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Method and application of rapid detection of Uncaria medicinal materials by near-infrared spectroscopy

A near-infrared spectroscopy and near-infrared spectroscopy technology, applied in the field of medical testing, can solve the problems of not being able to adapt to the modern development of traditional Chinese medicine preparations, not reflecting the complexity of Chinese medicine ingredients, and difficult production practices, so as to improve production efficiency and economic benefits, shorten The effect of high detection time and high accuracy

Active Publication Date: 2017-10-13
CHINA RESOURCES SANJIU MEDICAL & PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the traditional quality detection method of Uncaria uncaria is time-consuming and laborious, and it is difficult to be widely used in production practice. It cannot meet the needs of the modern development of traditional Chinese medicine preparations, and often uses a single index component to control the quality of medicinal materials, which cannot reflect the complexity of traditional Chinese medicine ingredients. Therefore, there is an urgent need for a fast and comprehensive method for detecting Uncaria medicinal materials to meet the requirements of screening and quality control of large quantities of Uncaria medicinal materials

Method used

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  • Method and application of rapid detection of Uncaria medicinal materials by near-infrared spectroscopy
  • Method and application of rapid detection of Uncaria medicinal materials by near-infrared spectroscopy
  • Method and application of rapid detection of Uncaria medicinal materials by near-infrared spectroscopy

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Experimental program
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Effect test

Embodiment 1

[0058] A. Determination of moisture content includes the following steps:

[0059] (1) After selecting a total of 110 parts of Uncaria medicinal materials from different origins with known moisture content and pulverizing them, pass through an 80-mesh sieve to obtain Uncaria medicinal material powder with a relatively uniform particle size for subsequent use; wherein the Uncaria medicinal material powder is dried according to Method is used to measure the moisture content of the described Uncaria medicinal material, and obtain the standard content of the moisture of the described Uncaria medicinal material, the specific steps are as follows:

[0060] The moisture determination of Uncaria medicinal material is according to the drying weighing method recorded in the 2010 edition of "Chinese Pharmacopoeia", and the flat bottle (X 0 ), get the described Uncaria medicinal material powder of 2g, accurately weigh (X 1 ), baked in a vacuum oven at 105°C for 5 hours, took it out and c...

Embodiment 2

[0071] B. The determination of extract content includes the following steps:

[0072] (1) A total of 110 parts of Uncaria medicinal materials from different origins with known extract content were selected and pulverized, and passed through an 80-mesh sieve to obtain Uncaria medicinal material powder with a relatively uniform particle size, which was set aside; wherein the Uncaria medicinal material powder was heated according to Determination of the content of the extract of the Uncaria medicinal material by immersion method to obtain the standard content of the water extract of the Uncaria medicinal material, the specific steps are as follows:

[0073]Get described Uncaria medical material powder 1g, accurately weighed (X 1 ), placed in a 100mL Erlenmeyer flask, precisely added 25mL of ethanol, sealed tightly, weighed, allowed to stand for 1h and then ultrasonically extracted for 1h. After cooling down, weigh again, make up for the lost weight with ethanol, shake well, plac...

Embodiment 3

[0084] C, the mensuration of rhynchophylline content comprises the following steps:

[0085] (1) After selecting a total of 110 parts of Uncaria medicinal materials from different origins with known moisture content and pulverizing them, pass through an 80-mesh sieve to obtain Uncaria medicinal powder with a relatively uniform particle size, and set aside; The content of the rhynchophylline of the described Uncaria medicinal material is determined by phase chromatography, and the standard content of the rhynchophylline of the described Uncaria medicinal material is obtained, and the specific steps are as follows:

[0086] a. The preprocessing method is:

[0087] Take about 2 g of the Uncaria medicinal material powder, weigh it accurately, add 25 mL of methanol with a mass concentration of 75% precisely, put it in a refrigerator at 4°C for 2 hours, extract it ultrasonically for 60 minutes, use 75% methanol to make up for the weight loss, and then transfer the extract Centrifug...

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Abstract

The invention belongs to the technical field of medical detection, and in particular relates to a method and application for rapidly detecting Uncaria medicinal materials by using near-infrared spectroscopy, comprising the following steps: (1) selecting known water, extracts, rhynchophylline and isorhynchophylline (2) collect the near-infrared spectral data of Uncaria medicinal powder; (3) select the spectral information under the characteristic wave band and the known moisture content, leaching Correlate with the contents of rhynchophylline, rhynchophylline and isorhynchophylline, and use the partial least squares method to establish a quantitative calibration model; (4) carry out near-infrared spectrum scanning on unknown uncaria medicinal material samples according to the method of step (2), and select The spectral information under the characteristic band is imported into the established quantitative calibration model to obtain the content values ​​of moisture, extract, rhynchophylline and isorhynchophylline of the unknown Uncaria medicinal material sample. The invention realizes rapid and comprehensive detection of Uncaria medicinal materials by introducing near-infrared spectrum technology, and the method has the advantages of simple operation, high accuracy and high precision.

Description

technical field [0001] The invention belongs to the technical field of medical detection, and in particular relates to a method and application for rapidly detecting Uncaria medicinal materials by using near-infrared spectroscopy. Background technique [0002] Uncaria is Uncaria Uncaria (Miq.) Miq.exHavil., Uncariarhynchophylla Wall., UncariahirsutaHavil., Uncariasinensis (Oliv.) Havil or UncariassilifructusRoxb. Dry hooked stems. The active ingredients of Uncaria are mainly rhynchophylline and isorynchophylline, which have high medicinal value. The 2010 edition of "Chinese Pharmacopoeia" records that Uncaria has the functions of relieving wind and calming convulsions, clearing heat and calming the liver. It moves within the liver wind, convulsions, febrile convulsions, cold convulsions, infantile cries, pregnancy eclampsia, headache and dizziness, etc. Both have good efficacy. In recent years, scholars at home and abroad have conducted a lot of research on the pharmacolo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/3563G01N21/359G01N30/88
Inventor 谭沛马鹏岗栾连军陈红英刘志刚孙芬芳陈佳乐金叶李琼娅马舒冰
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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