Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Olmesartan medoxomil tablet and preparation technology thereof

A technology for the preparation of olmesartan medoxomil, which is applied in the field of drug preparation, can solve problems such as unfavorable industrialization, high production cost, complex process, etc., and achieve cost reduction and labor intensity, time and energy saving, and simple production process Effect

Active Publication Date: 2015-03-11
SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
View PDF7 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent document CN102119930A discloses a kind of olmesartan medoxomil tablet and its preparation method. The auxiliary materials include lactose, microcrystalline cellulose, PVPK30, low-substituted hydroxypropyl cellulose, magnesium stearate and an appropriate amount of ethanol-water. In the method, the drug and lactose need to be ground, which makes the process complicated and poor in controllability
Patent document CN103040777A discloses a liposome solid preparation of olmesartan medoxomil and its preparation method. The stability of the drug is improved by combining olmesartan medoxomil with specific adjuvants into liposomes. The preparation method is very complicated. Moreover, the production cycle is long and the production cost is high, which is not conducive to industrialization
Patent document CN102028663A discloses a preparation method of a stable olmesartan medoxomil solid preparation, which reduces the degradation of olmesartan medoxomil by adding a pH regulator and a stabilizer. The preparation method adopts wet granulation, although absolute ethanol is used instead of Water is used to prevent the hydrolysis of active ingredients, but this method uses organic solvents in the granulation process, which brings great safety hazards to the production process, and the residual amount of organic solvents also needs to be strictly controlled, which makes the production cost high and labor-intensive

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Olmesartan medoxomil tablet and preparation technology thereof
  • Olmesartan medoxomil tablet and preparation technology thereof
  • Olmesartan medoxomil tablet and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A kind of preparation technology of olmesartan medoxomil tablet, comprises steps as follows:

[0047] (1) Selection of tablet core raw materials: the tablet core is composed of olmesartan medoxomil and pharmaceutical excipients, the pharmaceutical excipients include fillers, disintegrants and lubricants, and the weight ratio composition of raw materials in the tablet core is shown in Table 1;

[0048] (2) Raw material pulverization: olmesartan medoxomil is pulverized by airflow pulverization, and the particle size at 90% cumulative volume is controlled at 1-100 microns;

[0049](3) Mixing: mixing the pulverized olmesartan medoxomil with the filler and disintegrant in the pharmaceutical adjuvant, and finally adding lubricant and mixing;

[0050] (4) Compress the mixed raw materials into tablets according to the particle content;

[0051] (5) Coating.

Embodiment 2

[0053] A kind of preparation technology of olmesartan medoxomil tablet, step is the same as embodiment 1, and the weight ratio composition of raw material in tablet core is shown in Table 1.

Embodiment 3

[0055] A kind of preparation technology of olmesartan medoxomil tablet, comprises steps as follows:

[0056] (1) Selection of tablet core raw materials: the tablet core is composed of olmesartan medoxomil and pharmaceutical excipients, the pharmaceutical excipients include fillers, disintegrants and lubricants, and the weight ratio composition of raw materials in the tablet core is shown in Table 1;

[0057] (2) Raw material pulverization: olmesartan medoxomil is pulverized by airflow pulverization, and the particle size at 90% cumulative volume is controlled to be less than 30 microns;

[0058] (3) Mixing: first mix the pulverized olmesartan medoxomil with lactose, then add microcrystalline cellulose, low-substituted hydroxypropyl cellulose and mix, and finally add lubricant and mix;

[0059] (4) Compress the mixed raw materials into tablets according to the particle content;

[0060] (5) Coating.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to an Olmesartan medoxomil tablet and preparation technology thereof. The core of the Olmesartan medoxomil tablet is prepared by directly pressing Olmesartan medoxomil and medicinal assistants, and the particle size of a position accumulating 90% of Olmesartan medoxomil is 1-100[mu]m; and the medicinal assistants comprise a filler, a disintegrating agent and a lubricant, wherein the lubricant is one or more of neutral or inert lubricants. Raw materials of the core of the tablet comprise, by weight, 20 parts of Olmesartan medoxomil, 80-180 parts of the filler, 10-20 parts of the disintegrating agent and 2-10 parts of the lubricant. The Olmesartan medoxomil is crushed in an airflow crushing mode, the particle size is controlled, and the preparation technology adopts a direct powder pressing method, so the introduction of water in a wet granulation process and the degradation of active substances in a wet particle drying process are avoided, and the incidence of a hydrolysis reaction is prevented. The Olmesartan medoxomil tablet has the advantages of stability, good dissolution and simple preparation.

Description

technical field [0001] The invention relates to an olmesartan medoxomil tablet and a preparation process thereof, belonging to the technical field of medicine preparation. Background technique [0002] There are some reports about olmesartan medoxomil preparation technology in the prior art. For example, patent document CN101478966A discloses a pharmaceutical preparation containing olmesartan medoxomil and its preparation method with improved elution properties, wherein in addition to containing olmesartan medoxomil, it also contains suitable excipients and adjuvants thereof, so The excipients and adjuvants are selected from disintegrants, diluents, lubricants, binders, emulsifiers, flavoring agents and suitable active agents. This method adopts a high-pressure compression method, which consumes a lot of energy and has high requirements on the performance of the equipment. Patent document CN102119930A discloses a kind of olmesartan medoxomil tablet and its preparation meth...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/4178A61K47/12A61K47/14A61K47/44A61K47/26A61K47/38
Inventor 孔凡强吕义强卢伟伸周振宇王海青
Owner SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products