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Rhizoma acori graminei volatile oil fast-disintegrating oral tablet and preparation method thereof

A technology of oral fast disintegrating tablets and volatile oil, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of esophagus obstruction, tissue damage, gastric and gastrointestinal bleeding, and slow disintegration, etc. To achieve the effect of reducing irritation, convenient swallowing, convenient transportation and storage

Active Publication Date: 2015-03-25
HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. It is safe to take. Ordinary tablets disintegrate slowly, and in the process of oral administration, it is easy to cause the risk of esophageal obstruction and tissue damage, while irritating drugs such as aspirin, potassium chloride, garlic oil, etc., due to their ingestion in the stomach Excessive local concentration can easily induce gastric and gastrointestinal bleeding

Method used

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  • Rhizoma acori graminei volatile oil fast-disintegrating oral tablet and preparation method thereof
  • Rhizoma acori graminei volatile oil fast-disintegrating oral tablet and preparation method thereof
  • Rhizoma acori graminei volatile oil fast-disintegrating oral tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The formula of Shichangpu volatile oil orally disintegrating tablets is as follows:

[0023]

[0024] To prepare, follow these steps:

[0025] 1) Preparation of the β-cyclodextrin inclusion compound of the volatile oil of Acorus calamus: add 5 times the amount of water to the β-cyclodextrin according to the formula ratio and thoroughly grind until the solution becomes a paste, then add the volatile oil of Acorus calamus in the Mix well in a colloid mill, grind into a paste, refrigerate at 4°C for 12 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the β-cyclodextrin inclusion complex of volatile oil of Acorus calamus in white powder form;

[0026] 2) Powder direct tableting: Weigh the β-cyclodextrin inclusion complex of Acorus volatile oil and other components according to the formula ratio, fully mix, pass through a 100-mesh sieve, put the mixed powder into a tablet machine for direct tableting.

Embodiment 2

[0028] The formula of Shichangpu volatile oil orally disintegrating tablets is as follows:

[0029]

[0030] To prepare, follow these steps:

[0031] 1) Preparation of β-cyclodextrin inclusion compound of volatile oil of Acorus acorus: according to the formula ratio, add 5 times the amount of water to β-cyclodextrin and grind thoroughly to make the solution into a paste, then add volatile oil of Acorus acorus in Mix well in a colloid mill, grind into a paste, refrigerate at 4°C for 12 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the β-cyclodextrin inclusion complex of volatile oil of Acorus calamus in white powder form;

[0032] 2) Wet granulation and tabletting: Weigh the β-cyclodextrin inclusion complex of Acorus volatile oil and other components according to the formula ratio, mix them well, and pass through a 100-mesh sieve, add an appropriate amount of 60% ethanol to prepare a soft material, pass through Granulate with a 20-mes...

Embodiment 3

[0034] The formula of Shichangpu volatile oil orally disintegrating tablets is as follows:

[0035]

[0036]

[0037] To prepare, follow these steps:

[0038] 1) Preparation of β-cyclodextrin inclusion compound of volatile oil of Acorus acorus: according to the formula ratio, add 5 times the amount of water to β-cyclodextrin and grind thoroughly to make the solution into a paste, then add volatile oil of Acorus acorus in Mix well in a colloid mill, grind into a paste, refrigerate at 4°C for 12 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the β-cyclodextrin inclusion complex of volatile oil of Acorus calamus in white powder form;

[0039] 2) Wet granulation and tabletting method: fully mix the β-cyclodextrin inclusion compound of Acorus volatile oil and the remaining auxiliary materials except magnesium stearate and 1 / 2 low-substituted hydroxymethylcellulose, and pass through 100 mesh Sieve, add appropriate amount of distilled wat...

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Abstract

The invention discloses a rhizoma acori graminei volatile oil fast-disintegrating oral tablet and a preparation method thereof. The rhizoma acori graminei volatile oil fast-disintegrating oral tablet is prepared by taking 1.2-3.5 percent of rhizoma acori graminei volatile oil by weight, 8-15 percent of a flavoring agent by weight, 55-75 percent of a filling agent by weight, 5-7 percent of a disintegrating agent by weight, 1-4 percent of a flow aid by weight and 0.15-0.8 percent of a lubricating agent by weight as materials, adopting a beta-cyclodextrin camplexation technique and a powder direct tabletting method or a wet process granulating and tabletting method and pressing by the utilization of a tabletting machine. Compared with the prior art, the rhizoma acori graminei volatile oil fast-disintegrating oral tablet and the preparation method thereof have the benefits that beta-cyclodextrin camplexation powder wrapped with the rhizoma acori graminei volatile oil and other auxiliary materials are mixed and directly tabletted into the fast-disintegrating oral tablet; after being placed in an oral cavity, the fast-disintegrating oral tablet is mixed with saliva to be swallowed by a patient, so that the objectionable odor of the rhizoma acori graminei volatile oil is masked, the stimulation to gastrointestinal tracts is also reduced, and meanwhile, the treatment effect of the rhizoma acori graminei volatile oil is also not affected; the swallowing is convenient for infants and middle and old aged patients, transportation and storage are facilitated, and the market prospect is wide.

Description

technical field [0001] The invention relates to the technical field of oral solid preparations, in particular to an orally disintegrating tablet of Shichangpu volatile oil and a preparation method thereof. Background technique [0002] Shichangpu is listed as the top grade in "Shen Nong's Materia Medica". It is a traditional aromatic medicine that has the effects of resuscitating phlegm, refreshing and improving intelligence. The main active ingredient is the volatile oil of Shichangpu, including β-asarone, α-asarone and other substances. However, the physical properties of these components are unstable and easily oxidized, resulting in a decrease in the efficacy of the drug. The market dosage form of Shichangpu volatile oil is Shichangpu volatile oil injection, but due to the side effects and high risk of direct injection of this injection into the human body, it has been removed from the shelves. [0003] Orally rapidly disintegrating tablets are new oral solid preparati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K36/888A61P25/28
Inventor 赵蕊贾桂燕蔡亚平赵辉邵星月
Owner HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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