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Application of LMWH (low-molecular weight heparin) in preparation of medicine for treating itch

A low-molecular-weight heparin and low-molecular-weight heparin technology, applied in the field of medicine, can solve the problem of low-molecular-weight heparin's lack of literature reports

Inactive Publication Date: 2015-05-13
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no literature report on the role of low molecular weight heparin in anti-itching

Method used

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  • Application of LMWH (low-molecular weight heparin) in preparation of medicine for treating itch
  • Application of LMWH (low-molecular weight heparin) in preparation of medicine for treating itch
  • Application of LMWH (low-molecular weight heparin) in preparation of medicine for treating itch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1: Low molecular weight heparin gel formulation optimization

[0058] 1. Experimental method

[0059] 1.1 Determination of LMWH content

[0060] Use the Azure A method to detect the content of LMWH dissolved in PBS, mix 100 μl low molecular weight heparin standard PBS solution with 900 μl Azure A solution (0.01 mg / ml), there is a maximum absorption value at 530nm wavelength, use a UV spectrophotometer Check absorbance. Low molecular weight heparin has a good linear relationship in the concentration range of 5-30μg / ml, Y=0.0019x+0.0039(R 2 =0.9981, n=3).

[0061] 1.2 Preparation method of LMWH gel

[0062] Weigh Carbomer 940, add a small amount of water to swell overnight at room temperature, add triethanolamine dropwise to make a gel between pH 6-8; weigh low molecular weight heparin, and azone dissolved in 1.5ml absolute ethanol , respectively poured into the above gel, add water to 10g, stir well and set aside.

[0063] 1.3 In vitro transdermal permeatio...

Embodiment 2

[0092] Embodiment 2: Experiment of low molecular weight heparin gel in pruritus model

[0093] 1. Experimental method

[0094] 1.1 Preparation, grouping and administration of pruritus model

[0095]BALB / c mice were bred for one week to acclimate to the environment. 24 hours before the experiment, the mice were depilated with depilatory cream on the neck and back, and 0.1g LMWH gel was given to the depilated site for three consecutive days, twice a day. After the last administration, the mice were moved to the observation box for 2 hours to adapt to the environment. The drug was quickly injected intradermally on the back of the neck of the mouse, and placed in an observation box to record the scratching behavior of the mouse with a shooting time of 1 hour. The experiment was divided into normal control group (50μl normal saline), model group (100nmol SLIGRL-NH 2 / 50μl), low molecular weight heparin gel group (100nmol SLIGRL-NH 2 / 50μl), compound dexamethasone acetate cream ...

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Abstract

The invention relates to the technical field of medicine, provides an application of LMWH (low-molecular weight heparin) in preparation of medicine for treating itch, and further provides an LMWH gel preparation. An animal itch model proves that the gel preparation has an anti-itching function superior to compound dexamethasone acetate cream. The novel medical application of LMWH is developed, and a novel treatment means is provided for clinical anti-itching treatment.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new medical application of low-molecular-weight heparin. Background technique [0002] Atopic dermatitis is a chronic, relapsing, inflammatory skin disease that can occur at any age, mainly in children, especially in infancy, and is one of the common diseases that affect children's growth and mental health (see literature 1.Yosipovitch G, Greaves MW, Schmelz M[J].Itch.Lancet,2003,361:690-694.; 2.Twycross R,Greaves MW,Handwerker H,et al.Itch:scratching more than the surface[J] ]. QJM, 2003, 96:7-26.). The clinical manifestation of patients with atopic dermatitis is mainly severe itching, which is often aggravated at night, and the degree of itching is closely related to the severity of the disease. At present, there is still no specific method for the treatment of atopic dermatitis. The main clinical treatments are corticosteroids, immune regulation and local UV irradiation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/727A61K9/06A61P17/04
Inventor 胡晋红李超
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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