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A drug for intractable epilepsy

An intractable, drug technology, applied in the field of drugs and preparations for the treatment of intractable epilepsy, can solve the problems of drug dissolution affecting tablet disintegration, slow action, content reduction, etc., to achieve satisfactory clinical efficacy, improve symptoms, and relieve pain. Effect

Active Publication Date: 2018-10-12
AFFILIATED RENHE HOSPITAL OF CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the defective that exists in the existing preparation method is, the disintegration of tablet or the stripping of medicine will be affected when auxiliary material selection or preparation condition is controlled improperly, the content of the tablet containing volatile medicine may decline after long-term storage; Injection cures quickly, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A preparation method of a medicine for treating intractable epilepsy, comprising the steps of:

[0018] (1) Pretreatment of valerian extract:

[0019] Remove fibrous roots and reed heads from 20g of valerian herbal medicine until the water content is less than 2%, grind valerian root into a coarse powder with a diameter of less than 0.3mm with a pulverizer, and use 3-8% ethanol equal to the weight of valerian herb The coarse powder is soaked for 20-28 hours, and then refluxed with 60% ethanol, which accounts for 3 times the weight of the Valerian Chinese herbal medicine, to collect the extract, reduce the pressure, concentrate and recover the ethanol, and finally use 50% ethanol, which accounts for 1.5 times the weight of the Valerian Chinese medicinal material. The extract is refluxed again to extract the extracted extract, the ethanol is recovered, and the valerian extract is collected.

[0020] (2) Preparation of intractable epilepsy drugs:

[0021] Take 200.0g of ...

Embodiment 2

[0023] Drug Stability Experiment for the Treatment of Intractable Epilepsy Prepared by the Invention

[0024] (1) Determination of Nuxychnium powder:

[0025] Refer to the 2010 Chinese Pharmacopoeia Nuxychnium powder content determination method for detection, and at the same time verify the analysis method; verify the precision, linearity, repeatability, stability, etc. to ensure that the analysis is effective. The average content of strychnine was measured as: 0.017mg / tablet; the average content of strychnine was: 0.038mg / tablet. With reference to Pharmacopoeia and clinical medication notice: the consumption of Nuxychnium powder is 0.2-0.6g, and the content of Nuxychnium powder of the present invention is 2.5mg / sheet (strychnine is 0.017mg / sheet, strychnine is 0.038mg / sheet ), the dose is far lower than the Pharmacopoeia and clinical drug standards, and the safety is better.

[0026] (2) Determination of phenobarbital content:

[0027] Detect with reference to the 2010 Ch...

Embodiment 3

[0031] Acute Toxicity Test Study of the Medicine for Treating Intractable Epilepsy Prepared by the Invention

[0032] 1. Take 50 healthy mice with a body weight that meets the requirements, weighing 17-22g, 10 in each group, both male and female, provided by the Hubei Medical Experimental Animal Center. Divided into A, B, C, D, E5 groups. Test product The medicine (the specification is 0.4g / sheet) of the present invention is provided by the preparation room of Renhe Hospital, Three Gorges University, and the preparation approval number is No. DX07-011 of Eyao Zhizi (2001), and it is prepared with distilled water before use. 0.08g / L test suspension (stock solution). According to the pre-test results, take the suspension (stock solution) for testing and the diluents whose mass concentration is 0.068, 0.058, 0.049, 0.042g / L diluted with distilled water in equal proportion before use.

[0033] 2. The mice in each group were intragastrically administered at a dose of 0.4ml per 2...

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Abstract

The invention provides a medicine for treating refractory epilepsy. The medicine is a preparation prepared from the following raw materials in parts by weight: 45-62 parts of Phenobarbital, 125-153 parts of potassium bromide, 5.5-12.6 parts of valerian extract, 6.8-11.5 parts of camphor, 1.5-3.5 parts of fried nux vomica powder, 80-120 parts of calcium gluconate, 80-120 parts of calcium carbonate; and the medicinal auxiliary materials comprise a disintegrating agent and a lubricating agent, wherein the disintegrating agent accounts for 20-80 percent of the total mass of the raw materials, and the lubricating agent accounts for 2-10 percent of the total mass of the raw materials. The preparation method comprises the following steps: performing valerian extract pretreatment and preparing the medicine for treating the refractory epilepsy. The medicine produced by the invention can achieve the effects of obviously improving the anti-epileptic curative effect, shortening the course of treatment, rapidly improving the symptoms, relieving the pain and reducing the use amount of Western medicines, the adverse reactions are obviously lower than those of the Western medicines, and the satisfied clinical curative effect is achieved.

Description

technical field [0001] The invention relates to a medicine for treating intractable epilepsy and a preparation method thereof. Background technique [0002] Epilepsy is a chronic brain disease with various clinical and laboratory manifestations and recurrent seizures caused by excessive discharge of brain neurons. With the rapid development of modern medicine, although most epilepsy can be controlled or cured, 30% of intractable epilepsy cannot be effectively treated. The present invention develops Chinese and Western medicine compound antiepileptic preparations on the basis of folk prescriptions, utilizes the synergistic sedation and anticonvulsant effects of phenobarbital and valerian; Reflexively inhibit the excitability of the cerebral cortex nerves or interfere with the conduction of abnormal excitatory impulses of neurons, so as to achieve the anti-epileptic effect of the combination of Chinese and Western medicine. But the defective that exists in the existing prepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/56A61P25/08A61K33/10A61K31/125A61K31/191A61K31/515A61K33/00
CPCA61K9/2059A61K31/125A61K31/191A61K31/515A61K33/00A61K33/10A61K36/185A61K36/56A61K36/84A61K2236/15A61K2236/17A61K2236/333A61K2236/39A61K2300/00
Inventor 廖勇游艳李志英朱春华周琴白荣陈俊谭艳菊陈红梅何芬芳申西华代金枝
Owner AFFILIATED RENHE HOSPITAL OF CHINA THREE GORGES UNIV
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