Preparation method and application of guanidinoacetic acid complex

A technology of guanidinoacetic acid and complexes, which is applied in the field of feed additive preparation, can solve the potential value and impact of animal feeding is immeasurable, affect energy utilization efficiency and other issues, to avoid environmental pollution and sewage treatment burden, improve absorption and utilization efficiency and reduce environmental pollution

Active Publication Date: 2018-02-27
XINGJIA BIO ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Guanidinoacetic acid mainly participates in energy metabolism in animals, while trace elements such as iron, zinc, copper, chromium, etc. also participate in and affect energy metabolism and affect energy utilization efficiency. Therefore, these two types of substances that have a great impact on energy metabolism Formation of complexes by means of chemical synthesis may have an important impact on the energy metabolism and physiological functions of animals, and the potential value and impact on animal feeding are immeasurable

Method used

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  • Preparation method and application of guanidinoacetic acid complex
  • Preparation method and application of guanidinoacetic acid complex
  • Preparation method and application of guanidinoacetic acid complex

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Embodiment 1: the preparation of zinc guanidine acetate

[0053] A preparation method for the zinc guanidine acetate complex used as an animal feed additive, comprising the following steps:

[0054] Add 300Kg of mother liquor into the jacketed reaction kettle, open the stirring device and steam valve, heat to the reaction temperature of 50°C, add 182Kg of zinc sulfate monohydrate (purity: 98%), continue stirring for 15min until the materials are completely dissolved, and then add 246Kg guanidinoacetic acid (purity: 99%), slowly adjust the pH value of the reaction system with 5% concentration of sodium hydroxide solution to be 8.2, heat up to 40°C and stir for 30min, until the reaction is complete, close the steam valve, and pass through the jacket. into the ground water and cooled to 30°C for crystallization. After the crystallization is completed, discharge and press filter, and flash dry to obtain 272Kg of zinc guanidinoacetate in the solid phase. The next batch of r...

Embodiment 2

[0056] Embodiment 2: the preparation of zinc guanidine acetate

[0057] A preparation method for the zinc guanidine acetate complex used as an animal feed additive, comprising the following steps:

[0058] Add 500Kg of water into the jacketed reaction kettle, open the stirring device and steam valve, heat to the reaction temperature of 70°C, add 211Kg of zinc oxide (purity: 96%), continue stirring for 15min until the material is completely dissolved, and then add 603Kg of guanidine Glycoacetic acid (purity: 99%), heated up to 80°C and stirred for 2 hours. The pH value of the reaction system was 8.6. After the reaction was complete, the steam valve was closed, and ground water was passed into the jacket to cool to 30°C for crystallization. After the crystallization was completed, the The material was press-filtered and flash-dried to obtain 731Kg of zinc guanidinoacetate as a solid phase substance, and the liquid phase was used as the initial mother liquor of the next reaction ...

Embodiment 3

[0060] Embodiment 3: the preparation of guanidine copper acetate

[0061] A preparation method for a guanidine copper acetate complex as an animal feed additive, comprising the following steps:

[0062] Add 300g of the mother liquor of the previous batch of reactions to a 500ml beaker and place it in a 75°C constant temperature water bath, turn on the stirring device, weigh 118g of guanidinoacetic acid (purity: 99%), continue to stir for 10min, and then add 117g of basic chlorination Copper (purity: 99%), slowly adjust the pH value of the reaction system to 10.5 with potassium hydroxide with a concentration of 8%, continue to slowly stir the reaction in a 70°C water bath for 40min, until the reaction is complete, turn off the power supply of the constant temperature water bath, and cool down naturally , the reaction system was naturally cooled and crystallized in a water bath. When the temperature was cooled to 25°C, the beaker was taken out to filter the reaction product. Aft...

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Abstract

A preparation method of a guanidinoacetic acid complex, first adding guanidinoacetic acid and trace element source substances for animals into a reaction system, reacting in a weakly alkaline environment, and controlling the molar ratio of guanidinoacetic acid to trace elements as 1.8~3.5:1; After the reaction is complete, the reaction system is crystallized, and then solid-liquid separation is performed to obtain a solid phase and a liquid phase; the solid phase material is washed and dried to obtain a guanidinoacetic acid complex. The guanidinoacetic acid complex obtained by the method of the present invention can be applied as a feed additive product, and the guanidinoacetic acid complex includes copper guanidinoacetate, ferrous guanidinoacetate, zinc guanidinoacetate, manganese guanidinoacetate, chromium guanidinoacetate One or more of them can be added in different amounts according to different feeding objects. The method of the invention has simple process steps, low process cost, easy operation, no discharge or clean discharge, and meets feed hygiene standards.

Description

technical field [0001] The invention relates to a preparation method of a feed additive and related products, in particular to a preparation method of a feed additive guanidinoacetic acid complex and a product thereof. Background technique [0002] Guanidine acetic acid is also known as guanidine acetic acid (guanidine acetic acid, L) and N-imidyl glycine, molecular formula C 3 h 7 N 3 o 2 , with a molecular weight of 117ku, colorless leaf-like or needle-like crystals, soluble in water, very slightly soluble in ethanol and ether, guanidinoacetic acid was first isolated from human and dog urine by Weber, and proposed guanidinoacetic acid It is a precursor of creatine, an intermediate product of metabolism and excreted in urine, but the formation mechanism of guanidinoacetic acid has not been studied in depth. [0003] Guanidinoacetic acid is formed from glycine and L-arginine in animals, that is, the guanidino bond of L-arginine is cut by L-arginine glycine imidyl transfe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K20/20
Inventor 黄逸强
Owner XINGJIA BIO ENG CO LTD
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