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Bidirectional transition luminescent material and preparation method thereof

A luminescent material, bidirectional conversion technology, applied in luminescent materials, chemical instruments and methods, wave energy or particle radiation treatment materials, etc., to achieve the effects of good biocompatibility, clear imaging, and strong conversion fluorescence performance

Inactive Publication Date: 2015-03-11
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional up-conversion luminescent materials are all doped with rare earth metals, and mainly fluorides and oxyfluorides, so their biological safety is still a hot and difficult research point.
At the same time, general down-conversion luminescent materials do not have the performance of up-conversion

Method used

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  • Bidirectional transition luminescent material and preparation method thereof
  • Bidirectional transition luminescent material and preparation method thereof
  • Bidirectional transition luminescent material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment one, it comprises the following steps:

[0026] 1) Dissolve 1ml of allyl acrylate and 1ml of ethyl diazoacetate in 50ml of toluene, and stir at room temperature for 16 hours.

[0027] 2) Nitrogen gas was passed through the reacted solution for one hour, and heated to 70° C., then 5 mg of azobisisobutyronitrile was added, and reacted at 70° C. for 12 hours.

[0028] 3) The reacted solution was separated by column chromatography to obtain a polymer having a pyrazoline group in the side chain, which was dissolved in ethyl acetate to prepare a 1 mg / ml solution, and its fluorescence spectrum was measured.

Embodiment 2

[0029] Embodiment two, it comprises the following steps:

[0030] 1) Add 0.12 g of menthyl diazoacetate and 0.03 ml of acrylonitrile into 10 ml of chloroform, and stir at room temperature for 16 hours.

[0031] 2) After the solution after the reaction is rotary evaporated, the pyrazoline monomer containing menthol group is obtained by column chromatography separation

[0032] 3) The pyrazoline monomer in step 2 was dissolved in dimethyl sulfoxide to prepare a 7 mg / ml solution, and its fluorescence spectrum was measured.

Embodiment 3

[0033] Embodiment three, it comprises the following steps:

[0034] 1) Add 0.5 g of ethyl diazoacetate and 0.3 g of acrylonitrile into 10 ml of chloroform, and stir at room temperature for 16 hours.

[0035] 2) After the solution after the reaction is rotary evaporated, the pyrazoline monomer containing cyano group is obtained by column chromatography separation

[0036] 3) The pyrazoline monomer in step 2 was dissolved in dimethyl sulfoxide to prepare a solution of 8 mg / ml, and its fluorescence spectrum was measured.

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Abstract

The invention discloses a bidirectional transition luminescent material and a preparation method thereof. Diazoacetate and alkene of which double bonds connected to an electrophilic group undergo 1,3-dipolar cycloaddition reaction to produce the bidirectional transition luminescent material. The bidirectional transition luminescent material is a polymer of which the side chain is connected to a pyrazoline group with fluorescence performances or a pyrazoline monomer contains other groups so that the material has special bidirectional transition luminescence performances. The bidirectional transition luminescent material can emit fluorescence with the same wavelength, can image in organisms under the actions of near infrared excitation and near ultraviolet excitation, can produce dual wavelength-excited fluorescence with intensity higher than that of fluorescence produced by single wavelength excitation and can further improve fluorescence imaging sharpness.

Description

technical field [0001] The invention relates to a class of luminescent materials and a preparation method thereof, in particular to a bidirectional conversion luminescent material containing pyrazoline and a preparation method thereof, belonging to the technical field of luminescent materials. Background technique [0002] Up-conversion luminescent material is a new type of fluorescent material that absorbs long-wavelength and low-energy photons and emits short-wavelength high-energy photons. It has excellent optical stability and high chemical stability, and has tissue penetration ability under near-infrared light excitation. Deep, no damage to biological tissue, almost zero background fluorescence interference, high imaging sensitivity and many other advantages, so it has a wide range of application prospects in biomedicine. However, the traditional up-conversion luminescent materials are all doped with rare earth metals, mainly fluorides and oxyfluorides, so their biologi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06C07D231/06C07D231/08A61K49/00A61K41/00A61P35/00
Inventor 刘立建陈诚李焰贾响响陈芳娟
Owner WUHAN UNIV
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