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Method for simultaneously extracting silybum marianum oil and silymarin from silybum marianum cake

A technology for silymarin and silymarin oil, which is applied in the directions of fat oil/fat production, fat production, organic chemistry, etc., can solve the problems of inability to achieve continuous, industrialized production, environmental pollution, and high production costs, and solves the problem of large solvent input. , no environmental pollution, low production cost

Active Publication Date: 2015-06-03
安徽嘉旗粮油工程技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its shortcoming is that two sets of extraction devices need to be built, the equipment investment is large, the production cycle is long, the power consumption is large, and the production cost is high; a kind of silymarin extraction process using ethanol as a single organic solvent is disclosed in the prior art, and the method uses ethanol Extraction of silymarin requires multiple elutions with water and sodium carbonate. The elution water causes great pollution to the environment, and it is intermittent production, which cannot realize continuous and industrial production. Moreover, the solvent ratio is large, energy consumption is large, and production costs are high. high

Method used

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  • Method for simultaneously extracting silybum marianum oil and silymarin from silybum marianum cake
  • Method for simultaneously extracting silybum marianum oil and silymarin from silybum marianum cake
  • Method for simultaneously extracting silybum marianum oil and silymarin from silybum marianum cake

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Embodiment 1

[0040] Embodiment 1: The production method of simultaneously extracting milk thistle oil and silymarin from milk thistle cake of the present embodiment is as follows:

[0041] (a) The cold-pressed milk thistle cake is transported to the extractor by the material seal conveyor, and at a temperature of 45°C, successively pass through the milk thistle oil with a mass concentration of 15.5%, 13.5%, 9.0%, 5.0%, 2.5%, 1.2%, and 0.4% solvents are subjected to seven-stage spray soaking extraction, and then solvent spray soaking extraction to achieve multi-stage pulse countercurrent extraction. The extraction time is 75min, and extracts containing silymarin oil and silymarin mixed liquid, and the remaining milk thistle pulp;

[0042] Wherein, the solvent used in the extraction process is a mixed solvent of methanol and n-hexane with a mass ratio of 0.6:1, and the mass ratio of solvent to milk thistle cake is 1.5:1;

[0043] After extraction, the residual mass fraction of milk thistle ...

Embodiment 2

[0051] Embodiment 2: The production method of simultaneously extracting milk thistle oil and silymarin from milk thistle cake of the present embodiment is as follows:

[0052] (a) The cold-pressed silymarin cake is transported to the extractor by the material seal conveyor, and at a temperature of 50°C, successively passes through the extractor containing silymarin oil with a mass concentration of 16%, 14%, 10%, 6.0%, 3.0%, 1.6%, and 0.6% solvents are subjected to seven-stage spray soaking extraction, and then solvent spray soaking extraction to achieve multi-stage pulse countercurrent extraction. The extraction time is 120min, and extracts containing silymarin oil and silymarin mixed liquid, and the remaining milk thistle pulp;

[0053] Wherein, the solvent used in the extraction process is a mixed solvent of methanol and n-hexane with a mass ratio of 0.8:1, and the mass ratio of solvent to milk thistle cake is 1.2:1;

[0054] After extraction, the residual mass fraction of ...

Embodiment 3

[0062] Embodiment 3: The production method of simultaneously extracting milk thistle oil and silymarin from milk thistle cake of the present embodiment is as follows:

[0063](a) The cold-pressed milk thistle cake is transported to the extractor by the material seal conveyor, and at a temperature of 55°C, successively pass through the extractor containing milk thistle oil with a mass concentration of 16.5%, 14.5%, 11.0%, 7.0%, 3.5%, 2.0%, and 0.8% solvents are subjected to seven-stage spray soaking extraction, and then solvent spray soaking extraction to achieve multi-stage pulse countercurrent extraction. The extraction time is 180min, and extracts containing silymarin oil and silymarin mixed liquid, and the remaining milk thistle pulp;

[0064] Wherein, the solvent used in the extraction process is a mixed solvent of methanol and n-hexane with a mass ratio of 1:1, and the mass ratio of solvent to milk thistle cake is 1.0:1;

[0065] After extraction, the residual mass fract...

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Abstract

The invention discloses a production method for simultaneously extracting silybum marianum oil and silymarin from a silybum marianum cake. The method comprises the following steps: (a) performing multistage pulse counter-current extraction on the silybum marianum cake to obtain a mixed solution containing the silybum marianum oil and the silymarin, wherein the solvent used in the extracting process is a mixed solvent of the methanol and the normal hexane at a mass ratio of (0.6-1):1; (b) filtering and separating the mixed solution containing the silybum marianum oil and the silymarin to obtain the silybum marianum oil normal hexane mixed solution and the silymarin methanol mixed solution; (c) performing negative-pressure counter-current film evaporation and negative-pressure water vapor steam distillation on the silybum marianum oil normal hexane mixed solution to obtain the silybum marianum oil; and (d) performing negative-pressure climbing film evaporation, negative-pressure rectification and spray dehydration on the silymarin methanol mixed solution to obtain the silymarin. By adopting the method provided by the invention, the extracting rate of the silymarin is greatly increased and the problems of large input of the solvent and low extracting rate in the silymarin production process can be solved; the production process is free of pollution and low in cost, so that the large-scale, industrial and continuous production of the silymarin can be realized.

Description

technical field [0001] The invention relates to a production method for extracting and preparing chemical materials from agricultural resources, in particular to a method for simultaneously extracting milk thistle oil and silymarin from milk thistle cake. Background technique [0002] Silymarin (Silymarin) refers to a flavonoid lignan compound extracted from the seeds of the medicinal plant Silybum marianum. It is off-white or light yellow powder with bitter taste. The main active ingredients are 4 isomers of silybin, isosilybin, silycrystin and silydianin. Silymarin has been used to treat liver and gallbladder diseases for more than 2,000 years. Silymarin can prevent damage to the liver caused by chemical toxins, food toxins and drugs, and can promote the regeneration and repair of liver cells. It is known as a natural liver protection drug. Silymarin has the effect of resisting various poisons in the liver, stabilizing the liver cell membrane, and lowering blood lipids. ...

Claims

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Application Information

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IPC IPC(8): C11B1/10C07D407/04
Inventor 满时勇王晓平彭本林
Owner 安徽嘉旗粮油工程技术有限公司
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