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Safe biological sample pretreatment device and method integrating collection and processing

A biological sample and safety technology, applied in the direction of sampling device, test sample preparation, etc., can solve the problems of low accuracy of measurement results, cumbersome operation steps, hidden dangers to the health of operators, etc., and achieve the elimination of direct contact with pathogenic pathogenic microorganisms opportunities, improve safety, and reduce labor intensity

Active Publication Date: 2017-03-15
HEBEI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The second purpose of the present invention is to provide a safe pretreatment method for biological samples that integrates collection and processing, so as to solve the problems of health hazards, cumbersome operation steps and measurement problems that are easy to bring to operators during the analysis of biological samples in the prior art. The problem of relatively low accuracy of results

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  • Safe biological sample pretreatment device and method integrating collection and processing
  • Safe biological sample pretreatment device and method integrating collection and processing
  • Safe biological sample pretreatment device and method integrating collection and processing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1, a safe biological sample pretreatment device integrating collection and processing.

[0064] refer to Figure 1~Figure 3 The safe biological sample pretreatment device integrating collection and processing provided in this embodiment includes a main pipe 1 , a hollow fiber membrane 2 , a catheter 3 , a fixed plug 4 , an inner protective cap 5 and an outer protective cap 6 .

[0065] The main pipe 1 has a U-shaped structure, its outlet end (or called the opening end) faces upwards, and is placed vertically; a first rib 1-1 is provided on the outer wall of the main pipe 1 close to its outlet end. The hollow fiber membrane 2 is located in the main pipe 1 and parallel to the axis of the main pipe 1 . When the biological sample is whole blood, an anticoagulant (such as heparin or EDTA, etc., not shown in the figure) should be coated on the outer wall of the lower part of the hollow fiber membrane 2 and / or the inner wall of the lower part of the main pipe 1 . In ...

Embodiment 2

[0074] Example 2, a safe biological sample pretreatment method integrating collection and processing.

[0075] refer to Figure 1~Figure 3 , this embodiment includes the following steps:

[0076] a. Install a hollow fiber membrane 2 parallel to the axis of the main pipe 1 . For the case where the biological sample is whole blood, an anticoagulant should also be coated on the outer wall of the lower part of the hollow fiber membrane 2 and / or the inner wall of the lower part of the main pipe 1 .

[0077] b. Connect the conduit 3 at the outlet end of the hollow fiber membrane 2, and fix the conduit 3 with a fixed plug 4, which is also used to seal the outlet end of the main pipe 1; a first pass is opened on the fixed plug 4 Hole 4-1.

[0078] c. Pre-install the inner protective cap 5 on the outlet end of the main pipe 1. The inner protective cap 5 is an annular structure with an end cap; the end cap of the inner protective cap 5 is provided with a guide needle tube 5-1 facing...

Embodiment 3

[0086] Example 3, another safe biological sample pretreatment device integrating collection and processing.

[0087] Such as Figure 4~Figure 6 As shown, the integrated and safe biological sample pretreatment device provided in this embodiment includes a main pipe 1 , a hollow fiber membrane 2 , a catheter 3 , a movable plug 7 and a protective cap 8 .

[0088] In this embodiment, the structures of the main pipe 1, the hollow fiber membrane 2 and the conduit 3 are basically the same as those of the first embodiment, the difference is that the outer wall of the main pipe 1 is not provided with the first rib 1-1 in this embodiment, and the main pipe 1 A third rib 1-3 and a fourth rib 1-4 are sequentially arranged on the inner side wall of 1 near the outlet end, and the fourth rib 1-4 is located below the third rib 1-3. For other structures, reference may be made to Embodiment 1, which will not be repeated here.

[0089] The movable plug 7 is inserted into the main pipe 1 at the...

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Abstract

The invention provides a safe biological sample pretreatment device and method integrating collection and processing. The safe biological sample pretreatment device integrating collection and processing provided by the present invention includes a main pipe, a hollow fiber membrane, a catheter, a fixed plug (or a movable plug), an inner protective cap and an outer protective cap. The device is a fully enclosed device that integrates sampling, removal and separation of macromolecular substances. For the case where the sampled sample is whole blood, the use of this device can avoid the need for separation of plasma and removal of macromolecular substances such as protein. Operation, that is, the device uses the principle of ultrafiltration to directly obtain the filtrate containing only small molecular substances to be tested, while the dangerous pathogenic microorganisms contained in the whole blood sample are always in a fully enclosed negative pressure during the entire analysis process In the environment, there is no chance of exposure and transmission, which can ensure the health and safety of the operator; it can also reduce the operation steps and improve the accuracy and reliability of the test results.

Description

technical field [0001] The invention relates to a biological sample pretreatment device, in particular to a biological sample pretreatment device and method with integrated collection and processing safety. Background technique [0002] The analysis of small molecular substances in biological samples can most directly obtain accurate information about biological organisms. The analysis of drug biological samples has important functions and practical significance, such as in the monitoring of clinical therapeutic drugs, in the detection of drug abuse, drug use, drivers taking prohibited drugs and athletes taking doping drugs, as well as in the public security and judicial departments. In processes such as forensic poison analysis, drug (or poison) analysis can provide the most powerful evidence for identification results to some extent. [0003] Plasma is the most commonly used test material in biological sample drug analysis. The plasma obtained by centrifugation of whole b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/10G01N1/34
Inventor 蒋晔张金凤杜朝辉
Owner HEBEI MEDICAL UNIVERSITY
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