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Pharmaceutical composition containing imidafenacin

A midanacin and composition technology, applied in the field of midanacin pharmaceutical compositions and their preparation, can solve the problems of low release, poor stability, poor particle fluidity and the like, and achieve good dissolution and stability Good, solve the effect of large-scale industrial production

Active Publication Date: 2015-01-14
KUNMING JIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The conventional preparation method in the prior art prepares the new preparation of midana. Due to the physical and chemical properties of the new material of midana, it is easy to cause the particles in the prepared tablet to have poor fluidity, stickiness, poor stability, low release rate, complicated process, and production. High cost, difficult to achieve industrialized mass production
[0010] In order to improve product quality and overcome the problem of incapable of industrialized production, we have carried out a lot of design and research on technical solutions, selected the optimal prescription and process, and solved the above technical defects

Method used

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  • Pharmaceutical composition containing imidafenacin
  • Pharmaceutical composition containing imidafenacin
  • Pharmaceutical composition containing imidafenacin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] (1) Prescription

[0074] Midanaxin 0.1g

[0075] Microcrystalline Cellulose 65g

[0076] 70g pregelatinized starch

[0077] Magnesium stearate 0.9g

[0078] Coating agent 4g

[0079] 50% ethanol aqueous solution appropriate amount

[0080] Makes 1000 pieces

[0081] (2) Preparation method

[0082] 1) Preparation and processing of raw and auxiliary materials: Pass Midanacin and other auxiliary materials through an 80-mesh sieve for later use;

[0083] 2) Weighing and mixing: Weigh the above raw and auxiliary materials according to the prescription amount and calculate the feeding amount after checking by two people;

[0084] 3) Mixing: Mix the prescribed amount of midanacin with the prescribed amount of pregelatinized starch first, and then mix it with the prescribed amount of microcrystalline cellulose to make it fully mixed;

[0085] 4) Granulation: Add 50% ethanol water solution to the uniformly mixed material to obtain a soft material with suitable hardness,...

Embodiment 2

[0094] (1) Prescription

[0095] Midanaxin 0.1g

[0096] Microcrystalline Cellulose 95g

[0097] 40g pregelatinized starch

[0098] Magnesium stearate 0.9g

[0099] Coating agent 4g

[0100] 50% ethanol aqueous solution appropriate amount

[0101] Makes 1000 pieces

[0102] (2) The preparation method is the same as in Example 1.

Embodiment 3

[0104] (1) Prescription

[0105] Midanaxin 0.1g

[0106] Microcrystalline Cellulose 81g

[0107] Pregelatinized starch 54g

[0108] Magnesium stearate 0.9g

[0109] Coating agent 4g

[0110] 50% ethanol aqueous solution appropriate amount

[0111] Makes 1000 pieces

[0112] (2) The preparation method is the same as in Example 1.

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Abstract

The invention relates to a pharmaceutical composition containing imidafenacin and a preparation method of the pharmaceutical composition. Imidafenacin is mixed with pregelatinized starch and microcrystalline cellulose according to a certain ratio. The composition obtained by the invention is simple in prescription, mature in preparation process and good in dissolution effect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a midanacin pharmaceutical composition and a preparation method thereof. Background technique [0002] Overactive bladder (OAB) is a common condition characterized by urinary urgency, with or without urge incontinence, often accompanied by frequency and nocturia. The symptoms of OAB are caused by the involuntary contraction of the detrusor muscle during bladder filling. The etiology is still not very clear. It may be caused by damage to the central inhibitory efferent pathway, the peripheral sensory afferent pathway or the bladder muscle itself. . [0003] The number of patients worldwide is about 50 million to 100 million. There are slightly more women than men in patients, and the incidence rate increases with age. At present, the drugs used in clinical treatment mainly include anticholinergic drugs, adrenoceptor agonists, neurosensory afferen...

Claims

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Application Information

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IPC IPC(8): A61K9/30A61K31/4174A61K47/38A61K47/36A61P13/10
Inventor 严洁李轩
Owner KUNMING JIDA PHARMA
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