Method for detecting compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy
A technology of dexamethasone acetate and near-infrared spectroscopy, applied in measuring devices, material analysis through optical means, instruments, etc., can solve problems such as complex pre-processing operations and difficulty in online detection, and achieve simple operation and good stability , Real-time monitoring of the effect of concentration changes
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Embodiment 1
[0039] This embodiment provides a method for online detection of the content of dexamethasone acetate in compound dexamethasone acetate cream by using near-infrared spectroscopy. The detection steps are as follows:
[0040] (1) Use a near-infrared spectrometer to collect the near-infrared spectrograms of 60 compound dexamethasone acetate cream standard products online, and select the corresponding wavenumber range of dexamethasone acetate to be 10000-4000cm -1 Spectral band of the spectral waveband is used as characteristic spectrum, carries out first-order differential and Norris smoothing preprocessing to described characteristic spectrum, obtains the near-infrared spectrogram after preprocessing (see figure 1 ), the calculation formula of the first-order differential and Norris smoothing pretreatment is as follows:
[0041] dy dx + P ( x ) y = ...
Embodiment 2
[0060] The present embodiment provides a method for online detection of menthol and camphor content in compound dexamethasone acetate cream by using near-infrared spectroscopy, and the detection steps are as follows:
[0061] (1) Collect the near-infrared spectra of 80 compound dexamethasone acetate cream standard products online with a near-infrared spectrometer, and select menthol and camphor to correspond to a wavenumber range of 10000-4000cm -1 Spectral band of the spectral waveband is used as characteristic spectrum, carries out first-order differential and Norris smoothing preprocessing to described characteristic spectrum, obtains the near-infrared spectrogram after preprocessing (see figure 1 ), the calculation formula of the first-order differential and Norris smoothing pretreatment is as follows:
[0062] dy dx + P ( x ) y = Q ...
Embodiment 3
[0093] The present invention also provides a system for on-line detection of compound dexamethasone acetate cream, such as Figure 7 As shown, it includes a cream-making tank for preparing the cream, a storage tank for storing the finished cream product, and a near-infrared spectrometer; wherein, the cream-making tank and the cream storage tank are connected by a connecting pipe, and A sampling port for the fiber probe of the near-infrared spectrometer to sample and collect data is provided on the connecting pipe at a position 1 / 3-2 / 3 of the length of the connecting pipe from the paste outlet, and preferably the sampling port is located in the The location of the center point of the connecting pipe.
[0094]The inner diameter of the sampling port is 15-18mm, and preferably 16.1nm.
[0095] It should be noted that since near-infrared spectroscopy acquires spectral data through multiple scans in a short period of time, there are relatively strict requirements on the properties ...
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