Single-sided bacterial cellulose/polypropylene composite sticking patch for repairing abdominal wall coloboma and preparation method of single-sided bacterial cellulose/polypropylene composite sticking patch

Abstract

The invention relates to a single-sided bacterial cellulose / polypropylene composite sticking patch suitable for intra-abdominal repair and a preparation method of the single-sided bacterial cellulose / polypropylene composite sticking patch. The single-sided bacterial cellulose / polypropylene composite sticking patch is a double-layer sticking patch with a bacterial cellulose layer and a polypropylene layer, and the preparation method comprises the following steps: floating sterilized polypropylene meshes on the surface of a bacterial cellulose culture solution, standing for compound culture 3-5 days, then taking out a fermentation product, and treating the fermentation product by using chemical reagents of acids, alkalis and the like to obtain the single-sided bacterial cellulose / polypropylene composite sticking patch for repairing abdominal wall coloboma. According to the composite sticking patch provided by the invention, the bacterial cellulose layer serving as an abdominal cavity surface is good in biocompatibility and can reduce adhesion of abdominal internal organs; and the polypropylene layer serving as an abdominal wall surface can be firmly fixed with an abdominal wall by virtue of adhesion with the abdominal wall, thereby ensuring the repairing effect and reducing the disease relapse rate.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a single-sided bacterial cellulose / polypropylene composite patch for repairing abdominal wall defects and a preparation method thereof. Background technique [0002] Abdominal wall defect, also known as abdominal external hernia, refers to a defect or weakness in a certain part of the abdominal wall, which makes the abdominal viscera and peritoneum protrude to the body surface through the weak part or hole of the abdominal wall to form a local mass, which can cause pain, intestinal obstruction and other discomfort. In surgical treatment methods, tension-free repair relying on the implantation of mesh has become the mainstream surgical method. Most of the mesh is made of artificial polymer materials represented by polypropylene. With the application of surgical methods, the placement of the patch was changed from extraperitoneal to intraperitoneal, and the results of animal experi...

AI Technical Summary

Problems solved by technology

As far as the current situation is concerned, the existing intra-abdominal repair materials still have relatively many complications such as intestinal obstruction, infection, and hernia recurrence, and rely on imports, which are expensive and not conducive to widespread clinical application.