pH of 10.5 and a volume of 500 mL. 2 SiO 3、 0.007 mol / L HBO 3 In the aqueous solution, continue to stir for 90 minutes after the dropwise addition, then filter the reaction sediment, wash it with deionized water 4 times, and then wash it with absolute ethanol 2 times, at 120 o Dry at C, after 950 o Calcined at C for 2 hours, and then ball-milled for 6 hours to obtain zinc, magnesium and boron co-doped β-calcium silicate powder with particle size of 0.3-2 μm. The X-ray diffraction test proves that the powder phase is pure β-calcium silicate, and there is no other crystalline phase. The atomic absorption spectrometry analysis and test show that the mass content of zinc...

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Abstract

The invention discloses a porous calc silicate bioceramic material, a preparation method and application. The porous bioceramic material comprises the following components in an oxide form in percentage by weight: 44 to 52 percent of CaO, 47 to 54 percent of SiO2, 0 to 3.0 percent of B2O3, 0 to 3.4 percent of ZnO and 0.2 to 4.8 percent of MgO, wherein the content of B2O3 and ZnO is not simultaneously 0; the ratio of the content of MgO and the content sum of B2O3 and ZnO is 1:(0.2-5). The preparation method comprises the following steps: preparing boron, zinc and magnesium-containing calc silicate superfine powder by using a wet-chemical method and a sol-gel method, preparing a porous material of which the shape is consistent with that of a skeleton of each part of a human body and the pore passage size is 80 to 800[mu]m by using a three-dimensional printing technology, and performing high-temperature sintering treatment. The material can be applied to the bone defect repair and bone regeneration medicine of the department of orthopedics, department of stomatology, plastic surgery, maxillofacial surgery, thoracic surgery department or ophthalmology department.

Description

technical field [0001] The invention relates to biomedical materials, in particular to a calcium silicate bioceramic porous material for promoting regeneration and repair of bone damage, a preparation method and an application. Background technique [0002] The rapid and complete regeneration and repair of a series of bone injuries, such as bone defects caused by mechanical force, bone loss caused by osteoporosis, and bone tissue necrosis caused by bone tumors and inflammation, has always been a research hotspot in related fields, and it is also a current clinical research topic. Medical conundrum. Different parts of the human body have different bone shape, thickness, and ability to bear mechanical loads, and the efficiency of bone damage repair under different ages and pathological conditions is also completely different. Since ancient times, human beings have mainly relied on metals, alloys with high mechanical bearing capacity or inert ceramic artificial materials with ...

Claims

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Application Information

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IPC IPC(8): C04B38/00C04B35/22B33Y70/00B33Y10/00A61L27/10A61L27/56
Inventor 苟中入
Owner ZHEJIANG UNIV
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