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Method for determining contents of 18 kinds of volatile and semi-volatile organic compounds in electronic cigarette smoke liquid and aerosol

An electronic cigarette liquid, semi-volatile technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the adverse effects on human health, affect the safety of electronic cigarettes, and the weight of electronic cigarettes The composition of liquid and aerosol varies greatly. And other issues

Active Publication Date: 2015-05-27
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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Problems solved by technology

However, there are still few studies on the determination of harmful components in e-cigarette liquids and aerosols
[0003] E-cigarette liquid will bring some volatile and semi-volatile organic compounds through solvents, tobacco extracts, additives, etc., which are potentially harmful substances in e-cigarette aerosol One of the ingredients, volatile and semi-volatile organic compounds in e-cigarette liquid and aerosol will affect the safety of e-cigarettes and may have adverse effects on human health
At present, the method for determining volatile and semi-volatile organic compounds in traditional cigarette smoke is mainly gas chromatography-mass spectrometry (Han Bing et al. China Tobacco Journal, 2011, 17(4): 1-7.), however, compared to Traditional cigarettes and e-cigarettes vary greatly in terms of weight, filters, e-liquid and aerosol components, so it is necessary to establish a method for the determination of volatile and semi-volatile organic compounds in e-cigarette liquid and aerosol
However, there are few studies on volatile and semi-volatile organic compounds in e-cigarette aerosol (Goniewicz, M L, et al. Tobacco control, 2013, 0: 1-7.), while volatile and semi-volatile organic compounds in e-cigarette liquid The determination of organic matter has not been reported

Method used

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  • Method for determining contents of 18 kinds of volatile and semi-volatile organic compounds in electronic cigarette smoke liquid and aerosol
  • Method for determining contents of 18 kinds of volatile and semi-volatile organic compounds in electronic cigarette smoke liquid and aerosol
  • Method for determining contents of 18 kinds of volatile and semi-volatile organic compounds in electronic cigarette smoke liquid and aerosol

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Experimental program
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preparation example Construction

[0047] 2. Preparation of standard working solution

[0048] Accurately weigh about 500 mg of the standard substance of the compound to be tested in a 100 mL brown volumetric flask, dissolve it in methanol to obtain a mixed standard stock solution, and then accurately measure 0.05, 0.1, 0.2, 0.5, 1.0, 2.0 mL of mixed Put the standard stock solution in a 10 mL brown volumetric flask, add 0.1 mL internal standard stock solution (0.4 mg / mL benzene-d6 in methanol), and dilute to volume with methanol to obtain volatile and semi-volatile standards with 6 concentration gradients working solution.

[0049] 3. Sample pretreatment Ⅰ- smoke liquid

[0050] Accurately measure about 0.5-1.5 g of e-cigarette liquid into a 25 mL conical flask, add internal standard and 5-7 mL of methanol, extract with stopper shaking for 10 min, transfer to a 10 mL volumetric flask, and wash with methanol And constant volume. The extract was dehydrated by anhydrous magnesium sulfate desiccant, and then pas...

Embodiment 1

[0073] According to the above method, choose an electronic cigarette product A , smoked 250 puffs under the Canada Health Intense smoking mode, and measured the content of the compound to be tested in the smoke liquid and aerosol:

[0074] serial number name Smoke liquid (μg / g) Aerosol (μg) 1 Isoprene not detected not detected 2 Acrylonitrile not detected not detected 3 2-Methylfuran not detected not detected 4 2-butanone 4.120 0.890 5 ethyl acetate not detected not detected 6 Chloroform not detected not detected 7 Tetrahydrofuran not detected not detected 8 benzene 3.303 0.750 9 2,5-Dimethylfuran not detected not detected 10 toluene 2.99 0.860 11 Ethylbenzene 2.575 1.080 12 m-(p-)xylene 6.54 1.020 13 O-xylene 3.366 0.570 14 Styrene 2.622 0.450 15 D-limonene 7.459 1.280 16 Benzaldehyde 1.530 0.300 17 Cyclopentadiene ...

Embodiment 2

[0076] According to the above method, choose an electronic cigarette product B , smoked 250 puffs under the Canada Health Intense smoking mode, and measured the content of the compound to be tested in the smoke liquid and aerosol:

[0077] serial number name Smoke liquid (μg / g) Aerosol (μg) 1 Isoprene not detected not detected 2 Acrylonitrile not detected not detected 3 2-Methylfuran not detected not detected 4 2-butanone 2.640 0.820 5 ethyl acetate not detected not detected 6 Chloroform not detected not detected 7 Tetrahydrofuran not detected not detected 8 benzene 0.161 0.089 9 2,5-Dimethylfuran not detected not detected 10 toluene 0.102 0.024 11 Ethylbenzene not detected not detected 12 m-(p-)xylene 0.662 0.312 13 O-xylene 0.417 0.138 14 Styrene not detected not detected 15 D-limonene not detected not detected 16 Benz...

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Abstract

The invention relates to a method for determining contents of 18 kinds of volatile and semi-volatile organic compounds in electronic cigarette smoke liquid and aerosol. The method is characterized by comprising the following steps: extracting volatile and semi-volatile organic compounds in the smoke liquid by utilizing an oscillation extraction method and taking methanol as a solvent; smoking an electronic cigarette by utilizing a smoking machine with a conversion connecting device, and trapping the volatile and semi-volatile organic compounds in aerosol by using a Cambridge filter and a cold trap; extracting the volatile and semi volatile organic compounds on the filter by the oscillation extraction method, analyzing by utilizing a gas chromatography and a mass spectrometry detector, and quantifying by using an internal standard method. The method provided by the invention has the advantages that the sample pretreatment method of the analysis method is high in efficiency, is simple and effective, and is easy to operate, the linear relation of 18 kinds of volatile and semi-volatile organic compounds in the linear range is good, the standard addition recovery rate (95.1% -117.5%) is good, and the relative standard deviation is less than 6.30%. The method is especially suitable for determining the volatile and semi volatile organic compounds in the electronic cigarette.

Description

technical field [0001] The invention relates to the technical field of physical and chemical testing of electronic cigarette products, in particular to a method for measuring the content of 18 kinds of volatile and semi-volatile organic compounds in electronic cigarette liquid and aerosol. Background technique [0002] Electronic cigarette (electrical cigarette, e-cigarette), also known as electronic nicotine delivery system (electronic nicotine delivery systems, ENDS), is a new form of nicotine intake that looks similar to cigarettes. Over the years, e-cigarettes have used "health care", "quit smoking" and "cleaning the lungs" as their promotional slogans, with the Internet as the main marketing channel, and their sales in China have increased significantly. However, there are still few studies on the determination of harmful components in e-cigarette liquids and aerosols. [0003] E-cigarette liquid will bring in some volatile and semi-volatile organic compounds through s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
Inventor 韩书磊陈欢刘彤付亚宁任春雷侯宏卫胡清源
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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