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Method used for detecting multiple trace drug pollutants in drinking water simultaneously

A technology for drinking water and pollutants, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of unfavorable PPCPs pollution, single type of detection target substances, unsuitable PPCPs detection, etc., and achieves strong selectivity and simple operation. , the effect of high sensitivity

Inactive Publication Date: 2015-04-22
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the current detection methods for PPCPs in the water environment have high detection limits, which are not suitable for the detection of trace concentration levels of PPCPs in drinking water
In addition, most other PPCPs detection methods focus on the detection of a certain type of substance, and the detection target substance is single and small in number, which is not conducive to a comprehensive understanding of the pollution status of PPCPs in drinking water

Method used

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  • Method used for detecting multiple trace drug pollutants in drinking water simultaneously
  • Method used for detecting multiple trace drug pollutants in drinking water simultaneously
  • Method used for detecting multiple trace drug pollutants in drinking water simultaneously

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] (1) Take 1000mL ultrapure water, add 50μL 2mg / L PPCPs mixed standard solution, mix well and add 0.5g Na 2 EDTA, using hydrochloric acid to adjust the pH of the water sample to 2.

[0062] (2) Solid phase extraction

[0063] Sequentially use 6mL chromatographically pure methanol, 6mL 0.25g / L Na 2 EDTA aqueous solution and 6mL ultrapure water were used to activate the HLB solid-phase extraction column, and the solid-phase extraction was carried out at a flow rate of 5mL / min. After the water sample completely passed through, 6mL ultrapure water was added to the solid-phase extraction column to rinse the column. Wash; suck and dry the solid-phase extraction column in the air for 30min, use 10mL methanol to elute the HLB solid-phase extraction column under gravity conditions, and collect the eluate in a 10mL round-bottomed glass tube. Nitrogen was blown to near dryness in a water bath at 40°C, and the initial ratio mobile phase [10% acetonitrile / formic acid water (containi...

Embodiment 2

[0071] Get the 1000mL tap water sample of a water supply pipe network of a waterworks in Tianjin, through the membrane negative pressure suction filtration of 0.2 μm, detection procedure is identical with embodiment 1, and detection result is shown in Table 2 (ibuprofen and ketoprofen without checkout).

[0072] Table 2 (ng / L)

[0073] compound

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Abstract

The invention discloses a method used for detecting multiple trace drug pollutants in drinking water simultaneously. A water sample membrane is filtered first, Na2EDTA is added, and the pH of a water sample is adjusted; solid-phase extraction is conducted through methyl alcohol, a Na2EDTA solution and ultrapure water activated HLB in sequence to obtain a column, column chromatography is conducted on the water sample, the column is pumped for a half hour to be dried, the solid-phase extraction column is eluted through methyl alcohol under the gravity condition, a termovap sample concentrator is used for blowing an eluant dry, and a solution proportional to an initial mobile phase is added to dissolve residues; a high performance liquid chromatograph mass spectrometer is used for quantitatively detecting target substances of drugs( namely PPCPs). Various target substances are detected, a pretreatment method is easy to operate, environmentally friendly and high in concentration multiple, and the method is good in reproducibility. The method has the advantages that the application range is wide, sensitivity is high, and various substances are detected.

Description

technical field [0001] The invention relates to a detection method for water environment pollutants, in particular to a detection method for simultaneously detecting 7 kinds of trace drugs and personal care products (PPCPs) in drinking water, that is, for trace amounts of ibuprofen, ketone-based Methods for the detection of ibuprofen, nadolol, bezafibrate, diltiazem, daxopin, and fluoxetine. Background technique [0002] Pharmaceuticals and personal care products (PPCPs) are a class of compounds closely related to people's daily life, mainly including human medicines and veterinary medicines and other chemical consumer products such as cosmetics and musk substances, and also used in the production and processing of medicines and care products Additives and inert ingredients, etc., the more common ones include various types of drugs used in large quantities, such as antibiotics used for antibacterial and sterilization, anti-inflammatory and pain-relieving drugs, epilepsy drug...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/06
Inventor 张练肖敏如吴卿李楠赵新华
Owner TIANJIN UNIV
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